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Relation of Hepatitis B Viral Load with Hepatitis B Envelope Antigen in Hepatitis B Positive Cases 乙型肝炎阳性患者乙型肝炎病毒载量与乙肝包膜抗原的关系
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19808
Background: Despite of effective vaccineand impressive treatment, number of cases of hepatitis b virus rising dayby day. The reasons include low antibody titre in blood after vaccination, needle stick injury in medical personnel,lack of awareness in general public about the mode of transmissions and prevention. Also the treatment part isexpensive and monitored by repeated viral load and envelope antigen estimation.We are conducted a study todecrease the cost of diagnosis and monitoring of treatment by analyse if anyrelationship between viral load andenvelope antigen.Method: Total number of 54 blood samples of hepatitis b positive patients who were known to be infected the timeof withdrawn of blood, collected in a period of one year.The serums separated by centrifugation and preserved.All samples were tested for viral load by Thermo Fisher PCR kit and also for estimation of hepatitis b envelopeantigen by indirect ELISA. Results were analysed.Conclusion: On the basis of this study we can conclude that there is a relationship between hepatitis b envelopeantigen and viral load. When viral load reached in a patient up to a particular level antigen start rising andthen both proportionally increasing. In our study that particular level of viral loadis >106 copies/ml. It shows ifenvelope antigen of hepatitis b virus present in blood, the value of viral load should be more than 106copies/ml.In the scarcity of PCR only Elisa for envelope antigen can draw an approximate estimation of viral load.
背景:尽管有有效的疫苗和令人印象深刻的治疗,乙型肝炎病毒的病例数量仍在日益增加。原因包括疫苗接种后血液抗体滴度低、医务人员被针刺伤、公众对传播方式和预防认识不足。此外,治疗部分是昂贵的,并通过重复病毒载量和包膜抗原估计监测。我们进行了一项研究,通过分析病毒载量和包膜抗原之间的关系来降低诊断和治疗监测的成本。方法:收集1年内已知感染的乙型肝炎阳性患者采血标本54份。血清经离心分离保存。所有样本均采用Thermo Fisher PCR试剂盒检测病毒载量,并采用间接ELISA法检测乙型肝炎包膜抗原。对结果进行分析。结论:乙型肝炎包膜抗原与病毒载量之间存在相关性。当患者体内的病毒载量达到特定水平时,抗原开始上升,然后两者成比例地增加。在我们的研究中,特定水平的病毒载量为106拷贝/毫升。提示血液中存在乙型肝炎病毒包膜抗原时,病毒载量应大于106拷贝/ml。在缺乏PCR的情况下,只有包膜抗原Elisa法可以大致估计病毒载量。
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引用次数: 0
Comparison of Lipid Profile of Sedentary Workers with the Athletes Undertaking Aerobic Exercises Regularly 久坐工人与定期进行有氧运动运动员的血脂比较
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19793
Background: Incidence of cardiovascular disease has increased rapidly in India. Serum lipid levels are among themost important causative factors which in turn related to lifestyle of an individual.Aim: This study was aimed to compare the lipid profile of sedentary workers with the athletes undertakingexercises regularly.Materials and Methods: It was a cross sectional analytical study. It was undertaken among 150 adult males ofage 20-50 years. Participants were selected on the basis history of regular exercise and apparently healthy adultmales with no athletic or exercise activity for comparison. Known sufferers of hypertension, dyslipidemia oron anti-hyperlipidemic drugs were excluded. All five athletic clubs in district town of Birbhum were selectedfor data collection. Estimation of serum lipids was done at the biochemistry laboratory of the district hospitals.Results: Mean total Cholesterol level (mg/dl) of the non-athletes (208.7 ± 30.7) was found to be more than athletes(197.3 ± 71.1) and the finding was statistically not significant (p = 0.21). Mean LDL level (mg/dl) non-athletes (131.5± 24.3) was found to be more than athletes (107.5 ± 15.5) and the finding was statistically significant (p=0.000).Conclusion: Regular physical activity improves the HDL cholesterol which is known cardio-protective. Thoughthe total cholesterol was lower in athletes compared to those with sedentary life style but the finding was notstatistically significant. This study did include the diet history of the participants.
