{"title":"Synthetic Element Chemistry based on Precise Designs of Reagents and Transition States","authors":"Keiichi Hirano, Masanobu Uchiyama","doi":"10.5059/yukigoseikyokaishi.81.1096","DOIUrl":null,"url":null,"abstract":"In recent years, the use of various elements has been attracting large attention in drug discovery and materials science. Particularly, organoborons and organosilicons are promising candidates owing to their high stability and relatively low toxicity. However, there are still limitations in the available chemical structures and hence development of novel skeletal-constructing methods is an urgent task in synthetic chemistry. Based on precise designs of boron and silicon ate complexes through an integration of theoretical and experimental chemistry, we have developed novel boration and silylation reactions.","PeriodicalId":17123,"journal":{"name":"Journal of Synthetic Organic Chemistry Japan","volume":"121 6","pages":"0"},"PeriodicalIF":0.2000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Synthetic Organic Chemistry Japan","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5059/yukigoseikyokaishi.81.1096","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
In recent years, the use of various elements has been attracting large attention in drug discovery and materials science. Particularly, organoborons and organosilicons are promising candidates owing to their high stability and relatively low toxicity. However, there are still limitations in the available chemical structures and hence development of novel skeletal-constructing methods is an urgent task in synthetic chemistry. Based on precise designs of boron and silicon ate complexes through an integration of theoretical and experimental chemistry, we have developed novel boration and silylation reactions.