<i>In Vitro</i> Study: Bioactivity, Biocompatibility and Antibacterial Behavior for Polyetheretherketone Composites

Abstract

Polyetheretherketone (PEEK) as alternate biomaterial to traditional metallic implant materials has become greater important. At the same time have greater chemical resistance, mechanical properties, biocompatibility and radiolucency, making it convenient for use as dental and orthopedic implants. In the present study the biological behavior was evaluated of polymer composites based polyetheretherketone combined with various nano hydroxyapatite and nano titanium dioxide blending up to (1.5 wt%). The bioactivity of the specimens was evaluated by investigation apatite formation after immersion for 7 days and 14 days in simulated body fluid (SBF). XRD and SEM were used to approve the bioactivity of the specimens. Cell viability, proliferation, and the cell attachment activity of L929 mouse fibroblast cells was evaluated after (1, 3 & 5) days by MTT assay. Antibacterial property of the specimens versus S. aureus was observed with optical density methods. The results detected that the apatite-like layer formation was clearly observed on specimens after immersion for different period in simulated body fluid (SBF). Moreover, Results of MTT assay recorded the PEEK specimens excited the activity of fibroblasts and therefore a high cytocompatibility was noticed and specimens showed antibacterial properties against S. aureus.