背景:印度的心血管疾病发病率迅速上升。血脂水平是最重要的致病因素之一,而血脂水平又与个人的生活方式有关。目的:本研究旨在比较久坐不动的工人和定期运动的运动员的血脂水平。材料与方法:采用横断面分析研究。研究对象为150名年龄在20-50岁之间的成年男性。参与者是根据有规律运动的历史和没有运动或锻炼活动的明显健康的成年男性进行比较的。排除已知患有高血压、血脂异常或抗高脂血症药物的患者。选取birbham镇的所有五个体育俱乐部进行数据收集。血脂测定在区医院生化实验室进行。结果:非运动员的平均总胆固醇(mg/dl)(208.7±30.7)高于运动员(197.3±71.1),差异无统计学意义(p = 0.21)。非运动员平均LDL水平(mg/dl)(131.5±24.3)高于运动员(107.5±15.5),差异有统计学意义(p=0.000)。结论:有规律的体育锻炼可提高高密度脂蛋白胆固醇水平,对心脏有保护作用。虽然运动员的总胆固醇比那些久坐不动的人低,但这一发现在统计上并不显著。这项研究确实包括了参与者的饮食史。
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引用次数: 0
Study to Assess the Knowledge of Hospital Waste Management among Healthcare Personnel at Medical College in Haryana 哈里亚纳邦医学院医护人员医院废弃物管理知识评估研究
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19813
Background: Hospital Waste collection and proper disposal has become a significant concern for both the medicaland general community. It is estimated that 10-25% of healthcare waste is hazardous, with the potential to createa variety of health problems. Handling, segregation, mutilation, disinfection, storage, transportation and finaldisposal are vital steps for safe and scientific management of Hospital waste in any establishment.Objectives: To assess the knowledge of hospital Waste management among healthcare personnel working in atertiary care centre.Methods: To assess the knowledge of hospital Waste management among healthcare personnel working in atertiary care hospital. A hospital based cross sectional study was conducted. The Study participants includednursing staff, ward boys and cleaning staff working in the institute who deal with Medical waste and were selectedrandomly to make the sample size of 250 with equal representation in both categories. A pretested semi-structuredquestionnaire was used.Results: The study showed gaps in the knowledge of categories of respondents. The knowledge of the existence ofMedical waste management in nurses was (79%), as well as in cleaning staff was (37%). The knowledge in practicalaspects of Medical waste management was better in nurses, as compare to cleaning staff.
背景:医院废物的收集和妥善处理已成为医学界和一般社会关注的一个重要问题。据估计,10-25%的医疗废物是有害的,有可能造成各种健康问题。处理、分离、切割、消毒、储存、运输和最终处置是任何机构安全、科学地管理医院废物的重要步骤。目的:了解三级保健中心医护人员对医院废弃物管理知识的了解情况。方法:对三级医院医务人员的医院废弃物管理知识进行调查。以医院为基础进行了横断面研究。研究参与者包括在研究所处理医疗废物的护理人员、护工和清洁人员,他们被随机选择,样本量为250人,在这两个类别中具有相同的代表性。采用预测半结构化问卷。结果:调查显示受访者对类别的了解存在差距。护士(79%)和清洁人员(37%)了解医疗废物管理的存在。与清洁人员相比,护士在医疗废物管理实践方面的知识更丰富。
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引用次数: 0
A Prospective Comparative Observational Study on Maternal and Fetal Outcome in Oligohydramnios 羊水过少对母胎结局的前瞻性比较观察研究
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19777
