IMPACT OF AGE AND GENDER ON SPIROMETRIC PARAMETERS IN ADOLESCENTS WITH BRONCHIAL ASTHMA

Q4 Medicine Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-10-13 DOI:10.24110/0031-403x-2023-102-5-8-13

K.V. Gorbunova, R.N. Khramova, T.I. Eliseeva, D.Yu. Ovsyannikov, S.V. Krasilnikova, E.V. Tush, N.I. Kubysheva, O.V. Khaletskaya

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Abstract

Peculiarities of the course of bronchial asthma (BA) in adolescents from the standpoint of the influence of age and gender on it cannot be considered fully studied as yet. Materials and methods used: the data were obtained from 367 patients’ records of atopic BA aged 10 to 17 years old (73,6% boys) who were treated for atopic BA at the Nizhny Novgorod City Children’s Clinical Hospital No. 1 (Nizhny Novgorod, Russia). The patients were divided into two age groups: early adolescence (EA, 10 to 14 y/o, 239 patients) and middle adolescence (MA, 15 to 17 y/o, 128). All patients underwent spirometric studies with an assessment of the forced vital capacity of the lungs (FVC), the ratio of forced expiratory volume in one second (FEV1) to FVC (FEV1/FVC), the average volume velocity of forced exhalation, averaged in the exhalation interval from 25 to 75% FVC (FEF25-75). Spirometric parameters were evaluated using the z-criteria of the Global Lung Initiative. Results: in the general group of patients, the zFVC index was statistically significantly lower in MA compared to EA (p=0,001), and the indicators of zFEV1/FVC and zFEF25-75 were statistically significantly higher in MA (p=0,020, p=0,022 respectively). In the cohort of boys, there were similar differences in spirometric parameters in EA and MA (p=0,009, p=0,002, p=0,002, respectively). In girls, the values of FVC in MA were statistically significantly lower than in EA (p=0,0310, as in the general cohort and the cohort of boys). At the same time, in girls, the indicators of zFEV1/FVC and zFEF25-75, reflecting bronchial permeability, were slightly lower in MA than in EA, but the differences were not statistically significant. Conclusion: in boys, but not in girls, the spirometric parameters reflecting bronchial patency in MA were statistically significantly higher than in EA. At the same time, in both boys and girls, the indicators of FVC decrease in MA compared to EA, remaining above the population median values of indicators.

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年龄和性别对青少年支气管哮喘患者肺量测定参数的影响

从年龄和性别对青少年支气管哮喘病程的影响来看，其病程的特殊性尚未得到充分的研究。使用的材料和方法:数据来自下诺夫哥罗德市第一儿童临床医院(Nizhny Novgorod, Russia) 367例10 - 17岁特应性BA患者的记录(73,6%为男孩)。患者分为青春期早期(EA, 10 ~ 14岁，239例)和青春期中期(MA, 15 ~ 17岁，128例)两个年龄组。所有患者都进行了肺活量测定，评估肺用力肺活量(FVC)、一秒钟用力呼气量(FEV1)与FVC的比率(FEV1/FVC)、用力呼气的平均体积速度，呼气间隔从25%到75% FVC (FEF25-75)。使用全球肺倡议的z标准评估肺活量测定参数。结果:普通组MA患者zFVC指数明显低于EA患者(p= 0.001)， MA患者zFEV1/FVC、zFEF25-75指标明显高于EA患者(p= 0.020、p= 0.022)。在男孩队列中，EA和MA的肺活量测定参数也存在类似差异(p=0,009, p=0,002, p=0,002)。在女孩中，MA组的FVC值显著低于EA组(p=0,0310，与普通组和男孩组相同)。同时，在女孩中，反映支气管通透性的zFEV1/FVC和zFEF25-75指标在MA组略低于EA组，但差异无统计学意义。结论:MA组男生反映支气管通畅的肺活量指标高于EA组，女生无统计学差异。同时，MA组男生和女生FVC指标均低于EA组，均高于人群中位数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatriya - Zhurnal im G.N. Speranskogo Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.60

自引率

0.00%

发文量

150

期刊介绍： Journal “Pediatria” named after G.N. Speransky (the official short names of the Journal are “Journal «Pediatria»,” “Pediatria,” and “«Pediatria,» the Journal”) is the oldest Soviet-and-Russian (in the Russian Federation, the CIS and former Soviet Union) scientific and practical medical periodical assigned for pediatricians that is published continuously since May, 1922, and distributed worldwide. Our mission statement specifies that we aim to the ‘raising the level of skills and education of pediatricians, organizers of children’s health protection services, medicine scientists, lecturers and students of medical institutes for higher education, universities and colleges worldwide with an emphasis on Russian-speaking audience and specific, topical problems of children’s healthcare in Russia, the CIS, Baltic States and former Soviet Union Countries and their determination with the use of the World’s best practices in pediatrics.’ As part of this objective, the Editorial of the Journal «Pediatria» named after G.N. Speransky itself adopts a neutral position on issues treated within the Journal. The Journal serves to further academic discussions of topics, irrespective of their nature - whether religious, racial-, gender-based, environmental, ethical, political or other potentially or topically contentious subjects. The Journal is registered with the ISSN, - the international identifier for serials and other continuing resources, in the electronic and print world: ISSN 0031-403X (Print), and ISSN 1990-2182 (Online). The Journal was founded by the Academician, Dr. Georgiy Nestorovich SPERANSKY, in May, 1922. Now (since 1973) the Journal bears his honorary name.