Maria Vassilaki, Jeremy A. Syrjanen, Janina Krell-Roesch, Jonathan Graff-Radford, Prashanthi Vemuri, Eugene L. Scharf, Mary M. Machulda, Julie A. Fields, Walter K. Kremers, Val J. Lowe, Clifford R. Jack, David S. Knopman, Ronald C. Petersen, Yonas E. Geda
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引用次数: 0
Abstract
The study included 1,738 Mayo Clinic Study of Aging participants (≥50 years old; 1,460 cognitively unimpaired and 278 with mild cognitive impairment (MCI)) and examined the cross-sectional association between cerebrovascular (CVD) imaging biomarkers (e.g., white matter hyperintensities (WMH), infarctions) and Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI) scores, as well as their association with MCI. High (abnormal) WMH burden was significantly associated with having BDI-II>13 and BAI > 7 scores, and both (CVD imaging biomarkers and depression/anxiety) were significantly associated with MCI when included simultaneously in the model, suggesting that both were independently associated with the odds of MCI.
该研究纳入了1738名梅奥诊所老年研究参与者(≥50岁;1460名认知功能未受损和278名轻度认知障碍(MCI))，并检查了脑血管(CVD)成像生物标志物(如白质高信号(WMH)、梗死)与贝克抑郁量表- ii (BDI-II)和贝克焦虑量表(BAI)评分之间的横断面关联，以及它们与MCI的关系。高(异常)WMH负担与bdi - 1和BAI显著相关。当同时纳入模型时，两者(CVD成像生物标志物和抑郁/焦虑)都与MCI显著相关，这表明两者都与MCI的几率独立相关。
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