Pub Date : 2023-10-04DOI: 10.33808/clinexphealthsci.1347081
Ömer AYDINER, Hüseyin Kemal RAŞA
Objective: The best option for treating high-risk patients with acute cholecystitis is still being determined. We evaluated our high-risk acute cholecystitis patients in whom we preferred percutaneous cholecystostomy and aimed to determine whether this approach was safe and feasible.
Methods: We retrospectively reviewed our 71 patients in whom we performed percutaneous cholecystostomy between May 2019 and July 2023. All procedures were performed with local anaesthesia under ultrasonographic guidance via the transhepatic route. The catheters were removed when the signs of acute cholecystitis were significantly regressed or when the catheters were found to be ineffective. The catheters of those eligible for surgery were removed during the operations.
Results: All procedures were successful without failure, and no significant complications developed in the post-intervention period. Pain at the catheter insertion site (20 patients) was the leading minor complication, and in one patient, bilioma was detected and percutaneously drained. The procedure was ineffective in 7 patients (9.85%), and the catheters were removed. In 22 patients (31%), interval cholecystectomy surgery was performed. In the subgroup of patients whose catheters were adequate and were not operated (5 patients), the catheters were removed after an average of 27.2 days. The mean length of stay was 9.6 days, and four patients died (5.6%) during the index hospitalization.
Conclusion: Our findings suggest that percutaneous cholecystostomy is a feasible, safe and highly effective treatment option for acute cholecystitis in high-risk patients.
{"title":"Percutaneous Cholecystostomy is a Feasible and Safe Option for High-Risk Acute Cholecystitis Patients","authors":"Ömer AYDINER, Hüseyin Kemal RAŞA","doi":"10.33808/clinexphealthsci.1347081","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1347081","url":null,"abstract":"Objective: The best option for treating high-risk patients with acute cholecystitis is still being determined. We evaluated our high-risk acute cholecystitis patients in whom we preferred percutaneous cholecystostomy and aimed to determine whether this approach was safe and feasible. 
 Methods: We retrospectively reviewed our 71 patients in whom we performed percutaneous cholecystostomy between May 2019 and July 2023. All procedures were performed with local anaesthesia under ultrasonographic guidance via the transhepatic route. The catheters were removed when the signs of acute cholecystitis were significantly regressed or when the catheters were found to be ineffective. The catheters of those eligible for surgery were removed during the operations. 
 Results: All procedures were successful without failure, and no significant complications developed in the post-intervention period. Pain at the catheter insertion site (20 patients) was the leading minor complication, and in one patient, bilioma was detected and percutaneously drained. The procedure was ineffective in 7 patients (9.85%), and the catheters were removed. In 22 patients (31%), interval cholecystectomy surgery was performed. In the subgroup of patients whose catheters were adequate and were not operated (5 patients), the catheters were removed after an average of 27.2 days. The mean length of stay was 9.6 days, and four patients died (5.6%) during the index hospitalization. 
 Conclusion: Our findings suggest that percutaneous cholecystostomy is a feasible, safe and highly effective treatment option for acute cholecystitis in high-risk patients.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135647362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-26DOI: 10.33808/clinexphealthsci.1345763
Alev BAKIR KAYI, Benan MÜSELLİM
Objective: Mortality studies are interpreted by considering comorbid diseases related to the main disease. Existence, number, and type of comorbid diseases can have an important effect on prognosis. There are various comorbidity indices to include the effects of comorbid diseases in the model. With a new perspective, we aimed to emphasize the importance of evaluating the combination of comorbid diseases in cancer survival.
Methods: Retrospective cohort, data were collected from cases with Non-Small Cell Lung Cancer treated in Department of Chest Diseases. Initially, the effects of their comorbid diseases on the duration of survival were calculated with univariate analysis, then examined according to number of comorbidities, lastly their specific combinations' Hazar Ratio were calculated with Cox multivariate analysis. The most used comorbid indices in the literature were also included.
