Prognostic Relevance of Serum Ferritin on Short Term and Long term Outcome In Patients With Acute Myocardial Infarction

Abstract

Objective-Over the decades coronary artery disease appears to be an emerging cause of mortality andmorbidity. Elevated serum ferritin as a risk factor for development of AMI. However its role with regard tooutcome and prognosis of AMI still remains a matter of debate. Hence, the present study was aimed toestimate the prognostic relevance of serum ferritin in relation to short term and long term survival outcomes inpatients with AMI.Methods- Out of a total number of 100 patients,with first AMI (50 of STEMI & 50 of NSTEMI diagnosis)admitted within 12 hours of the onset of chest pain to coronary care units at MKCG MedicalCollege&Hospital over a period of 1 year. Serum ferritin was measured using an ELISA assay by a special kit.The patients were divided into three groups according to Serum ferritin level.i.e.(1sttertile:<120 ng/ml,2ndtertile:120 to 220 ng/ml and 3rd tertile:>220 ng/ml).Baselinecharacteristics,LVEjection Fraction, Killipfunctional class and outcomes were compared among three different groups of serum ferritin.Results:There was a significant correlation between serum ferritin and LV ejection fraction(p=0.01),Killipclass(p=0.03) and mortality(p=0.03). Lower and higher levels of ferritin (1st and 3rd tertiles, ≤ 120; >220 ng/ml,respectively) were associated with a higher incidence of HF during hospitalization and death at 1 year.Conclusion:Raised serum ferritin is associated with worse short term and longterm outcome followingmyocardial infarction.