Background: The health of the mother and foetus is threatened by oligohydramnios. It is a clinical conditionidentified by a sonographically measured amniotic fluid index (AFI) of less than 5 cm.Method & Materials: Hospital-based based prospective comparative Observational Study. This study wasconducted to observe the outcome of pregnancy in oligohydramnios. Study group– 100 cases with AFI < 5 cm.Control group- 100 cases with AFI 5cm to 24 cm, admitted to Dept. of Obstetrics and Gynaecology in TMCH from1stAugust 2021 to 31 July 2022. For all selected women, USG was done and AFI was calculated. These womenwere followed till day 7 of puerperium. Data were analyzed using IBM SPSS version 23. The variable was analyzedusing a chi-square test p-<0.05 was considered statistically significant.Results: The results of the present study revealed that, the rate of the Caesarian section was significantly higher inthe oligohydramnios group compared to the control group (70% vs. 39% respectively). There was a significantlyincreased in Fetal distress, meconium-stained liquor, low Apgar score at 1 and 5 min, low birth weight, admissionto NICU, and early neonatal death.Conclusion: In conclusion, oligohydramnios is a high-risk pregnancy, and patients with oligohydramnios shouldexpect proper antepartum, rigorous foetal surveillance, and intrapartum care for a better feto-maternal outcome
背景:羊水过少严重威胁母体和胎儿的健康。这是一种临床病症,超声测量羊水指数(AFI)小于5厘米。方法,资料:基于医院的前瞻性比较观察研究。本研究旨在观察羊水过少的妊娠结局。研究组- 100例AFI患者;5厘米。对照组:2021年8月1日至2022年7月31日在妇产科学医院妇产科收治的AFI 5 - 24 cm患者100例。对所有入选女性进行USG并计算AFI。这些妇女被跟踪到产褥期第7天。数据分析采用IBM SPSS version 23。采用卡方检验对变量进行分析,p-<0.05认为具有统计学意义。结果:本研究结果显示,羊水过少组剖宫产率明显高于对照组(分别为70%和39%)。胎儿窘迫、粪污液、1分钟和5分钟低Apgar评分、低出生体重、入住新生儿重症监护病房和新生儿早期死亡显著增加。结论:羊水过少是一种高危妊娠,羊水过少患者应做好适当的产前监护、严格的胎儿监护和产时护理,以获得较好的胎母结局
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引用次数: 0
A Link between Anxiety and Sattvik Food as a Potential Pathway 焦虑与萨特维克食物之间的联系是一种潜在的途径
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19791
One of the main causes that has put a person’s social and physical health under stress but also significantlyimpacted their mental health is epidemic. The most prevalent and well observed mental condition is anxiety. It cancause a paradigm shift in the eating habits of an individual. The 5000-year-old Indian medical system Ayurveda,which educates about hostile care for the mind, body, and spirit relates major psychological stress like anxiety withimproper diet. Following a sattvik diet helps a person lead a stress-free life and reduces a person’s risk of illnessto mental disorders like depression, anxiety, mood disorders, and hyperacidity; Sattvik diet/ aahar is consideredas one of the safe, organic and energetic food. People who eat a diet high in whole food such as fruits, nuts, wholegrains, legumes and unsaturated fats are up to 35% less likely to develop depression than those who eat less ofthese. A healthy digestion of meal with proper engagement of gastric juices, its digestion and absorption aredirectly related to hormonal balance and production of serotonin level.