Results: Out of 247 non-small cell lung cancer (NSCLC) cases analysis, 220 (89%) were men. Median duration of follow-up was 277 days, at the end of the follow-up 197 cases had died. HR of two comorbid diseases in cases was 1.80, but 59.52 for the combination of “diabetes and interstitial lung disease” and 3.76 for “diabetes and previously cancer”. Existing comorbid indices had no significant effect on survival time (p:0.684; 0.101; 0.273; 0.567, respectively).
Conclusion: We have offered a new perspective which takes into comorbid diseases related to main disease and specially their combinations when the risk is estimated in survival research. Accurate assessments of the list of comorbid diseases related to main disease hold significant importance in advancing this field.
{"title":"A New Perspective on the Evaluation of Comorbidity Indices on Survival in Non-Small Cell Lung Cancer","authors":"Alev BAKIR KAYI, Benan MÜSELLİM","doi":"10.33808/clinexphealthsci.1345763","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1345763","url":null,"abstract":"Objective: Mortality studies are interpreted by considering comorbid diseases related to the main disease. Existence, number, and type of comorbid diseases can have an important effect on prognosis. There are various comorbidity indices to include the effects of comorbid diseases in the model. With a new perspective, we aimed to emphasize the importance of evaluating the combination of comorbid diseases in cancer survival.
 Methods: Retrospective cohort, data were collected from cases with Non-Small Cell Lung Cancer treated in Department of Chest Diseases. Initially, the effects of their comorbid diseases on the duration of survival were calculated with univariate analysis, then examined according to number of comorbidities, lastly their specific combinations' Hazar Ratio were calculated with Cox multivariate analysis. The most used comorbid indices in the literature were also included.
 Results: Out of 247 non-small cell lung cancer (NSCLC) cases analysis, 220 (89%) were men. Median duration of follow-up was 277 days, at the end of the follow-up 197 cases had died. HR of two comorbid diseases in cases was 1.80, but 59.52 for the combination of “diabetes and interstitial lung disease” and 3.76 for “diabetes and previously cancer”. Existing comorbid indices had no significant effect on survival time (p:0.684; 0.101; 0.273; 0.567, respectively).
 Conclusion: We have offered a new perspective which takes into comorbid diseases related to main disease and specially their combinations when the risk is estimated in survival research. Accurate assessments of the list of comorbid diseases related to main disease hold significant importance in advancing this field.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":"138 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135721389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The present study was aimed to evaluate radiographically the effect of orally administered vitamin D3 on guided bone regeneration in calvarial critical size defects (CSD) in rats.
Methods: Two calvarial CSD were created in 12 male Sprague-Dawley rats. One of the defects was left empty (E defect), while the other one was treated with deproteinized bovine bone graft and collagen-based resorbable membrane (GM-filled defect). Following surgical intervention, rats were randomly assigned into two groups; the control group was administered distilled water, and the test group was treated with 2 µg /kg vitamin D3 by gavage once a day for 8 weeks. Radiological images were obtained from rats on 4th and 8th weeks. The area fraction of newly formed osteoid was determined using Image Fiji Analysis Software.
Results: The percentages of area fraction in the GM-filled defects were statistically higher than the E defects in both study groups at 4th and 8th weeks (p
{"title":"Radiographic Evaluation of the Effect of Vitamin D3 Supplementation on Regeneration of Calvarial Bone Defects in Rats","authors":"Gülce Nil VARLIHAN, Ömer Birkan AĞRALI, Hatice Selin YILDIRIM, Sibel DEMİRCİ DELİPINAR, Leyla KURU, Hafize ÖZTÜRK ÖZENER","doi":"10.33808/clinexphealthsci.1262852","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1262852","url":null,"abstract":"Aim: The present study was aimed to evaluate radiographically the effect of orally administered vitamin D3 on guided bone regeneration in calvarial critical size defects (CSD) in rats.
