Pub Date : 2024-02-29DOI: 10.55522/jmpas.v13i1.5486
Bhawna Sharma
Neuro degenerative diseases (NDs) are a wide range of neurological conditions characterized by the deterioration of neurons, glial cells, synapses, and other networks. Parkinson’s disease is one of the second most common neuro degenerative disorders after Alzheimer’s disease. Erucic acid, an omega-9 monounsaturated fatty acid, was reported to be commonly present in mustard oil. Erucic acid was also reported to have neuro protective and antioxidant benefits in a number of pre-clinical trials conducted in the past. In the present study, erucic acid, linoleic acid, and Riluzole were evaluated using a molecular docking-based technique based on their binding affinities and other physico-chemical characteristics of the compounds. PYRX 0.8 was used for molecular docking between ligands and the various antioxidant and neurotransmitter-associated proteins, and Discovery Studio Visualizer 2020 was used to create the visualization. Additionally, Lipinski's rule of five was used to forecast whether these compounds would be drug-like. Further absorption, distribution, metabolism, excretion, and Toxicity (ADME-T) profile of the compounds were studied using the pkCSM tool. According to drug-likeness analysis, all of the compounds i.e. erucic acid, linoleic acid, and Riluzole fell within Lipinski's rule of five's acceptable range. The docking studies implied that erucic acid might have anti-parkinsonian effects by binding to molecular targets superoxide dismutase (SOD1) enzyme protein i.e. 5YTU and to 5-Hydroxytrytamine (5H2TC) receptor protein i.e. 6BQH when compared to Riluzole along with good ADME-T properties. However, more research is needed to evaluate the efficacy of erucic acid against additional targets of Parkinson’s disease and other neuro degenerative illnesses.
{"title":"Characterization and molecular docking studies of Erucic acid","authors":"Bhawna Sharma","doi":"10.55522/jmpas.v13i1.5486","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5486","url":null,"abstract":"Neuro degenerative diseases (NDs) are a wide range of neurological conditions\u0000 characterized by the deterioration of neurons, glial cells, synapses, and other\u0000 networks. Parkinson’s disease is one of the second most common neuro degenerative\u0000 disorders after Alzheimer’s disease. Erucic acid, an omega-9 monounsaturated fatty acid,\u0000 was reported to be commonly present in mustard oil. Erucic acid was also reported to\u0000 have neuro protective and antioxidant benefits in a number of pre-clinical trials\u0000 conducted in the past. In the present study, erucic acid, linoleic acid, and Riluzole\u0000 were evaluated using a molecular docking-based technique based on their binding\u0000 affinities and other physico-chemical characteristics of the compounds. PYRX 0.8 was\u0000 used for molecular docking between ligands and the various antioxidant and\u0000 neurotransmitter-associated proteins, and Discovery Studio Visualizer 2020 was used to\u0000 create the visualization. Additionally, Lipinski's rule of five was used to forecast\u0000 whether these compounds would be drug-like. Further absorption, distribution,\u0000 metabolism, excretion, and Toxicity (ADME-T) profile of the compounds were studied using\u0000 the pkCSM tool. According to drug-likeness analysis, all of the compounds i.e. erucic\u0000 acid, linoleic acid, and Riluzole fell within Lipinski's rule of five's acceptable\u0000 range. The docking studies implied that erucic acid might have anti-parkinsonian effects\u0000 by binding to molecular targets superoxide dismutase (SOD1) enzyme protein i.e. 5YTU and\u0000 to 5-Hydroxytrytamine (5H2TC) receptor protein i.e. 6BQH when compared to Riluzole along\u0000 with good ADME-T properties. However, more research is needed to evaluate the efficacy\u0000 of erucic acid against additional targets of Parkinson’s disease and other neuro\u0000 degenerative illnesses.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.55522/jmpas.v13i1.5928
Md. Nazneen Bobby
The current investigation was characterizing the pharmacognostical screening of the mother plant Albizia lebbeck and its in vitro propagated plantlets. The macroscopic analysis showed the presence of various parts of the plants and the anatomical studies revealed the presence of paracytic stomata of equal subsidiary cells; dendroid vein terminations; Thick–walled epidermal cells and parenchymatous ground tissue; cuticular projections with striations in the epidermal cells of a leaf; smaller vascular bundles with lateral veins; thick-walled bundle sheath fibers with thick vascular strands; irregularly lobed sclereids and tannin cells in the upper epidermis of lamina; druse idioblasts in the mesophyll of the leaf; accessory vascular bundles in the petiole were observed in the mother plant, which was compared with the in-vitro micro propagated plantlet with the presence of thick and wide midrib with lamina; Thick leaf margin with thin Phloem; short xylem; vascular showed reduced in size; Reduce palisade tissue; Thick and compact parenchyma; Squamish and papillate epidermal cells were observed in epidermal and stromata region. The current studies contribute as a standard monograph for the identification and evaluation of plants.