使一个人的社会和身体健康处于压力之下,同时也严重影响他们的心理健康的主要原因之一是流行病。最普遍和最容易观察到的精神状况是焦虑。它会导致个人饮食习惯的范式转变。有着5000年历史的印度医学体系阿育吠陀(Ayurveda)将焦虑等主要心理压力与不适当的饮食联系在一起,教导人们对身心和精神的敌意治疗。遵循满意的饮食可以帮助一个人过上无压力的生活,降低一个人患抑郁症、焦虑症、情绪障碍和胃酸过多等精神疾病的风险;萨特维克饮食被认为是安全、有机和充满活力的食品之一。饮食中富含水果、坚果、全谷物、豆类和不饱和脂肪的人患抑郁症的可能性比少吃这些食物的人低35%。膳食的健康消化和胃液的适当参与,其消化和吸收与激素平衡和血清素水平的产生直接相关。
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引用次数: 0
Addressing the Socio-demographic Determinants of COVID-19 Vaccine Hesitancy among the General Population in a Rural Block of Andhra Pradesh, India: A Community Based Cross-sectional Study 解决印度安得拉邦农村地区普通人群中COVID-19疫苗犹豫的社会人口决定因素:一项基于社区的横断面研究
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19783
Background: Vaccine hesitancy continues to impede the attempts made globally in combating the COVID-19pandemic. Hence, this study aims to determine the socio-demographic factors associated with COVID-19 vaccinehesitancy among the general population in a rural block of Andhra Pradesh.Methods: A community based cross-sectional study was conducted among the general population of a rural blockin Andhra Pradesh. A total of 210 participants were recruited through multi- stage random sampling technique.Data was collected through semi-structured schedule method. Descriptive statistics was computed to describethe socio-demographic characteristics, and Chi-square test was applied to assess the association between vaccinehesitancy and socio-demographic characteristics of the study participants.Results: COVID-19 vaccine hesitancy rate among rural population was 45.5%. Statistically significant associationwas observed between vaccine hesitancy and socio-demographic characteristics like: age between 40-49 years,females, Hindus, illiterates, unemployed, marginal workers, lower middle class and those with two children intheir family.Conclusion: High prevalence of vaccine hesitancy was noted among rural population. Mass media strategies,evidence-based communication, and policy measures will have to be implemented across rural areas with specialfocus on groups identified with vaccine hesitancy.
背景:对疫苗的犹豫继续阻碍着全球抗击covid -19大流行的努力。因此,本研究旨在确定安得拉邦农村地区普通人群中与COVID-19疫苗犹豫相关的社会人口因素。方法:在安得拉邦农村地区的一般人群中进行了基于社区的横断面研究。采用多阶段随机抽样方法,共招募了210名参与者。数据采集采用半结构化调度方法。描述性统计用于描述社会人口学特征,卡方检验用于评估疫苗犹豫与研究参与者社会人口学特征之间的关系。结果:农村人群新冠肺炎疫苗犹豫率为45.5%。在统计上观察到疫苗犹豫与社会人口统计学特征之间的显著关联,如年龄在40-49岁之间,女性,印度教徒,文盲,失业,边缘工人,中下层阶级和家庭中有两个孩子的人。结论:农村人群疫苗犹豫率较高。必须在农村地区实施大众媒体战略、以证据为基础的沟通和政策措施,特别关注被确定为疫苗犹豫的群体。
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引用次数: 0
Diabetes Mellitus and its Association with Body Mass Index in Sputum Positive Tuberculosis Patients in a Tertiary Health Care Centre 某三级卫生保健中心痰阳性肺结核病人的糖尿病及其与体重指数的关系
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19832
Background: Tuberculosis is a chronic infectious disease that causes pulmonary tuberculosis and also affectsother tissues of the body. People with diabetes mellitus and those who are underweight have an increased risk ofgetting active tuberculosis. The objectives of the study were to estimate the prevalence of diabetes mellitus and todetermine its association with Body Mass Index in tuberculosis patients.Methods: In the present record-based cross-sectional study, 100 sputum smear positive tuberculosis patients 18years and older who attended the out-patient department of Pulmonary Medicine from 1/6/2020 to 31/12/2022were included and sputum smear negative patients were excluded. Data entry and analysis was done in MicrosoftExcel. Percentages were calculated and association between diabetes mellitus and Body Mass Index of the studypopulation was assessed by chi square test.Conclusion: The prevalence of diabetes mellitus in tuberculosis patients was almost double than that of thegeneral population of India and its association with underweight was found to be statistically significant. Soproper screening of all patients of tuberculosis for diabetes mellitus is necessary for early diagnosis and treatment.Health education and counselling are equally important