 Methods: Two calvarial CSD were created in 12 male Sprague-Dawley rats. One of the defects was left empty (E defect), while the other one was treated with deproteinized bovine bone graft and collagen-based resorbable membrane (GM-filled defect). Following surgical intervention, rats were randomly assigned into two groups; the control group was administered distilled water, and the test group was treated with 2 µg /kg vitamin D3 by gavage once a day for 8 weeks. Radiological images were obtained from rats on 4th and 8th weeks. The area fraction of newly formed osteoid was determined using Image Fiji Analysis Software. 
 Results: The percentages of area fraction in the GM-filled defects were statistically higher than the E defects in both study groups at 4th and 8th weeks (p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135721401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-18DOI: 10.33808/clinexphealthsci.1195447
Y. Kasımoğlu, S. C. İlisulu, C. Baysan, M. Koruyucu, F. Seymen
Objective: The COVID-19 pandemic has deeply affected the entire world. This study aims to evaluate Turkish dentists’ awareness of and protective measures against COVID-19 infection. Methods: A web-based questionnaire consisting of 35 closed-ended and multiple-choice questions was prepared according to Turkish Dental Association guidelines. The questionnaire was divided into three domains: demographic data, precautionary measures, and attitude. Ethical clearance was obtained from the Istanbul University institutional review board. questionnaire was sent to the dentists registered with the Turkish Dental Association. The minimum sample size was calculated as 756 individuals. The Chi-Square test was used to evaluate the difference for categorical variables. Statistical significance was accepted as p< .05. Results: A total of nine hundred and ninety-seven questionnaires was analyzed. Five hundred and sixty-three respondents (56.5%) were general dentists, and 434 (43.5%) were specialists. Seven hundred and thirty-five (73.7%) dentists were found to wear disposable gowns, N95/FFP2 masks, and face shields. About half (48.1%) were confident of avoiding infection. Twenty-one (2.1%) subjects were SARS-Cov-2 positive. A majority of both dentists who had COVID-19 (71.4%) and dentists who did not have it (92.7%) agreed that COVID-19 is an occupational risk (p< .001). Conclusion: Although nearly two-thirds of the respondents reported using personal protective equipment, greater precautionary measures should be taken by dental staff to protect the patients from COVID-19 and other contagious diseases.
{"title":"Awareness of the Protective Measures Against Covid-19 among Turkish Dentists: A Questionnaire Survey","authors":"Y. Kasımoğlu, S. C. İlisulu, C. Baysan, M. Koruyucu, F. Seymen","doi":"10.33808/clinexphealthsci.1195447","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1195447","url":null,"abstract":"Objective: The COVID-19 pandemic has deeply affected the entire world. This study aims to evaluate Turkish dentists’ awareness of and protective measures against COVID-19 infection. Methods: A web-based questionnaire consisting of 35 closed-ended and multiple-choice questions was prepared according to Turkish Dental Association guidelines. The questionnaire was divided into three domains: demographic data, precautionary measures, and attitude. Ethical clearance was obtained from the Istanbul University institutional review board. questionnaire was sent to the dentists registered with the Turkish Dental Association. The minimum sample size was calculated as 756 individuals. The Chi-Square test was used to evaluate the difference for categorical variables. Statistical significance was accepted as p< .05. Results: A total of nine hundred and ninety-seven questionnaires was analyzed. Five hundred and sixty-three respondents (56.5%) were general dentists, and 434 (43.5%) were specialists. Seven hundred and thirty-five (73.7%) dentists were found to wear disposable gowns, N95/FFP2 masks, and face shields. About half (48.1%) were confident of avoiding infection. Twenty-one (2.1%) subjects were SARS-Cov-2 positive. A majority of both dentists who had COVID-19 (71.4%) and dentists who did not have it (92.7%) agreed that COVID-19 is an occupational risk (p< .001). Conclusion: Although nearly two-thirds of the respondents reported using personal protective equipment, greater precautionary measures should be taken by dental staff to protect the patients from COVID-19 and other contagious diseases.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":"19 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139339223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-14DOI: 10.33808/clinexphealthsci.1130449
Büşra DİNCER, Fatma ATALAY, Arzu TATAR
Objective: Ototoxicity is cellular damage caused by the use of solid treatments as chemotherapeutics in critical illnesses like cancer. The generation of free radicals is linked to fluctuating hearing loss caused by chemotherapeutics. Antioxidants can help to prevent ototoxicity-related oxidative damage. Carvone (CVN) is a monoterpene with excellent antioxidant properties that protect against oxidative damage. This study investigates the biochemical and functional aspects of CVN’s putative otoprotective mechanisms against paclitaxel (PCX)-induced ototoxicity.