{"title":"Comparative morpho-anatomical studies of Albizia lebbeck (L.) Benth and in vitro\u0000 micro propagated plantlets","authors":"Md. Nazneen Bobby","doi":"10.55522/jmpas.v13i1.5928","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5928","url":null,"abstract":"The current investigation was characterizing the pharmacognostical screening of\u0000 the mother plant Albizia lebbeck and its in vitro propagated plantlets. The macroscopic\u0000 analysis showed the presence of various parts of the plants and the anatomical studies\u0000 revealed the presence of paracytic stomata of equal subsidiary cells; dendroid vein\u0000 terminations; Thick–walled epidermal cells and parenchymatous ground tissue; cuticular\u0000 projections with striations in the epidermal cells of a leaf; smaller vascular bundles\u0000 with lateral veins; thick-walled bundle sheath fibers with thick vascular strands;\u0000 irregularly lobed sclereids and tannin cells in the upper epidermis of lamina; druse\u0000 idioblasts in the mesophyll of the leaf; accessory vascular bundles in the petiole were\u0000 observed in the mother plant, which was compared with the in-vitro micro propagated\u0000 plantlet with the presence of thick and wide midrib with lamina; Thick leaf margin with\u0000 thin Phloem; short xylem; vascular showed reduced in size; Reduce palisade tissue; Thick\u0000 and compact parenchyma; Squamish and papillate epidermal cells were observed in\u0000 epidermal and stromata region. The current studies contribute as a standard monograph\u0000 for the identification and evaluation of plants.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.55522/jmpas.v13i1.5903
Udaya Chandrika P
The current research study aimed to study Isolated phytocompounds of Aspidopterys sps (A. indica and A.cordata) by invitro antihypertensive activity, in-silico molecular docking, and ADME/T analysis. The preceding reports had revealed a fact of polyphenols and triterpenoids have an ability to control blood pressure by inhibition of Angiotensin converting enzyme (ACE). The isolated ligands Catechin, Isoorientin, Fisetin, and Ursolic acid (A , B, C and D) tested for ACE inhibition, docked with target Human Angiotensin-converting enzyme employing Autodock 4.2, drug-likeliness, physicochemical nature, toxicity prediction by Swiss ADME, ProTox tools available online. All phytoconstituents showed optimistic dose-responsive inhibition, Compounds exhibited magnificent IC50 (15.38 ± 0.53) μg/ml, B (20.21± 0.34 μg/ml), C (17.62 ± 0.78 μg/ml), D (23.98 ± 0.65 μg/ml), Captopril (15.86±0.32 μg/ml). Molecule A showed utmost binding energy (-7.3 K.cal/mol) significant alignment with target protein and good interactions compared to Captopril (-6.7) and Lisinopril (-7.38 K.cal/mol). Prediction of ADME/T and ligands showed good pharmacokinetic properties characterized by high absorption in the gastrointestinal tract, oral bioavailability, and minimal toxicity and high binding energies, so these bioactive compounds could be further explored as possible antihypertensive drugs.
{"title":"In-silico approach: predictive ADME/T properties and ACE inhibitory action of\u0000 isolated compounds of Aspidopterys sps","authors":"Udaya Chandrika P","doi":"10.55522/jmpas.v13i1.5903","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5903","url":null,"abstract":"The current research study aimed to study Isolated phytocompounds of Aspidopterys\u0000 sps (A. indica and A.cordata) by invitro antihypertensive activity, in-silico molecular\u0000 docking, and ADME/T analysis. The preceding reports had revealed a fact of polyphenols\u0000 and triterpenoids have an ability to control blood pressure by inhibition of Angiotensin\u0000 converting enzyme (ACE). The isolated ligands Catechin, Isoorientin, Fisetin, and\u0000 Ursolic acid (A , B, C and D) tested for ACE inhibition, docked with target Human\u0000 Angiotensin-converting enzyme employing Autodock 4.2, drug-likeliness, physicochemical\u0000 nature, toxicity prediction by Swiss ADME, ProTox tools available online. All\u0000 phytoconstituents showed optimistic dose-responsive inhibition, Compounds exhibited\u0000 magnificent IC50 (15.38 ± 0.53) μg/ml, B (20.21± 0.34 μg/ml), C (17.62 ± 0.78 μg/ml), D\u0000 (23.98 ± 0.65 μg/ml), Captopril (15.86±0.32 μg/ml). Molecule A showed utmost binding\u0000 energy (-7.3 K.cal/mol) significant alignment with target protein and good interactions\u0000 compared to Captopril (-6.7) and Lisinopril (-7.38 K.cal/mol). Prediction of ADME/T and\u0000 ligands showed good pharmacokinetic properties characterized by high absorption in the\u0000 gastrointestinal tract, oral bioavailability, and minimal toxicity and high binding\u0000 energies, so these bioactive compounds could be further explored as possible\u0000 antihypertensive drugs.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.55522/jmpas.v13i1.5919
Laxman K Senapati
