Design and evaluation of herbal tablet formulation (HTF) of leaves of Carica papaya linn, Moringa oleifera linn and fruit of Carrissa carandus lam

Abstract

The objective of the research paper to design and development of herbal tablet formulation (HTF) of leaves of Carica Papaya Linn (LCPL) & Moringao leiferaLinn (LMOL) and fruit part of Carrissa CarandusLam (FCCL).Powdered leaves of Carica Papaya Linn & Moringao leifera Linn and fruit part of Carrissa Carandus Lam was macerated in 80% hydro-ethanolic solution for 72 hours .To identify the active constituents, phyto-chemical screening was performed. The extracts were evaluated for the flavonoid and phenolic content by qualitative and quantitative measurement. The Leaves of LCPL& LMOL and fruit of FCCL was extracted by maceration process. Preliminary phytochemical screening was performed. The LCPL showed the presence of flavonoids, phenol, proteins, glycosides, and alkaloids. The LMOL has shown the presence of phenolic compounds, flavonoids, carbohydrates, proteins, amino acids, terpenoids and tannins. The FCCL has shown the presence of phenolic compounds, flavonoids, carbohydrates, terpenoids, glycosides, alkaloids and tannins. Total flavonoid content and phenolic content was present as gallic acid and Iso-quercetin respectively. The herbal tablet formulation was prepared by wet granulation method utilizing the different proportion of the plant extract. The evaluation of Herbal tablet formulation stated that HTF-3 formulation has shown the best result in pre-compression and post-compression parameters. The hydro ethanolic extract of LCPL, LMOL and FCCL show the presence of different flavonoid and phenolic content i.e., Iso-quercetin, gallic acid. The Three different batches of HTF were prepared and result data indicates that developed formulation has been approved, suitable for oral administration and pharmacological evaluation.