{"title":"Altered Circadian Rhythm of genes involved in Human Senescence: An Interactome Analysis","authors":"Adrija Aich, Ashish Kumar, Kavitha Thirumurugan","doi":"10.25303/1810rjbt2160226","DOIUrl":null,"url":null,"abstract":"Genes related to human senescence were explored to find their interaction with Circadian rhythm using Cytoscape. Upregulated genes were analyzed for functional enrichment. In Cytohubba, top 10 ranking genes were scored for attributes like MCC, degree etc. TP53 was identified as a top-ranking gene in these attributes. The cancer network was retrieved in Network analyzer of Cytohubba and merged with TP53 network. The merged network was queried for ‘cisplatin’ using STICH in Cytoscape. Enrichment analysis of cisplatin bound TP53 network showed GO process cellular response to abiotic stimulus, negative regulation of telomere capping, replicative senescence, regulation of reactive oxygen species and cellular senescence.","PeriodicalId":21091,"journal":{"name":"Research Journal of Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research Journal of Biotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25303/1810rjbt2160226","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
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Abstract
Genes related to human senescence were explored to find their interaction with Circadian rhythm using Cytoscape. Upregulated genes were analyzed for functional enrichment. In Cytohubba, top 10 ranking genes were scored for attributes like MCC, degree etc. TP53 was identified as a top-ranking gene in these attributes. The cancer network was retrieved in Network analyzer of Cytohubba and merged with TP53 network. The merged network was queried for ‘cisplatin’ using STICH in Cytoscape. Enrichment analysis of cisplatin bound TP53 network showed GO process cellular response to abiotic stimulus, negative regulation of telomere capping, replicative senescence, regulation of reactive oxygen species and cellular senescence.
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