Although the subarachnoid block is the preferred anesthetic technique for the caesarean section, on the downside it is often associated with complications like maternal hypotension. We compared phenylephrine, norepinephrine, and mephentermine infusions to maintain blood pressure during the caesarian section under subarachnoid block. Our study included 240 parturients with singleton-term pregnancies undergoing a caesarian section under spinal anesthesia. Following spinal anesthesia till the delivery of the baby, parturients randomly assigned to three groups received phenylephrine, norepinephrine, and mephentermine infusions.Heart rate, blood pressure, intra-operative nausea and vomiting, neonatal Apgar score, and total rescue vasopressors required were analyzed. Except at 4 min (p=0.006), ANOVA revealed no statistically significant difference in systolic blood pressure between the groups across all time points. Systolic blood pressure showed a significant difference between the mephentermine group versus the phenylephrine group (p=0.013) and the norepinephrine group versus the phenylephrine group (p=0.022) at four minutes post hoc Bonferroni. Except at 15 and 60 minutes (p=0.02 and p=0.001, Refer This Article Amit Pradhan, Rasulata Swain, Priyadarsini Samanta, Laxman K Senapati, Ganesh C Satapathy, 2024. Comparison of infusions of phenylephrine, norepinephrine, and Mephentermine on maternal hemodynamics and neonatal outcomes in caesarean section under spinal anaesthesia. . Journal of medical pharmaceutical and allied sciences, V 13 - I 1, Pages- 6392 – 6400. Doi: https://doi.org/10.55522/jmpas.V13I1.5919.respectively), the mean heart rate was comparable among the three groups. The Chi-square test revealed no statistically significant difference in the requirement of rescue drugs among the groups (ϰ2=1.57, p=0.45) except at the time point of 4 minutes (p=0.01) when the highest requirement was observed in the phenylephrine group. The Apgar scores amongst the groups were comparable at 1 min (p=0.99) and 5 min (p=0.98). In the lower segment caesarian section under the subarachnoid block, infusions of phenylephrine, norepinephrine, and mephentermine were equally effective in managing maternal hypotension and achieving favorable neonatal outcomes.
虽然蛛网膜下腔阻滞是剖腹产的首选麻醉技术，但其缺点是经常会引起产妇低血压等并发症。我们比较了在蛛网膜下腔阻滞下进行剖腹产时输注苯肾上腺素、去甲肾上腺素和美芬丁胺以维持血压的情况。我们的研究包括 240 名在脊髓麻醉下进行剖腹产手术的单胎足月孕妇。研究分析了心率、血压、术中恶心和呕吐、新生儿Apgar评分以及所需的抢救性血管加压剂总量。方差分析显示，除 4 分钟（P=0.006）外，各组间收缩压在所有时间点的差异均无统计学意义。在 4 分钟时，收缩压在美芬特明组与苯肾上腺素组（P=0.013）和去甲肾上腺素组与苯肾上腺素组（P=0.022）之间存在显著差异，并进行了 Bonferroni 检验。除了在 15 分钟和 60 分钟时（P=0.02 和 P=0.001，参考本文 Amit Pradhan、Rasulata Swain、Priyadarsini Samanta、Laxman K Senapati、Ganesh C Satapathy，2024 年），苯肾上腺素组与去甲肾上腺素组相比（P=0.013），去甲肾上腺素组与苯肾上腺素组相比（P=0.022）。在脊髓麻醉下剖腹产时输注苯肾上腺素、去甲肾上腺素和美芬丁胺对产妇血流动力学和新生儿预后的影响比较。.Journal of medical pharmaceutical and allied sciences, V 13 - I 1, Pages- 6392 - 6400.Doi：https://doi.org/10.55522/jmpas.V13I1.5919.respectively），三组的平均心率相当。卡方检验显示，除了在 4 分钟（p=0.01）时，苯肾上腺素组对抢救药物的需求量最高外，其他各组对抢救药物的需求量在统计学上无显著差异（ϰ2=1.57，p=0.45）。各组在 1 分钟（p=0.99）和 5 分钟（p=0.98）时的 Apgar 评分相当。在蛛网膜下腔阻滞的下段剖腹产中，输注苯肾上腺素、去甲肾上腺素和美芬丁胺对控制产妇低血压和获得良好的新生儿预后同样有效。
{"title":"Comparison of infusions of phenylephrine, norepinephrine, and mephentermine on\u0000 maternal hemodynamics and neonatal outcomes in caesarean section under spinal\u0000 anaesthesia","authors":"Laxman K Senapati","doi":"10.55522/jmpas.v13i1.5919","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5919","url":null,"abstract":"Although the subarachnoid block is the preferred anesthetic technique for the\u0000 caesarean section, on the downside it is often associated with complications like\u0000 maternal hypotension. We compared phenylephrine, norepinephrine, and mephentermine\u0000 infusions to maintain blood pressure during the caesarian section under subarachnoid\u0000 block. Our study included 240 parturients with singleton-term pregnancies undergoing a\u0000 caesarian section under spinal anesthesia. Following spinal anesthesia till the delivery\u0000 of the baby, parturients randomly assigned to three groups received phenylephrine,\u0000 norepinephrine, and mephentermine infusions.Heart rate, blood pressure, intra-operative\u0000 nausea and vomiting, neonatal Apgar score, and total rescue vasopressors required were\u0000 analyzed. Except at 4 min (p=0.006), ANOVA revealed no statistically significant\u0000 difference in systolic blood pressure between the groups across all time points.\u0000 Systolic blood pressure showed a significant difference between the mephentermine group\u0000 versus the phenylephrine group (p=0.013) and the norepinephrine group versus the\u0000 phenylephrine group (p=0.022) at four minutes post hoc Bonferroni. Except at 15 and 60\u0000 minutes (p=0.02 and p=0.001, Refer This Article Amit Pradhan, Rasulata Swain,\u0000 Priyadarsini Samanta, Laxman K Senapati, Ganesh C Satapathy, 2024. Comparison of\u0000 infusions of phenylephrine, norepinephrine, and Mephentermine on maternal hemodynamics\u0000 and neonatal outcomes in caesarean section under spinal anaesthesia. . Journal of\u0000 medical pharmaceutical and allied sciences, V 13 - I 1, Pages- 6392 – 6400. Doi:\u0000 https://doi.org/10.55522/jmpas.V13I1.5919.respectively), the mean heart rate was\u0000 comparable among the three groups. The Chi-square test revealed no statistically\u0000 significant difference in the requirement of rescue drugs among the groups (ϰ2=1.57,\u0000 p=0.45) except at the time point of 4 minutes (p=0.01) when the highest requirement was\u0000 observed in the phenylephrine group. The Apgar scores amongst the groups were comparable\u0000 at 1 min (p=0.99) and 5 min (p=0.98). In the lower segment caesarian section under the\u0000 subarachnoid block, infusions of phenylephrine, norepinephrine, and mephentermine were\u0000 equally effective in managing maternal hypotension and achieving favorable neonatal\u0000 outcomes.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140416086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.55522/jmpas.v13i1.5741