Methods: 24 Wistar albino rats were assigned into four different groups: Control, CVN, PCX, and PCX+CVN. Once a week, the control group received saline. The PCX group received 5 mg/kg PCX intraperitoneally once a week (4 times). Once a week, the CVN group received 50 mg/kg intraperitoneally. The PCX+ CVN group received 5 mg/kg PCX followed by 5 mg/kg CVN once a week. All animals were subjected to deterioration product otoacoustic emission testing before (day 0) and after drug administration (day 23).
Results: PCX showed an ototoxic effect by weakening otoacoustic emission values. PCX leads to significant otoacoustic emission value shifts ameliorated by CVN co-treatment (for 2000Hz p< .001, for 4000 levels p< .01, for 6000Hz p< .001, and for 8000 Hz p< .01 in PCX+CVN group). Furthermore, the PCX group had significantly greater malondialdehyde levels and significantly lower glutathione levels in the cochlear tissues, compared to the other groups. Co-administered CVN with PCX reversed these effects, making oxidative stress parameters close to those of the control group (for GSH levels p< .001, for MDA levels p< .01 in the PCX+CVN group).
Conclusion: According to the findings, CVN appears to preserve cochlear function in rats against the disruptive effects of PCX.
{"title":"Otoprotective Mechanisms of Carvone As An Antioxidant Agent Against Ototoxic Damage Caused By Paclitaxel","authors":"Büşra DİNCER, Fatma ATALAY, Arzu TATAR","doi":"10.33808/clinexphealthsci.1130449","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1130449","url":null,"abstract":"Objective: Ototoxicity is cellular damage caused by the use of solid treatments as chemotherapeutics in critical illnesses like cancer. The generation of free radicals is linked to fluctuating hearing loss caused by chemotherapeutics. Antioxidants can help to prevent ototoxicity-related oxidative damage. Carvone (CVN) is a monoterpene with excellent antioxidant properties that protect against oxidative damage. This study investigates the biochemical and functional aspects of CVN’s putative otoprotective mechanisms against paclitaxel (PCX)-induced ototoxicity.
 Methods: 24 Wistar albino rats were assigned into four different groups: Control, CVN, PCX, and PCX+CVN. Once a week, the control group received saline. The PCX group received 5 mg/kg PCX intraperitoneally once a week (4 times). Once a week, the CVN group received 50 mg/kg intraperitoneally. The PCX+ CVN group received 5 mg/kg PCX followed by 5 mg/kg CVN once a week. All animals were subjected to deterioration product otoacoustic emission testing before (day 0) and after drug administration (day 23).
 Results: PCX showed an ototoxic effect by weakening otoacoustic emission values. PCX leads to significant otoacoustic emission value shifts ameliorated by CVN co-treatment (for 2000Hz p< .001, for 4000 levels p< .01, for 6000Hz p< .001, and for 8000 Hz p< .01 in PCX+CVN group). Furthermore, the PCX group had significantly greater malondialdehyde levels and significantly lower glutathione levels in the cochlear tissues, compared to the other groups. Co-administered CVN with PCX reversed these effects, making oxidative stress parameters close to those of the control group (for GSH levels p< .001, for MDA levels p< .01 in the PCX+CVN group).
 Conclusion: According to the findings, CVN appears to preserve cochlear function in rats against the disruptive effects of PCX.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134912212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The objective of this study was to investigate clinical effect of topically administered hyaluronic acid (HA) mouthwash on healing of secondary palatal wound in diabetic (D) rats.
