{"title":"人の長寿と長生きの抗酸菌；抗酸菌がゆっくりと生きて頻繁に眠るしくみから、薬剤開発への展開を考える","authors":"Sohkichi Matsumoto","doi":"10.5025/hansen.92.41","DOIUrl":null,"url":null,"abstract":"Research that responds to the desire to live longer and be healthier has led to the discovery of life extention through calorie restriction. Interestingly, this mechanism is conserved from nematodes to mice to primates. Important molecular mechanisms for this longevity effect is the suppression of gene expression and metabolism, including respiration, through upregulation of sirtuin genes and suppression of mTOR signaling.","PeriodicalId":35918,"journal":{"name":"Japanese Journal of Leprosy","volume":"15 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese Journal of Leprosy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5025/hansen.92.41","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
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Abstract
Research that responds to the desire to live longer and be healthier has led to the discovery of life extention through calorie restriction. Interestingly, this mechanism is conserved from nematodes to mice to primates. Important molecular mechanisms for this longevity effect is the suppression of gene expression and metabolism, including respiration, through upregulation of sirtuin genes and suppression of mTOR signaling.
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