背景:结核病是一种慢性传染病,可引起肺结核,也可影响身体其他组织。糖尿病患者和体重过轻的人患活动性肺结核的风险增加。本研究的目的是估计肺结核患者中糖尿病的患病率,并确定其与体重指数的关系。方法:采用基于记录的横断研究方法,纳入2020年6月1日至2022年12月31日在肺内科门诊就诊的18岁及以上痰涂片阳性结核病患者100例,排除痰涂片阴性患者。数据录入和分析在MicrosoftExcel中完成。计算百分比,并通过卡方检验评估糖尿病与研究人群体重指数之间的相关性。结论:印度结核病患者中糖尿病的患病率几乎是普通人群的两倍,其与体重不足的关系具有统计学意义。因此,对所有结核病患者进行适当的糖尿病筛查对于早期诊断和治疗是必要的。健康教育和咨询同样重要
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引用次数: 0
Legal Solutions to Health Misinformation and Disinformation During the Covid-19 Pandemic Outbreak Covid-19大流行期间卫生错误信息和虚假信息的法律解决方案
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19787
The spread of false information online has increased dramatically in recent years. Around the COVID-19 pandemic,a digital epidemic of misinformation, or “infodemic,” has arisen. Since the beginning of 2020, digital platformshave served as both a source of and a remedy for Disinformation. After a few months of the epidemic, it is clearthat ensuring health professionals access to necessary medical equipment and supplies is less crucial than fightingfalsehoods online. Actions such as (a) urging social media firms to delete material about the epidemic that iscontentious, (b) putting up special forces to counteract propaganda and false information (e.g., E.U., U.K.), and (c)incarcerating suspicious coronavirus false claims, including in connection to the public health interventions, werehigh priorities for many government agencies around the world in response to COVID-19. State of emergencymeasures used early on shaped future debates on how to strike a fair balance between free speech and censorshipon the internet by, among other things, restricting access to news and encouraging journalists to hold back on theirreporting.
近年来,网上虚假信息的传播急剧增加。在2019冠状病毒病大流行期间,出现了一种错误信息的数字流行病,或称“信息流行病”。自2020年初以来,数字平台既是虚假信息的来源,也是虚假信息的补救措施。经过几个月的疫情,很明显,确保卫生专业人员获得必要的医疗设备和用品比打击网上的虚假信息更重要。采取以下行动:(a)敦促社交媒体公司删除有关该流行病的有争议的材料,(b)组建特种部队来抵制宣传和虚假信息(例如,欧盟、英国),以及(c)监禁可疑的冠状病毒虚假声明,包括与公共卫生干预措施有关的声明,这些行动是世界各地许多政府机构在应对COVID-19时的优先事项。早期使用的紧急状态措施影响了未来关于如何在言论自由和互联网审查之间取得公平平衡的辩论,其中包括限制获取新闻和鼓励记者克制他们的报道。
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引用次数: 0
Clinico-epidemiological Profile of Paraquat Poisoning in Children at a Tertiary Care Centre: Case Series 三级保健中心儿童百草枯中毒的临床流行病学概况:病例系列
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19755
Aims and objectives: This case series is done to know the Clinico-epidemiological profile of paraquat poisoningin children and also the implication of available treatment guidelines in improving outcomes in the paediatricpopulation as there are no standard treatment guidelines available.Materials and Methods: Nine children were selected during the study period of October 2021 to February 2023,demographic data were collected, clinical parameters were assessed with details such as time of presentation,symptoms and first aid received, laboratory parameters such as LFT, RFT, chest radiographs obtained and serialvalues monitored. Treatment as per the available recommendation was initiated with immunosuppressive therapyand haemodialysis on a case-to-case basis.Results: Among the 9 children, there were 6 females (67%) with an average age group of 15–18 years. eight (89%)of the 9 children developed acute renal failure. Seven children underwent haemodialysis. Five (55%) childrendeveloped hepatic dysfunction. Among the 9 children, 3 (67%) survived.Conclusion: The study reveals that the mortality rate can be reduced, if the child presented to the hospital within8 hours of ingestion of the compound, amount ingested is less than 20 ml, and early initiation of Haemodialysiswithin 8 hours and a trail of immunosuppressive therapy.