Methods: 60 Wistar albino male rats were divided into D and non-diabetic (ND) groups. Diabetes was induced to 30 randomly selected rats by initially administering 110 mg/kg of nicotinamide intraperitoneally, followed by 15 min of intraperitoneal injection of 65 mg/kg of streptozotocin solution. 5 mm excisional wounds were made in the centre of the palate. After that, 6 animals from each group were sacrificed. Then, both groups were subdivided into two groups: 0.12% HA mouthwash and saline (S) (n=12 per group), depending on the agent to be administered to the wound area (WA). On days 7 and 14, six rats from each group were sacrificed, and the WAs were measured through photographic measurements utilizing Image J software.
Results: The WA decreased with time in each group (p
{"title":"Evaluation of the Clinical Effect of Hyaluronic Acid Mouthwash on Palatal Secondary Wound Healing in Diabetic Rats","authors":"Ezgi AKÇE, Sibel DEMİRCİ DELİPINAR, Leyla KURU, Hatice Selin YILDIRIM","doi":"10.33808/clinexphealthsci.1258371","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1258371","url":null,"abstract":"Objective: The objective of this study was to investigate clinical effect of topically administered hyaluronic acid (HA) mouthwash on healing of secondary palatal wound in diabetic (D) rats. 
 Methods: 60 Wistar albino male rats were divided into D and non-diabetic (ND) groups. Diabetes was induced to 30 randomly selected rats by initially administering 110 mg/kg of nicotinamide intraperitoneally, followed by 15 min of intraperitoneal injection of 65 mg/kg of streptozotocin solution. 5 mm excisional wounds were made in the centre of the palate. After that, 6 animals from each group were sacrificed. Then, both groups were subdivided into two groups: 0.12% HA mouthwash and saline (S) (n=12 per group), depending on the agent to be administered to the wound area (WA). On days 7 and 14, six rats from each group were sacrificed, and the WAs were measured through photographic measurements utilizing Image J software.
 Results: The WA decreased with time in each group (p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135887198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.33808/clinexphealthsci.1033882
Tülin BAYRAK, Gülsen ŞENER, Emel SAĞLAM GÖKMEN, Ahmet BAYRAK
Objective: Abnormal immune inflammatory response and cytokine storm play an important role on the aspect of increasing mortality in Covid-19. We aimed to investigate whether the Platelet Activating Factor Acetylhydrolase activity (PAF-AH) and hematological parameters have prognostic and predictive value in determining the disease severity.
Methods: A total of 84 Covid-19 patients, 52 of whom were hospitalized in the ward and 32 in the intensive care unit (ICU), and 38 control patients were included in this study.
Results: Lymphocyte and serum albumin levels were significantly lower (p < .001) and age, neutrophils, CRP, procalcitonin, LDH, INR, D-dimer levels were significantly higher (p < .001) in Covid-19 patients compared to the control group. ICU patients had significantly lower (p < .001) lymphocyte, albumin values and significantly higher (p < .001) age, leukocyte, neutrophils, CRP, INR, aPTT, D-dimer levels compared to ward patients. PAF-AH activity was significantly increased in ICU patients compared to the control group (p < .05). A positive correlation was found between PAF-AH and D-Dimer in the ICU group.
Conclusion: We found increased PAF-AH activity in patients with Covid-19. It’s important to spot the PAF-AH activity in cardiovascular events that develop due to coagulation problems, which are likely to be seen on these patients in the future.
{"title":"Platelet Activating Factor Acetylhydrolase (PAF-AH) activity : could it have a role on coagulation in covid-19 patients?","authors":"Tülin BAYRAK, Gülsen ŞENER, Emel SAĞLAM GÖKMEN, Ahmet BAYRAK","doi":"10.33808/clinexphealthsci.1033882","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1033882","url":null,"abstract":"Objective: Abnormal immune inflammatory response and cytokine storm play an important role on the aspect of increasing mortality in Covid-19. We aimed to investigate whether the Platelet Activating Factor Acetylhydrolase activity (PAF-AH) and hematological parameters have prognostic and predictive value in determining the disease severity.
