Metal-based nanoparticles in the treatment of infectious diseases

Q3 Engineering Nanoscience and Nanotechnology - Asia Pub Date : 2023-09-12 DOI:10.2174/2210681213666230912144049

Popat Kumbhar, Onkar Patil, Preeti Karade, Rajdeep Bhokare, Gaurav Gupta, Sachin Kumar Singh, Kamal Dua, John Disouza, Vandana Patravale

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Abstract

Abstract: Infectious diseases caused by different pathogens are responsible for high mortality across the globe. Multi-drug resistance (MDR) of microorganisms towards different antibiotics has posed a great challenge in treating infectious diseases efficiently. The metal-based nanoparticles (MNPs) have demonstrated great promise in treating infectious diseases because of their inherent antimicrobial potential. Besides, these NPs show site-specific delivery of antibiotic therapeutics, thereby minimizing dose, dose frequency, and side effects. Further, the synergistic effect of MNPs with an antibiotic can reduce the MDR. However, the fabrication of MNPs using an apt fabrication technique with proper control of charge, size, and morphology is highly required to achieve better therapeutic performance. This review focuses on MNPs as a potential avenue to treat infectious diseases. The role of MNPs in combating MDR, different sorts of MNPs, and their fabrication techniques are discussed. Furthermore, assorted types of MNPs employed in antibiotic delivery to treat infectious diseases are discussed with manifold case studies. In short, MNPs alone or as a carrier of antibiotics seems to be an effective strategy in wiping out infectious diseases.

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金属基纳米颗粒在传染病治疗中的应用

摘要:由不同病原体引起的传染病是造成全球高死亡率的原因。微生物对不同抗生素的多重耐药(MDR)给传染病的有效治疗带来了巨大挑战。金属基纳米颗粒(MNPs)由于其固有的抗菌潜力，在治疗感染性疾病方面显示出巨大的希望。此外，这些NPs显示抗生素治疗的部位特异性递送，从而最大限度地减少剂量、剂量频率和副作用。此外，MNPs与抗生素的协同作用可以减少耐多药。然而，为了获得更好的治疗性能，需要使用适当控制电荷、尺寸和形态的apt制造技术来制造MNPs。这篇综述的重点是MNPs作为治疗传染病的潜在途径。讨论了MNPs在抗MDR中的作用、不同种类的MNPs及其制备技术。此外，各种类型的MNPs应用于抗生素递送治疗传染病的多种案例研究进行了讨论。简而言之，MNPs单独或作为抗生素的载体似乎是消灭传染病的有效策略。

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来源期刊

Nanoscience and Nanotechnology - Asia Engineering-Engineering (all)

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Nanoscience & Nanotechnology-Asia publishes expert reviews, original research articles, letters and guest edited issues on all the most recent advances in nanoscience and nanotechnology with an emphasis on research in Asia and Japan. All aspects of the field are represented including chemistry, physics, materials science, biology and engineering mainly covering the following; synthesis, characterization, assembly, theory, and simulation of nanostructures (nanomaterials and assemblies, nanodevices, nano-bubbles, nano-droplets, nanofluidics, and self-assembled structures), nanofabrication, nanobiotechnology, nanomedicine and methods and tools for nanoscience and nanotechnology.