Effects of Cannabidiol in Adolescent and Young Adult Depressive and Anxiety Disorders: A Systematic Review of Clinical and Preclinical Research

IF 0.4 Q4 PEDIATRICS Adolescent Psychiatry Pub Date : 2023-10-04 DOI:10.2174/0122106766233339230919143924
Rebecca K. Denson, Julia Brooks, Graziano Pinna, Natania A . Crane
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Abstract

Background: Adolescents and young adults may use cannabidiol (CBD) products in an attempt to reduce depression and anxiety symptoms, despite little research examining this use. This systematic review evaluated preclinical and clinical research on the effects of CBD on depressive and anxiety disorders in adolescence and young adulthood. To provide context, we discuss CBD’s mechanism of action and neurodevelopmental effects. Methods: PubMed was searched for articles published through June 2022. Preclinical or clinical CBD administration studies with N > 1 that examined depressive and/or anxiety disorders were eligible. Results: Initially, 224 publications were identified. After excluding duplicates and applying eligibility criteria, 6 preclinical (depression: n≈133; anxiety: n≈161) and 4 clinical (anxiety: n=113) articles remained. Due to the low number of studies, results were synthesized qualitatively. The Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence were used to rate each study’s evidence. The preclinical effects of CBD on depression-like behavior appear to differ by sex, early life stress, and duration of use. Despite no evidence that CBD exerts anxiolytic effects in preclinical adolescent models, CBD may reduce anxiety symptoms in human adolescents and young adults with anxiety disorders. Conclusion: The existing evidence suggests that CBD may reduce symptoms of anxiety in adolescents and young adults. However, the evidence is sparse and limited by variations in samples and CBD dosing duration. Further research is needed to understand the potential benefits and/or harms of CBD for depression and anxiety disorders in this population. Implications for clinical practice and research are discussed.
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大麻二酚对青少年抑郁和焦虑症的影响:临床和临床前研究的系统回顾
背景:青少年和年轻人可能会使用大麻二酚(CBD)产品来减轻抑郁和焦虑症状,尽管很少有研究检查这种使用。本系统综述评估了CBD对青春期和青年期抑郁和焦虑障碍的临床前和临床研究。为了提供背景,我们讨论了CBD的作用机制和神经发育作用。方法:检索PubMed截至2022年6月发表的文章。N >临床前或临床CBD给药研究;1名检查抑郁症和/或焦虑症的患者符合条件。结果:最初,确定了224篇出版物。在排除重复并应用资格标准后,6例临床前抑郁症:n≈133;焦虑:n≈161)和4篇临床(焦虑:n=113)文章。由于研究数量少,结果是定性合成的。牛津循证医学中心2011年证据水平被用于评估每项研究的证据。CBD对抑郁样行为的临床前影响似乎因性别、早期生活压力和使用时间而异。尽管没有证据表明CBD在临床前青少年模型中具有抗焦虑作用,但CBD可能会减轻患有焦虑症的青少年和年轻人的焦虑症状。结论:现有证据表明,CBD可能减轻青少年和年轻人的焦虑症状。然而,证据是稀疏的,并且受到样本和CBD剂量持续时间变化的限制。需要进一步的研究来了解CBD对这一人群的抑郁症和焦虑症的潜在益处和/或危害。对临床实践和研究的意义进行了讨论。
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来源期刊
Adolescent Psychiatry
Adolescent Psychiatry PEDIATRICS-
CiteScore
0.80
自引率
0.00%
发文量
20
期刊介绍: Adolescent Psychiatry a peer-reviewed journal, aims to provide mental health professionals who work with adolescents with current information relevant to the diagnosis and treatment of psychiatric disorders in adolescents. Adolescent Psychiatry reports of original research, critical reviews of topics relevant to practitioners, clinical observations with analysis and discussion, analysis of philosophical, ethical or social aspects of the fields of psychiatry and mental health, case reports with discussions, letters, and position papers. Topics include adolescent development and developmental psychopathology, psychotherapy and other psychosocial treatment approaches, psychopharmacology, and service settings and programs. The primary focus of the work should be on adolescents, transition-aged youth, The primary focus of the work should be on adolescents, transition-aged youth, or emerging adults, that is, persons 12-24 years of age . Articles on families of adolescents, or adults who have been followed since adolescence will also be considered.
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