 Methods: A total of 84 Covid-19 patients, 52 of whom were hospitalized in the ward and 32 in the intensive care unit (ICU), and 38 control patients were included in this study. 
 Results: Lymphocyte and serum albumin levels were significantly lower (p < .001) and age, neutrophils, CRP, procalcitonin, LDH, INR, D-dimer levels were significantly higher (p < .001) in Covid-19 patients compared to the control group. ICU patients had significantly lower (p < .001) lymphocyte, albumin values and significantly higher (p < .001) age, leukocyte, neutrophils, CRP, INR, aPTT, D-dimer levels compared to ward patients. PAF-AH activity was significantly increased in ICU patients compared to the control group (p < .05). A positive correlation was found between PAF-AH and D-Dimer in the ICU group.
 Conclusion: We found increased PAF-AH activity in patients with Covid-19. It’s important to spot the PAF-AH activity in cardiovascular events that develop due to coagulation problems, which are likely to be seen on these patients in the future.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135937969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.33808/clinexphealthsci.888309
Kezban KORAŞ SÖZEN, Neziha KARABULUT
Objective: The present study was conducted to determine of the relationship between family and social support and anxiety-depression levels in liver transplant patients.
Methods: The Introductory Characteristics Determination Form, Hospital Anxiety and Depression Scale (HADS), Multidimensional Perceived Social Support Scale (MPSSS) and Perceived Family Support Scale (PFSS) were used to question the socio-demographic characteristics of the patients.
Results: When the distribution of the mean anxiety and depression scores according to their introductory characteristics of the patients was examined, it was determined that the mean score of HADS was found to be high (HAD-A=19.71±3.29, HAD-D=15.90±1.99). The mean MPSSS of the patients was found to be at moderate level as 54.56±17.40; and the mean total score of the PFSS of the patients was found to be at high level as 35.77± 7.16. It was determined that family and social support was effective in reducing the depression levels after liver transplantation.
Conclusions: It was found that family and social support was influential in reducing the depression levels after liver transplantation.
{"title":"Determination of the Relationship Between Family and Social Support and Anxiety-Depression Levels in Liver Transplant Patients","authors":"Kezban KORAŞ SÖZEN, Neziha KARABULUT","doi":"10.33808/clinexphealthsci.888309","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.888309","url":null,"abstract":"Objective: The present study was conducted to determine of the relationship between family and social support and anxiety-depression levels in liver transplant patients.
 Methods: The Introductory Characteristics Determination Form, Hospital Anxiety and Depression Scale (HADS), Multidimensional Perceived Social Support Scale (MPSSS) and Perceived Family Support Scale (PFSS) were used to question the socio-demographic characteristics of the patients.
 Results: When the distribution of the mean anxiety and depression scores according to their introductory characteristics of the patients was examined, it was determined that the mean score of HADS was found to be high (HAD-A=19.71±3.29, HAD-D=15.90±1.99). The mean MPSSS of the patients was found to be at moderate level as 54.56±17.40; and the mean total score of the PFSS of the patients was found to be at high level as 35.77± 7.16. It was determined that family and social support was effective in reducing the depression levels after liver transplantation.