Arshad Jamal Sayed
A higher implant failure rate may be associated with a lack of primary stability. Primary stability is a stationary, entirely mechanical parameter that determines when an implant is placed. Several methods have been developed to improve the primary implant's level of stability. However, Osseo-densification (OD) is a revolutionary implant preparation approach that addresses these issues and enhances the main stability of implants inserted into low-density bones. In light of this, the present systematic review was conducted to understand the Osseo-densification for preservation and compaction of alveolar bone in enhancing the stability of the dental implant. Research papers from PubMed, CINAHL, Web of Science, and Web of Science, Medline searched. The most recent literature suggests that using the Osseo-densification drilling protocol increases the overall value of implant insertion torque and, consequently, increases the primary stability of implants. To evaluate the caliber of the contained research, CARE, ARRIVE, and modified CONSORT checklists were employed. 133 full texts were chosen for further investigation after duplicates were removed and titles and abstracts were reviewed of these, 27 entire texts met the inclusion criteria. The thorough literature search identified 6 Case Studies & Case Series, 11 in vivo animal studies, and ten /experimental animal studies that noted the use of the Osseo-densification technique. The data from most recent animal in vivo/in vitro studies and case reports / case series suggest that Osseo-densification drilling protocol increases the overall value of implant insertion torque and, as a result, increases implant primary stability.
种植体失败率较高可能与缺乏初级稳定性有关。基底稳定性是一个固定的、完全机械的参数，它决定了何时植入种植体。目前已开发出多种方法来提高种植体的初次稳定性。然而，骨质致密化（OD）是一种革命性的种植体制备方法，它可以解决这些问题，并增强植入低密度骨骼的种植体的主要稳定性。有鉴于此，本系统性综述旨在了解 Osseo-densification（骨密度调整）在保护和压实牙槽骨以增强牙科植入物稳定性方面的作用。研究论文来自 PubMed、CINAHL、Web of Science 和 Web of Science、Medline。最新的文献表明，使用 Osseo 增密钻孔方案可以增加种植体插入扭矩的总体值，从而提高种植体的主要稳定性。为了评估所含研究的质量，我们采用了 CARE、ARRIVE 和修改后的 CONSORT 检查表。在剔除重复文献、审阅标题和摘要后，我们选择了 133 篇全文进行进一步调查，其中 27 篇全文符合纳入标准。通过全面的文献检索，确定了 6 项病例研究和病例系列研究、11 项体内动物研究和 10 项实验动物研究，这些研究都提到了 Osseo 骨密度技术的使用。最新的体内/体外动物研究和病例报告/病例系列的数据表明，Osseo-致密化钻孔方案可以增加种植体插入扭矩的总体值，从而增加种植体的初期稳定性。
{"title":"Osseo-densification for preservation and compaction of alveolar bone in enhancing\u0000 stability of dental implants: A systematic review","authors":"Arshad Jamal Sayed","doi":"10.55522/jmpas.v13i1.5741","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5741","url":null,"abstract":"A higher implant failure rate may be associated with a lack of primary stability.\u0000 Primary stability is a stationary, entirely mechanical parameter that determines when an\u0000 implant is placed. Several methods have been developed to improve the primary implant's\u0000 level of stability. However, Osseo-densification (OD) is a revolutionary implant\u0000 preparation approach that addresses these issues and enhances the main stability of\u0000 implants inserted into low-density bones. In light of this, the present systematic\u0000 review was conducted to understand the Osseo-densification for preservation and\u0000 compaction of alveolar bone in enhancing the stability of the dental implant. Research\u0000 papers from PubMed, CINAHL, Web of Science, and Web of Science, Medline searched. The\u0000 most recent literature suggests that using the Osseo-densification drilling protocol\u0000 increases the overall value of implant insertion torque and, consequently, increases the\u0000 primary stability of implants. To evaluate the caliber of the contained research, CARE,\u0000 ARRIVE, and modified CONSORT checklists were employed. 133 full texts were chosen for\u0000 further investigation after duplicates were removed and titles and abstracts were\u0000 reviewed of these, 27 entire texts met the inclusion criteria. The thorough literature\u0000 search identified 6 Case Studies & Case Series, 11 in vivo animal studies, and ten\u0000 /experimental animal studies that noted the use of the Osseo-densification technique.\u0000 The data from most recent animal in vivo/in vitro studies and case reports / case series\u0000 suggest that Osseo-densification drilling protocol increases the overall value of\u0000 implant insertion torque and, as a result, increases implant primary stability.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140415267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.55522/jmpas.v13i1.6039
Nisha Ms
