CLINICAL AND DIAGNOSTIC VALUE OF ANTINUCLEAR ANTIBODIES IN A PEDIATRIC PHYSICIAN’S PRACTICE (PART 3)

Q4 Medicine Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-10-13 DOI:10.24110/0031-403x-2023-102-5-123-134

N.S. Podchernyaeva, M.N. Nikolaeva, A.M. Bayramkulov

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Abstract

Antinuclear antibodies (ANA), first discovered many decades ago in patients with systemic lupus erythematosus (SLE), still remain a diagnostic criterion for this disease. However, subsequent studies have shown that the range of diseases in which ANA are detected is extremely wide and includes not only systemic rheumatic diseases, but also other autoimmune diseases (AD), including autoimmune cytopenias, autoimmune liver diseases, gastrointestinal diseases, autoimmune pathology of the thyroid gland and other endocrine glands, autoimmune skin diseases etc. The low specificity of ANA determines their relatively low diagnostic value, which increases when taking into account the luminescence pattern, indicating the presence of certain autoABs. The presence of ANA in patients with AD has a certain prognostic significance since in a number of diseases it is associated with their clinical features and the nature of the process as well as the expected response to the treatment with various drugs. Due to the fact that various AD are often combined in patients, the detection of ANA may be a reason for expanding the examination aiming to diagnose them in a timely manner. See Part 2 at N.S. Podchernyaeva, M.K. Osminina, E.V. Frolkova, M.A. Kudryashova, M.R. Gripp, N.Yu. Golovanov. Clinical and diagnostic value of antinuclear antibodies in a pediatric physician’s practice (Part 2). Pediatria n.a. G.N. Speransky. 2023; 102 (2): 78-89. DOI: 10.24110/0031-403X-2023-102-2-78-89, and Part 1 at N.S. Podchernyaeva, L.G. Khachatryan, M.K. Osminina, E.V. Frolkova, M.A. Kudryashova. Clinical diagnostic value of antinuclear antibodies in pediatric practice (part I). Pediatria n.a. G.N. Speransky. 2022; 101 (3): 185-198. - DOI: 10.24110/0031-403X-2022-101-3-185-198.

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抗核抗体在儿科临床诊断中的价值(三)

几十年前首次在系统性红斑狼疮(SLE)患者中发现的抗核抗体(ANA)至今仍是该病的诊断标准。然而，随后的研究表明，ANA可检测的疾病范围非常广泛，不仅包括全身性风湿性疾病，还包括其他自身免疫性疾病(AD)，包括自身免疫性细胞减少症、自身免疫性肝病、胃肠道疾病、甲状腺及其他内分泌腺体的自身免疫性病理、自身免疫性皮肤病等。ANA的低特异性决定了其相对较低的诊断价值，当考虑到发光模式时，诊断价值增加，表明存在某些自身抗体。在AD患者中存在ANA具有一定的预后意义，因为在许多疾病中，ANA与它们的临床特征、过程的性质以及对各种药物治疗的预期反应有关。由于各种AD在患者中经常合并，因此ANA的检测可能是扩大检查范围以及时诊断的一个原因。参见N.S. Podchernyaeva, M.K. Osminina, E.V. Frolkova, M.A. Kudryashova, M.R. Gripp, N.Yu的第二部分。Golovanov。抗核抗体在儿科医生实践中的临床和诊断价值(第二部分).儿科n.a G.N. Speransky. 2023;102(2): 78-89。DOI: 10.24110/0031-403X-2023-102-2-78-89，以及N.S. Podchernyaeva, L.G. Khachatryan, M.K. Osminina, E.V. Frolkova, M.A. Kudryashova的第一部分。抗核抗体在儿科临床中的诊断价值(上).中华儿科杂志。G.N. Speransky。2022;[j](3): 185-198。- doi: 10.24110/0031-403x-2022-101-3-185-198。

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来源期刊

Pediatriya - Zhurnal im G.N. Speranskogo Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.60

自引率

0.00%

发文量

150

期刊介绍： Journal “Pediatria” named after G.N. Speransky (the official short names of the Journal are “Journal «Pediatria»,” “Pediatria,” and “«Pediatria,» the Journal”) is the oldest Soviet-and-Russian (in the Russian Federation, the CIS and former Soviet Union) scientific and practical medical periodical assigned for pediatricians that is published continuously since May, 1922, and distributed worldwide. Our mission statement specifies that we aim to the ‘raising the level of skills and education of pediatricians, organizers of children’s health protection services, medicine scientists, lecturers and students of medical institutes for higher education, universities and colleges worldwide with an emphasis on Russian-speaking audience and specific, topical problems of children’s healthcare in Russia, the CIS, Baltic States and former Soviet Union Countries and their determination with the use of the World’s best practices in pediatrics.’ As part of this objective, the Editorial of the Journal «Pediatria» named after G.N. Speransky itself adopts a neutral position on issues treated within the Journal. The Journal serves to further academic discussions of topics, irrespective of their nature - whether religious, racial-, gender-based, environmental, ethical, political or other potentially or topically contentious subjects. The Journal is registered with the ISSN, - the international identifier for serials and other continuing resources, in the electronic and print world: ISSN 0031-403X (Print), and ISSN 1990-2182 (Online). The Journal was founded by the Academician, Dr. Georgiy Nestorovich SPERANSKY, in May, 1922. Now (since 1973) the Journal bears his honorary name.