REACTIVE BLOOD CHANGES IN THE PRACTICE OF PEDIATRIC PHYSICIAN, ONCOLOGIST AND HEMATOLOGIST: BIBLIOGRAPHICAL REVIEW AND CLINICAL CASE

Q4 Medicine Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-06-01 DOI:10.24110/0031-403x-2023-102-3-189-196

A.S. Klyut, T.T. Valiev, T.S. Belysheva, O.A. Malikhova, T.V. Nasedkina, O.A. Gusarova, K.I. Kirgizov, S.R. Varfolomeeva

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Abstract

Reactive blood changes are a heterogeneous group of pathological conditions that can occur in response to various conditions: viral, bacterial infections, helminth toxins, allergic agents. These reactions often require differential diagnosis with malignant neoplasms (MN) of the blood and hematopoietic organs (leukemias, lymphomas). It is important to note that only with a comprehensive examination of the patient with the involvement of a pediatric oncologist and hematologist, it is possible to exclude MN and carry out etiotropic treatment that contributes to the normalization of hemogram parameters. Article represents current data on the etiopathogenesis of leukemoid reactions, reactive thrombocytosis, secondary erythrocytosis and a clinical case observation of the development of a pseudoblast leukemoid reaction and reactive thrombocytosis against the background of an infectious process in a patient with Peutz-Jeghers syndrome, which will be of use to a wide range of pediatric practitioners.

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儿科医师、肿瘤学家和血液学家实践中的反应性血液变化:文献回顾和临床病例

反应性血液变化是一组异质的病理条件，可发生在各种条件的反应:病毒，细菌感染，寄生虫毒素，过敏剂。这些反应通常需要与血液和造血器官的恶性肿瘤(MN)(白血病、淋巴瘤)鉴别诊断。值得注意的是，只有在儿科肿瘤学家和血液学家的参与下对患者进行全面检查，才有可能排除MN并进行有助于血液图参数正常化的致病因治疗。这篇文章代表了目前的数据关于白血病样反应，反应性血小板增多，继发性红细胞增多的发病机制和假细胞白血病样反应和反应性血小板增多的临床病例观察在Peutz-Jeghers综合征患者感染过程的背景下，这将是广泛的儿科从业人员使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatriya - Zhurnal im G.N. Speranskogo Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.60

自引率

0.00%

发文量

150

期刊介绍： Journal “Pediatria” named after G.N. Speransky (the official short names of the Journal are “Journal «Pediatria»,” “Pediatria,” and “«Pediatria,» the Journal”) is the oldest Soviet-and-Russian (in the Russian Federation, the CIS and former Soviet Union) scientific and practical medical periodical assigned for pediatricians that is published continuously since May, 1922, and distributed worldwide. Our mission statement specifies that we aim to the ‘raising the level of skills and education of pediatricians, organizers of children’s health protection services, medicine scientists, lecturers and students of medical institutes for higher education, universities and colleges worldwide with an emphasis on Russian-speaking audience and specific, topical problems of children’s healthcare in Russia, the CIS, Baltic States and former Soviet Union Countries and their determination with the use of the World’s best practices in pediatrics.’ As part of this objective, the Editorial of the Journal «Pediatria» named after G.N. Speransky itself adopts a neutral position on issues treated within the Journal. The Journal serves to further academic discussions of topics, irrespective of their nature - whether religious, racial-, gender-based, environmental, ethical, political or other potentially or topically contentious subjects. The Journal is registered with the ISSN, - the international identifier for serials and other continuing resources, in the electronic and print world: ISSN 0031-403X (Print), and ISSN 1990-2182 (Online). The Journal was founded by the Academician, Dr. Georgiy Nestorovich SPERANSKY, in May, 1922. Now (since 1973) the Journal bears his honorary name.