In the medical field, the requirement for automated medical diagnosis software has risen as the application uses machine learning to facilitate health analysis from different data points from a patient comparing it with massive amounts of medical data to diagnose and prevent disease. The automated system can run multiple tests simultaneously and thus resulting to faster turnaround time and enables timely patient care along with higher accuracy and reliability. The irregularities in the small intestine villi’s structure cause various autoimmune disorders. So, this work aims to find a novel technique for the feature extraction of upper endoscopy images of celiac disease. We employed CLAHE (Contrast Limited Adaptive Histogram Equalization) for the preprocessing step and the Sobel operator with gradient magnitude for the segmentation of the enhanced image. In this manuscript, we have proposed a novel approach by calculating texture features through gray level co-occurrence matrix and frequency analysis using 3-level discrete wavelet transform decomposition on endoscopy images that renders novelty to the work. Thereafter, linear SVM (support vector machine) with PCA (Principal Component Analysis) is used for classification. The ensemble approach attains accuracy, sensitivity, and specificity of 78.49 %, 90.32 %, and 77.27% respectively. The outcomes achieved with the suggested approach are compared with some state-of-the-art methods using the same dataset. The results are promising due to high sensitivity for the treatment of untreated celiac disease and can prove boom to the medical industry by assisting clinicians to diagnose the disease at an early stage.
{"title":"Classification of celiac disease using novel approach of three-level DWT\u0000 decomposition and linear support vector machine","authors":"Nisha Ms","doi":"10.55522/jmpas.v13i1.6039","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.6039","url":null,"abstract":"In the medical field, the requirement for automated medical diagnosis software has\u0000 risen as the application uses machine learning to facilitate health analysis from\u0000 different data points from a patient comparing it with massive amounts of medical data\u0000 to diagnose and prevent disease. The automated system can run multiple tests\u0000 simultaneously and thus resulting to faster turnaround time and enables timely patient\u0000 care along with higher accuracy and reliability. The irregularities in the small\u0000 intestine villi’s structure cause various autoimmune disorders. So, this work aims to\u0000 find a novel technique for the feature extraction of upper endoscopy images of celiac\u0000 disease. We employed CLAHE (Contrast Limited Adaptive Histogram Equalization) for the\u0000 preprocessing step and the Sobel operator with gradient magnitude for the segmentation\u0000 of the enhanced image. In this manuscript, we have proposed a novel approach by\u0000 calculating texture features through gray level co-occurrence matrix and frequency\u0000 analysis using 3-level discrete wavelet transform decomposition on endoscopy images that\u0000 renders novelty to the work. Thereafter, linear SVM (support vector machine) with PCA\u0000 (Principal Component Analysis) is used for classification. The ensemble approach attains\u0000 accuracy, sensitivity, and specificity of 78.49 %, 90.32 %, and 77.27% respectively. The\u0000 outcomes achieved with the suggested approach are compared with some state-of-the-art\u0000 methods using the same dataset. The results are promising due to high sensitivity for\u0000 the treatment of untreated celiac disease and can prove boom to the medical industry by\u0000 assisting clinicians to diagnose the disease at an early stage.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140412818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.55522/jmpas.v13i1.5767
Kamal Eldin Ahmed Abdelsalam
Ephedra foeminea has been increasingly recognized for its anti-cancer properties. The current study evaluated the anti-oxidant and anti-cancer activities of the methanol extract of E. foeminea (EFME). The extract was evaluated for cytotoxic effects against mouse breast cancer 4T1 cells, and camptothecin was used as a standard anti-cancer drug for comparison. The anti-oxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effect while the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, cell invasion assay, scratch assay and cell cycle analysis were used for evaluation of its anti-cancer potential. In the MTT assay on 4T1 cells, viability was preserved at ≥86% when treated at 12.5 μg/ml, with an IC50 concentration of 40.09 μg/ml. Further, the extract increased the cell invasion in the invasion assay, while a reduced cell migration was observed in the scratch assay. Cell cycle analysis using flow cytometry demonstrated a good anti-cancer effect of EFME with cell cycle arrest in the G2/M phase. Moreover, a remarkable anti-oxidant effect was observed in the DPPH assay. These findings indicated the EFME exhibits significant anti-cancer, and anti-oxidant properties but the effects were observed at a higher concentration of 40.09 μg/ml.