 Conclusions: It was found that family and social support was influential in reducing the depression levels after liver transplantation.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135937967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-05DOI: 10.33808/clinexphealthsci.1216743
Gülay Çakir, Zeliha ŞANIVAR ABBASGHOLIZADEH, Yılmaz Umut Aslan
Objective: To evaluate the shear bond strength (SBS) of yttrium-stabilized tetragonal zirconia polycrystals bonded to titanium alloys via different surface treatment methods using four different cements. Methods: Eighty titanium and monolithic zirconia discs were prepared with computer-aided design/manufacturing (CAD/CAM) technology. All titanium discs and 40 of monolithic zirconia discs were polished by using silicon carbide paper and sandblasted with 50 μm aluminum oxide (Al2O3). Tribochemical silica coating was applied to remaining 40 monolithic zirconia discs. The monolithic zirconia discs were divided into eight groups after surface treatment (n=10). Titanium discs were cemented using conventional glass ionomer cement (GIC), resin-modified GIC, self- adhesive resin cement, and dual-cure resin cement. The SBS test was performed using a universal testing machine. The failure patterns were examined by using a scanning electron microscope (SEM). Data were statistically analyzed with one-way analysis of variance (ANOVA), two-way ANOVA and Tukey’s test (α
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Objective: There are increasing studies examining retinal fiber layer (RNFL) and ganglion cell layer (GCL) thinning in patients with schizophrenia. However, the results are controversial, and clinical and cognitive reflections of these findings remain unclear. With this study, we aim to examine retinal abnormalities and establish correlations with cognitive and clinical parameters.
Methods: In this cross-sectional study, we examined 29 patients with schizophrenia and 13 age and gender-matched healthy controls. All participants underwent psychometric assessment, neuropsychological tests, and optical coherence tomography (OCT) measurements. The retinal fiber layer and ganglion cell layer thickness were used as retinal parameters.
Results: Five patients dropped out during the OCT measurement process, 24 patients with schizophrenia and nine healthy controls were included in the analysis. There was no statistically significant difference between groups in measuring retinal nerve fiber layer or ganglion cell layer thicknesses. The verbal fluency test score negatively correlated with left RNFL superior ( ρ – .422, p
目的:对精神分裂症患者视网膜纤维层(RNFL)和神经节细胞层(GCL)变薄的研究越来越多。然而，结果是有争议的，这些发现的临床和认知反映仍然不清楚。在这项研究中，我们的目的是检查视网膜异常，并建立与认知和临床参数的相关性。
方法:在这项横断面研究中，我们检查了29例精神分裂症患者和13例年龄和性别匹配的健康对照。所有参与者都进行了心理测量评估、神经心理测试和光学相干断层扫描(OCT)测量。以视网膜纤维层和神经节细胞层厚度作为视网膜参数。
结果:5例患者在OCT测量过程中退出，24例精神分裂症患者和9例健康对照纳入分析。各组间测量视网膜神经纤维层及神经节细胞层厚度差异无统计学意义。语言流畅性测试分数与左侧RNFL优势呈负相关(ρ - 0.422, p
{"title":"Neuropsychological and Clinical Correlations of Optical Coherence Tomography Findings in Patients with Schizophrenia","authors":"Ayşe SAKALLI KANİ, Cansun ŞAHİN ÇAM, Esra BİBEROĞLU ÇELİK, Uzay DURAL, Melike DURAN DÖNMEZ, Semra AKKAYA TURHAN, Ebru TOKER, Mesut YILDIZ","doi":"10.33808/clinexphealthsci.1331234","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1331234","url":null,"abstract":"Objective: There are increasing studies examining retinal fiber layer (RNFL) and ganglion cell layer (GCL) thinning in patients with schizophrenia. However, the results are controversial, and clinical and cognitive reflections of these findings remain unclear. With this study, we aim to examine retinal abnormalities and establish correlations with cognitive and clinical parameters.
 Methods: In this cross-sectional study, we examined 29 patients with schizophrenia and 13 age and gender-matched healthy controls. All participants underwent psychometric assessment, neuropsychological tests, and optical coherence tomography (OCT) measurements. The retinal fiber layer and ganglion cell layer thickness were used as retinal parameters.
 Results: Five patients dropped out during the OCT measurement process, 24 patients with schizophrenia and nine healthy controls were included in the analysis. There was no statistically significant difference between groups in measuring retinal nerve fiber layer or ganglion cell layer thicknesses. The verbal fluency test score negatively correlated with left RNFL superior ( ρ – .422, p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135307678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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