"A Linkage Between Oncoprotein Erbb2 Expression and Tumor-Associated Pro-Coagulant Properties of Breast Cancer Cells is Mediated by the Pi3k/Akt Signaling Pathways"

Abstract

Venous thromboembolism (VTE) and cancer are strongly associated, as the local or systemic activation of blood coagulation can be produced by tumor products and favours tumor spread. The occurrence of thrombosis is often the first indicator of an underlying malignancy and patient data also demonstrates a close association between tumour progression and the development of a procoagulant profile, supporting the hypothesis that the activation of the blood coagulation system contributes to tumour aggressiveness and vice versa [1].