{"title":"In-vitro evaluation of Epherda Foemenia for anti-oxidant and anti-cancer\u0000 properties","authors":"Kamal Eldin Ahmed Abdelsalam","doi":"10.55522/jmpas.v13i1.5767","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5767","url":null,"abstract":"Ephedra foeminea has been increasingly recognized for its anti-cancer properties.\u0000 The current study evaluated the anti-oxidant and anti-cancer activities of the methanol\u0000 extract of E. foeminea (EFME). The extract was evaluated for cytotoxic effects against\u0000 mouse breast cancer 4T1 cells, and camptothecin was used as a standard anti-cancer drug\u0000 for comparison. The anti-oxidant activity was determined by the\u0000 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effect while the\u0000 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, cell\u0000 invasion assay, scratch assay and cell cycle analysis were used for evaluation of its\u0000 anti-cancer potential. In the MTT assay on 4T1 cells, viability was preserved at ≥86%\u0000 when treated at 12.5 μg/ml, with an IC50 concentration of 40.09 μg/ml. Further, the\u0000 extract increased the cell invasion in the invasion assay, while a reduced cell\u0000 migration was observed in the scratch assay. Cell cycle analysis using flow cytometry\u0000 demonstrated a good anti-cancer effect of EFME with cell cycle arrest in the G2/M phase.\u0000 Moreover, a remarkable anti-oxidant effect was observed in the DPPH assay. These\u0000 findings indicated the EFME exhibits significant anti-cancer, and anti-oxidant\u0000 properties but the effects were observed at a higher concentration of 40.09\u0000 μg/ml.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.55522/jmpas.v13i1.5986
Bich Ngoc Giau Lu
Amaranthus tricolor L., Amaranthus spinosus L., and Amaranthus viridis L. are well-known for flavoring food products and traditional medicine. This study investigated the antioxidant and α-glucosidase inhibitory activity of various solvent fractions from the whole plant of A. tricolor, A. spinosus, and A. viridis in Vietnam. The total extract and solvent fractions of petroleum ether (PE), chloroform (CF), ethyl acetate (EA), n-butanol (B), and water (W) were tested for antioxidant activity using the DPPH assay and α-glucosidase inhibition. The results showed that the three species of Amaranthus had relatively low antioxidant activity, and the total extract of A. spinosus L. had the highest antioxidant activity with an IC50 value of 324.96 μg/mL. The EA fraction of A. tricolor had outstanding α-glucosidase inhibitory activity with an IC50 value of 95.94 μg/mL. It is recommended to continue isolation research to find active ingredients with α-glucosidase inhibition potential in the EA extract of A. tricolor. Additionally, an in vivo assay might be conducted to evaluate the activity and toxicity of this EA fraction.