目的和目的:本病例系列是为了了解儿童百草枯中毒的临床-流行病学概况,以及由于没有标准治疗指南,现有治疗指南对改善儿科人群预后的影响。材料与方法:在2021年10月至2023年2月的研究期间,选取9名儿童,收集人口统计学资料,评估临床参数,如出现时间、症状和接受的急救,LFT、RFT等实验室参数,获得胸片并监测序列值。根据现有的治疗建议,免疫抑制治疗和血液透析是在个案的基础上开始的。结果:9例患儿中,女性6例(67%),平均年龄15 ~ 18岁。9例患儿中有8例(89%)发生急性肾功能衰竭。7名儿童接受了血液透析。5名(55%)儿童出现肝功能障碍。9例患儿中3例(67%)存活。结论:本研究表明,如果患儿在摄入该化合物8小时内就诊,摄入量小于20ml, 8小时内早期开始血液透析,并进行免疫抑制治疗,可降低死亡率。
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引用次数: 0
Cross-sectional Study on Pattern of Ear, Nose and Throat Disorders among School Children in a Rural Area of West Bengal 西孟加拉邦农村地区学龄儿童耳鼻喉疾患模式的横断面研究
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19829
Background: Ear, Nose and Throat diseases are common in school going children who often miss school dueto these illnesses. ENT diseases have not been given due importance by majority of the school authorities. Theimportance of ENT diseases screening is to identify the children at-risk, which may hamper their scholasticperformance, and to refer them for detailed investigation and intervention.Objectives: 1. To find out the pattern of common Ear, Nose and Throat Disorders among School children. 2. Tofind out the association if any regarding ENT morbidities and socio-demographic variables of the parents.Materials and Methods: The study was a descriptive observational type of cross-sectional design. The school waschosen by random sampling method. Data were collected by interviewing the school children with a pre-designedand pretested schedule. Clinical examinations were done with the help of a check list containing the standardanswer and definition of ENT morbidities. Collected data were analysed and proportions and Chi-square testwere done.Results: Among study population 52.6% were female and most of the children (63.5%) were < 14 years of agegroup. 61.6% having some form of ENT morbidities. Literacy status of parents and economic condition of thefamily were significantly associated with ENT morbidities.Conclusion: Urgent need for health education and regular Ear, Nose and Throat check-up among the schoolchildren to increase their level of awareness and knowledge regarding ENT diseases and also decrease morbidities
背景:耳鼻喉疾病在上学的孩子中很常见,他们经常因为这些疾病而缺课。大多数学校当局没有给予耳鼻喉科疾病应有的重视。耳鼻喉科疾病筛查的重要性在于识别可能影响其学习成绩的高危儿童,并将其转介进行详细的调查和干预。目的:1。了解学龄儿童常见的耳鼻喉疾患模式。2. 找出耳鼻喉科发病率与父母的社会人口变量之间的关系。材料与方法:本研究为描述性观察型横断面设计。采用随机抽样的方法选择学校。数据是通过预先设计和预先测试的时间表采访学生来收集的。临床检查是在包含耳鼻喉科发病率标准答案和定义的检查表的帮助下完成的。对收集的资料进行分析,并进行比例和卡方检验。结果:在研究人群中,女性占52.6%,大多数儿童(63.5%)是<14岁年龄组。61.6%患有某种形式的耳鼻喉科疾病。父母文化水平和家庭经济状况与耳鼻喉科发病率显著相关。结论:迫切需要对小学生进行健康教育,定期进行耳鼻喉检查,以提高他们对耳鼻喉科疾病的认识和知识水平,降低发病率
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引用次数: 0
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Indian Journal of Public Health Research and Development
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