Anesthetic and clinical assessments of I/V propofol versus ketamine in Dogs premedicated with diazepam

Abstract

The present anesthetic investigation was aimed to evaluate anesthetic clinico-physiological and hematobiochemical effects in addition to the anesthetic properties of propofol or ketamine premedicated with diazepam . For this purpose, 12 apparently healthy dogs were randomly divided into Two groups: A and B. All dogs were premedicated with Diazepam (0.2mg/kg Bwt/IM) then intravenous anesthesia was induced in group A with propofol intravenous (1mg/kg Bwt) ,while group B with ketamine intravenous (5 mg/kg Bwt). Blood samples were collected from the Two groups 15 minutes before anesthesia induction, then at (15, 30, 45 and 60) minutes after treatments for the hemato-biochemical evaluation, and for clinico-physiological observations. A slight alteration in some physiological parameters and hemato-biochemical values was observed after anesthesia induction, but it still safe to induce general anesthesia in dogs. in conclusion, the present anesthetic investigation showed the longest period of anesthesia with complete muscle relaxation following intravenous ketamine injection than propofol in premedicated dogs with diazepam.