三色苋（Amaranthus tricolor L.）、旋花苋（Amaranthus spinosus L.）和病毒苋（Amaranthus viridis L.）是著名的调味食品和传统药物。本研究调查了越南三色苋、旋花苋和病毒苋全草中各种溶剂馏分的抗氧化和α-葡萄糖苷酶抑制活性。采用 DPPH 法和α-葡萄糖苷酶抑制法测试了总提取物和石油醚（PE）、氯仿（CF）、乙酸乙酯（EA）、正丁醇（B）和水（W）等溶剂馏分的抗氧化活性。结果表明，这三种马齿苋的抗氧化活性相对较低，其中 A. spinosus L. 的总提取物的抗氧化活性最高，IC50 值为 324.96 μg/mL。A.tricolor的EA部分具有突出的α-葡萄糖苷酶抑制活性，IC50值为95.94 μg/mL。建议继续进行分离研究，以寻找三色金莲花 EA 提取物中具有α-葡萄糖苷酶抑制潜力的活性成分。此外，还可以进行体内试验，以评估这种 EA 提取物的活性和毒性。
{"title":"Antioxidant and α-Glucosidase inhibitory activity of various solvent fractions from\u0000 Amaranthus viridis L., Amaranthus tricolor L., and Amaranthus spinosus L.","authors":"Bich Ngoc Giau Lu","doi":"10.55522/jmpas.v13i1.5986","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5986","url":null,"abstract":"Amaranthus tricolor L., Amaranthus spinosus L., and Amaranthus viridis L. are\u0000 well-known for flavoring food products and traditional medicine. This study investigated\u0000 the antioxidant and α-glucosidase inhibitory activity of various solvent fractions from\u0000 the whole plant of A. tricolor, A. spinosus, and A. viridis in Vietnam. The total\u0000 extract and solvent fractions of petroleum ether (PE), chloroform (CF), ethyl acetate\u0000 (EA), n-butanol (B), and water (W) were tested for antioxidant activity using the DPPH\u0000 assay and α-glucosidase inhibition. The results showed that the three species of\u0000 Amaranthus had relatively low antioxidant activity, and the total extract of A. spinosus\u0000 L. had the highest antioxidant activity with an IC50 value of 324.96 μg/mL. The EA\u0000 fraction of A. tricolor had outstanding α-glucosidase inhibitory activity with an IC50\u0000 value of 95.94 μg/mL. It is recommended to continue isolation research to find active\u0000 ingredients with α-glucosidase inhibition potential in the EA extract of A. tricolor.\u0000 Additionally, an in vivo assay might be conducted to evaluate the activity and toxicity\u0000 of this EA fraction.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.55522/jmpas.v13i1.5888
N. Bhatia
The recognized root causes of breast cancer aggressiveness, resistance to therapy, and poor prognosis encompass hypoxia-inducible factors (HIFs), the HIF-dependent cancer hallmarks angiogenesis and metabolic reconfiguration.There is enough evidence to suggest that HIF is involved in the progression of breast cancer.Information for the network was gathered from the following databases: Dr. Duke's, IMPPAT, PubChem, Binding DB, UniProt, and DisGeNET. The network was created using the Cytoscapeprogramme. Screened bioactives having similarity index more than 0.6 from polypharmacology approach were subjected to docking studies with HIF-1 (PDB ID: 1H2K) with PyRx software and the ligands with good docking score was further explored for molecular docking interaction analysis. The number of bioactives having interaction with HIF-1, equal to or greater than 0.6 from Ashwagandh, Shatavari, Neem, Alsi seeds, Methi, Haldi, Ghritkumari, Yashtimadhu, and KadiPatta was 12, 9, 2, 6, 12, 11, 5, 10, and 3, respectively. On performing the docking against the target HIF-1for top molecules with Araboglycyrrhizin (-10.1kcal/mol), Asparanin-A (-9.2 kcal/mol), Shatavarin-I (-9.2 kcal/mol), Shatavarin-X (-9.1 kcal/mol), Somniferanolide (-9.1 kcal/mol), Somniferawithanolide (-9.7 kcal/mol), Trigofoenoside-A (-9.2 kcal/mol), Trigofoenoside-F (-9.4 kcal/mol), Trillin (-9.9 kcal/mol), and Withanolide (-9.2 kcal/mol), the binding energies and molecular interactions of the ligands were fairly good as compared with standard synthetic ligand Acriflavine (-7.6 kcal/mol). The study elucidated an in silico molecular mechanism of HIF-1 inhibition by various bioactive phytoconstituents from selected plants. Comprehending the logic behind anti-breast cancer action was made easier with the help of experimental evidence of the network findings.
{"title":"Network ethnopharmacological and molecular docking based evaluation of the\u0000 anti-breast cancer activity for ayurvedic botanicals acting on hypoxia-inducible\u0000 factor-1","authors":"N. Bhatia","doi":"10.55522/jmpas.v13i1.5888","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5888","url":null,"abstract":"The recognized root causes of breast cancer aggressiveness, resistance to therapy,\u0000 and poor prognosis encompass hypoxia-inducible factors (HIFs), the HIF-dependent cancer\u0000 hallmarks angiogenesis and metabolic reconfiguration.There is enough evidence to suggest\u0000 that HIF is involved in the progression of breast cancer.Information for the network was\u0000 gathered from the following databases: Dr. Duke's, IMPPAT, PubChem, Binding DB, UniProt,\u0000 and DisGeNET. The network was created using the Cytoscapeprogramme. Screened bioactives\u0000 having similarity index more than 0.6 from polypharmacology approach were subjected to\u0000 docking studies with HIF-1 (PDB ID: 1H2K) with PyRx software and the ligands with good\u0000 docking score was further explored for molecular docking interaction analysis. The\u0000 number of bioactives having interaction with HIF-1, equal to or greater than 0.6 from\u0000 Ashwagandh, Shatavari, Neem, Alsi seeds, Methi, Haldi, Ghritkumari, Yashtimadhu, and\u0000 KadiPatta was 12, 9, 2, 6, 12, 11, 5, 10, and 3, respectively. On performing the docking\u0000 against the target HIF-1for top molecules with Araboglycyrrhizin (-10.1kcal/mol),\u0000 Asparanin-A (-9.2 kcal/mol), Shatavarin-I (-9.2 kcal/mol), Shatavarin-X (-9.1 kcal/mol),\u0000 Somniferanolide (-9.1 kcal/mol), Somniferawithanolide (-9.7 kcal/mol), Trigofoenoside-A\u0000 (-9.2 kcal/mol), Trigofoenoside-F (-9.4 kcal/mol), Trillin (-9.9 kcal/mol), and\u0000 Withanolide (-9.2 kcal/mol), the binding energies and molecular interactions of the\u0000 ligands were fairly good as compared with standard synthetic ligand Acriflavine (-7.6\u0000 kcal/mol). The study elucidated an in silico molecular mechanism of HIF-1 inhibition by\u0000 various bioactive phytoconstituents from selected plants. Comprehending the logic behind\u0000 anti-breast cancer action was made easier with the help of experimental evidence of the\u0000 network findings.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.55522/jmpas.v13i1.6154
