Associations of thyroid status and thyroperoxidase antibodies with serum trace elements

A. A. Serikbayeva, Z. B. Tauesheva, L. V. Shcherbakova, O. D. Rymar
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Abstract

BACKGROUND: Studies on the relationship between thyroid autoimmunity and serum trace elements (TE) are ongoing in different parts of the world, however, the data obtained are often contradictory, which determines the relevance of this study. AIM: The aim of the study was to identify associations between thyroid status and Anti-Thyroid Peroxidase antibodies (TPOAb) with serum TE among young women. MATERIALS AND METHODS: The study participants were 859 women aged 18–45, whose Thyroid-Stimulating Hormone (TSH) was in the reference range or above 3.4 µIU/ml and with free Thyroxine (fT4) in the reference range. The exclusion criteria were the presence of menopause and decompensation of chronic diseases. The participants were subdivided into 2 groups: a group of women with TPOAb less than 30 U/ml, designated as TPOAb(-), and a group of women with TPOAb more than 30 U/m, designated as TPOAb (+). The detection of TSH, fT4, and TPOAb in serum was provided by enzyme immunoassay on the Evolis Robotized System using “Thyroid — ELISA- TSH, 0.23–3.4 µIU/ml”, “Thyroid — ELISA free T4, 10–23.2 pmol/l”, “Thyroid ELISA — TPOAb<30 U/ml” test systems. The reference values were taken from the instructions of the manufacturer Alkor Bio group (Russia). Logistic regression analysis was applied to adjudge associations between TPOAb status and serum trace elements. RESULTS: The level of fT4 was lower in the AT-TPO (+) group compared to the AT-TPO (-), p=0.006; Triglycerides, aspartate aminotransferase, alkaline phosphatase was higher in the AT-TPO (+) group compared to the AT-TPO (-). There were more smoking women in the AT-TPO group (-) 4.1% versus 1.3% in AT-TPO (+). It was found that, after adjusting for likely cofounding factors, participants with antibody positivity had significantly lower concentrations of selenium; zinc, iodine, iron. When serum trace elements levels were analyzed in tertiles, the odds ratios TPOAb positivity of tertile 1 were higher that of tertile 3. CONCLUSION: The associations between TPOAb and microelements demonstrate their involvement in autoimmune processes in the thyroid gland.
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甲状腺状态和甲状腺过氧化物酶抗体与血清微量元素的关系
背景:关于甲状腺自身免疫与血清微量元素(TE)之间关系的研究正在世界各地进行,然而,所获得的数据往往相互矛盾,这决定了本研究的相关性。目的:该研究的目的是确定年轻女性甲状腺状态和抗甲状腺过氧化物酶抗体(TPOAb)与血清TE之间的关系。材料与方法:研究对象为859名年龄在18-45岁之间的女性,她们的促甲状腺激素(TSH)在参考范围内或高于3.4 μ IU/ml,游离甲状腺素(fT4)在参考范围内。排除标准为绝经和慢性疾病失代偿的存在。参与者被细分为两组:TPOAb低于30 U/ml的一组称为TPOAb(-), TPOAb大于30 U/m的一组称为TPOAb(+)。血清中TSH、fT4和TPOAb的检测采用Evolis Robotized System上的酶免疫分析法,采用“Thyroid - ELISA- TSH, 0.23-3.4 μ IU/ml”、“Thyroid - ELISA游离T4, 10-23.2 pmol/l”、“Thyroid ELISA- TPOAb<30 U/ml”检测系统。参考值取自生产商Alkor Bio group (Russia)的说明。采用Logistic回归分析判断TPOAb水平与血清微量元素的相关性。结果:AT-TPO(+)组fT4水平低于AT-TPO(-)组,p=0.006;AT-TPO(+)组甘油三酯、天冬氨酸转氨酶、碱性磷酸酶均高于AT-TPO(-)组。在AT-TPO组中吸烟的女性较多(- 4.1%),在AT-TPO组中吸烟的女性较多(+ 1.3%)。结果发现,在调整了可能的共同因素后,抗体阳性的参与者硒浓度显著降低;锌,碘,铁。在分析各组血清微量元素水平时,各组1的TPOAb阳性比值比高于各组3。结论:TPOAb和微量元素之间的关联表明它们参与甲状腺自身免疫过程。
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Associations of thyroid status and thyroperoxidase antibodies with serum trace elements Features of achieving compensation of hypothyroisis in pregnant women Structural and morphologic characteristics of nodular goiter in chronic iodine deficiency status Investigation of neural network models application in EU-TIRADS thyroid nodules classification for personalization of thyroid gland ultrasound diagnostic Press release from the Endocrine Society ENDO 2022 Annual Conference
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