Radiographic Evaluation of the Effect of Vitamin D3 Supplementation on Regeneration of Calvarial Bone Defects in Rats

IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Clinical and Experimental Health Sciences Pub Date : 2023-09-26 DOI:10.33808/clinexphealthsci.1262852

Gülce Nil VARLIHAN, Ömer Birkan AĞRALI, Hatice Selin YILDIRIM, Sibel DEMİRCİ DELİPINAR, Leyla KURU, Hafize ÖZTÜRK ÖZENER

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Abstract

Aim: The present study was aimed to evaluate radiographically the effect of orally administered vitamin D3 on guided bone regeneration in calvarial critical size defects (CSD) in rats. Methods: Two calvarial CSD were created in 12 male Sprague-Dawley rats. One of the defects was left empty (E defect), while the other one was treated with deproteinized bovine bone graft and collagen-based resorbable membrane (GM-filled defect). Following surgical intervention, rats were randomly assigned into two groups; the control group was administered distilled water, and the test group was treated with 2 µg /kg vitamin D3 by gavage once a day for 8 weeks. Radiological images were obtained from rats on 4th and 8th weeks. The area fraction of newly formed osteoid was determined using Image Fiji Analysis Software. Results: The percentages of area fraction in the GM-filled defects were statistically higher than the E defects in both study groups at 4th and 8th weeks (p

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补充维生素D3对大鼠颅骨骨缺损再生影响的影像学评价

目的:本研究旨在评价口服维生素D3对大鼠颅骨临界大小缺损(CSD)引导骨再生的影响。方法:选取12只雄性sd大鼠，建立2只颅骨CSD。其中1个缺损留空(E缺损)，另1个缺损采用脱蛋白牛骨移植物和胶原基可吸收膜(gm -填充缺损)处理。手术干预后，将大鼠随机分为两组;对照组给予蒸馏水，试验组给予维生素D3 2µg /kg灌胃，每天1次，连续8周。在第4周和第8周获得大鼠的放射图像。使用Image Fiji分析软件测定新形成的骨样物的面积分数。& # x0D;结果:在第4周和第8周，两组gm填充缺损的面积分数百分比均高于E缺损(p

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Clinical and Experimental Health Sciences MEDICINE, RESEARCH & EXPERIMENTAL-

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