Su Djie to Rante
Hip replacement surgery, a significant orthopaedic intervention, is commonly undertaken to address hip pain stemming from aging or injury, particularly among elderly patients. The primary objective of this surgical procedure is to restore the patient's quality of life to its pre-operative state, enabling them to resume normal daily activities. Typically, the posterior approach has been the conventional surgical method for hip replacement, widely practiced both in Indonesia and globally. This evolving trend has sparked interest in comparing the effectiveness and outcomes of the anterior and posterior approaches, particularly concerning critical factors such as operating time, length of hospital stays, need for transfusion, and postoperative mobilization time. In pursuit of a comprehensive understanding, a study was conducted, focusing on patients who underwent hip replacement surgery at Siloam Kupang Hospital. The anterior approach was considered as the case group, while the posterior approach served as the control group. Surprisingly, the study did not identify any statistically significant differences in operating time and transfusion requirements between hip replacement surgeries utilizing the anterior approach and those employing the posterior approach. This suggests that, from a procedural standpoint, both approaches are comparable in terms of efficiency and blood management. However, when assessing postoperative outcomes, distinct trends emerged. The anterior approach demonstrated a notable advantage in terms of faster mobilization times, implying a quicker recovery and the potential for patients to regain their mobility sooner. On the other hand, the posterior approach exhibited a shorter hospital stay, suggesting a streamlined postoperative course. These findings contribute valuable insights to the ongoing discourse within the orthopaedic community regarding the merits of the anterior and posterior approaches in hip replacement surgery. As medical practices continue to evolve, such comparative studies play a pivotal role in refining surgical techniques and optimizing patient outcomes in the realm of orthopaedic interventions.
{"title":"Comparative Analysis of Anterior and Posterior Approaches in Hip Replacement\u0000 Surgery: Enhancing Patient Efficiency","authors":"Su Djie to Rante","doi":"10.55522/jmpas.v13i1.6154","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.6154","url":null,"abstract":"Hip replacement surgery, a significant orthopaedic intervention, is commonly\u0000 undertaken to address hip pain stemming from aging or injury, particularly among elderly\u0000 patients. The primary objective of this surgical procedure is to restore the patient's\u0000 quality of life to its pre-operative state, enabling them to resume normal daily\u0000 activities. Typically, the posterior approach has been the conventional surgical method\u0000 for hip replacement, widely practiced both in Indonesia and globally. This evolving\u0000 trend has sparked interest in comparing the effectiveness and outcomes of the anterior\u0000 and posterior approaches, particularly concerning critical factors such as operating\u0000 time, length of hospital stays, need for transfusion, and postoperative mobilization\u0000 time. In pursuit of a comprehensive understanding, a study was conducted, focusing on\u0000 patients who underwent hip replacement surgery at Siloam Kupang Hospital. The anterior\u0000 approach was considered as the case group, while the posterior approach served as the\u0000 control group. Surprisingly, the study did not identify any statistically significant\u0000 differences in operating time and transfusion requirements between hip replacement\u0000 surgeries utilizing the anterior approach and those employing the posterior approach.\u0000 This suggests that, from a procedural standpoint, both approaches are comparable in\u0000 terms of efficiency and blood management. However, when assessing postoperative\u0000 outcomes, distinct trends emerged. The anterior approach demonstrated a notable\u0000 advantage in terms of faster mobilization times, implying a quicker recovery and the\u0000 potential for patients to regain their mobility sooner. On the other hand, the posterior\u0000 approach exhibited a shorter hospital stay, suggesting a streamlined postoperative\u0000 course. These findings contribute valuable insights to the ongoing discourse within the\u0000 orthopaedic community regarding the merits of the anterior and posterior approaches in\u0000 hip replacement surgery. As medical practices continue to evolve, such comparative\u0000 studies play a pivotal role in refining surgical techniques and optimizing patient\u0000 outcomes in the realm of orthopaedic interventions.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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