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Associations of thyroid status and thyroperoxidase antibodies with serum trace elements 甲状腺状态和甲状腺过氧化物酶抗体与血清微量元素的关系
Pub Date : 2023-10-12 DOI: 10.14341/ket12762
A. A. Serikbayeva, Z. B. Tauesheva, L. V. Shcherbakova, O. D. Rymar
BACKGROUND: Studies on the relationship between thyroid autoimmunity and serum trace elements (TE) are ongoing in different parts of the world, however, the data obtained are often contradictory, which determines the relevance of this study. AIM: The aim of the study was to identify associations between thyroid status and Anti-Thyroid Peroxidase antibodies (TPOAb) with serum TE among young women. MATERIALS AND METHODS: The study participants were 859 women aged 18–45, whose Thyroid-Stimulating Hormone (TSH) was in the reference range or above 3.4 µIU/ml and with free Thyroxine (fT4) in the reference range. The exclusion criteria were the presence of menopause and decompensation of chronic diseases. The participants were subdivided into 2 groups: a group of women with TPOAb less than 30 U/ml, designated as TPOAb(-), and a group of women with TPOAb more than 30 U/m, designated as TPOAb (+). The detection of TSH, fT4, and TPOAb in serum was provided by enzyme immunoassay on the Evolis Robotized System using “Thyroid — ELISA- TSH, 0.23–3.4 µIU/ml”, “Thyroid — ELISA free T4, 10–23.2 pmol/l”, “Thyroid ELISA — TPOAb<30 U/ml” test systems. The reference values were taken from the instructions of the manufacturer Alkor Bio group (Russia). Logistic regression analysis was applied to adjudge associations between TPOAb status and serum trace elements. RESULTS: The level of fT4 was lower in the AT-TPO (+) group compared to the AT-TPO (-), p=0.006; Triglycerides, aspartate aminotransferase, alkaline phosphatase was higher in the AT-TPO (+) group compared to the AT-TPO (-). There were more smoking women in the AT-TPO group (-) 4.1% versus 1.3% in AT-TPO (+). It was found that, after adjusting for likely cofounding factors, participants with antibody positivity had significantly lower concentrations of selenium; zinc, iodine, iron. When serum trace elements levels were analyzed in tertiles, the odds ratios TPOAb positivity of tertile 1 were higher that of tertile 3. CONCLUSION: The associations between TPOAb and microelements demonstrate their involvement in autoimmune processes in the thyroid gland.
背景:关于甲状腺自身免疫与血清微量元素(TE)之间关系的研究正在世界各地进行,然而,所获得的数据往往相互矛盾,这决定了本研究的相关性。目的:该研究的目的是确定年轻女性甲状腺状态和抗甲状腺过氧化物酶抗体(TPOAb)与血清TE之间的关系。材料与方法:研究对象为859名年龄在18-45岁之间的女性,她们的促甲状腺激素(TSH)在参考范围内或高于3.4 μ IU/ml,游离甲状腺素(fT4)在参考范围内。排除标准为绝经和慢性疾病失代偿的存在。参与者被细分为两组:TPOAb低于30 U/ml的一组称为TPOAb(-), TPOAb大于30 U/m的一组称为TPOAb(+)。血清中TSH、fT4和TPOAb的检测采用Evolis Robotized System上的酶免疫分析法,采用“Thyroid - ELISA- TSH, 0.23-3.4 μ IU/ml”、“Thyroid - ELISA游离T4, 10-23.2 pmol/l”、“Thyroid ELISA- TPOAb<30 U/ml”检测系统。参考值取自生产商Alkor Bio group (Russia)的说明。采用Logistic回归分析判断TPOAb水平与血清微量元素的相关性。结果:AT-TPO(+)组fT4水平低于AT-TPO(-)组,p=0.006;AT-TPO(+)组甘油三酯、天冬氨酸转氨酶、碱性磷酸酶均高于AT-TPO(-)组。在AT-TPO组中吸烟的女性较多(- 4.1%),在AT-TPO组中吸烟的女性较多(+ 1.3%)。结果发现,在调整了可能的共同因素后,抗体阳性的参与者硒浓度显著降低;锌,碘,铁。在分析各组血清微量元素水平时,各组1的TPOAb阳性比值比高于各组3。结论:TPOAb和微量元素之间的关联表明它们参与甲状腺自身免疫过程。
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引用次数: 0
Features of achieving compensation of hypothyroisis in pregnant women 孕妇甲状腺功能减退实现代偿的特点
Pub Date : 2023-09-12 DOI: 10.14341/ket12743
E. G. Yakubova
BACKGROUND: Hypofunction of the thyroid gland in women at the pre-pregnancy stage and during pregnancy is associated with a high risk of congenital hypothyroidism in children, as a result of which irreversible changes in the nervous system are formed. Despite the mandatory intake of potassium iodide preparations, pregnant women often develop gestational hypothyroidism, which requires the appointment of levothyroxine. Many women have episodic hypofunction of the thyroid gland before pregnancy, associated with various factors. Diagnosed hypothyroidism requires hormonal correction. The recommended dose of levothyroxine calculated by the patient’s weight is not always adequate to achieve TSH targets. In addition, there are pharmacological factors. Levothyroxine sodium preparations differ in bioavailability. The stability of drugs is affected by external factors and the composition of fillers from different manufacturers of drugs. AIM: To assess the dependence of TSH reduction on the method of taking levothyroxine in a population of pregnant women. MATERIALS AND METHODS: Statistical analysis and prospective study was carried out from 2019 to 2021. On the basis of the «Perinatal Center», Tyumen, women’s consultative and diagnostic department. Pregnant women with diagnosed primary subclinical and manifest hypothyroidism in the first trimester of pregnancy (n=76) were selected for cohort observation. All pregnant women were prescribed L-thyroxine Berlin-hemi. Other levothyroxine preparations were not used in order to exclude distortion of the results of the study. RESULTS: Pregnant women with hypothyroidism were divided into two groups according to the method of taking L-thyroxine: oral (n=54) and sublingual (n=22). A month later, TSH normalization was observed in 41 pregnant women in the oral group (76%) and in 22 pregnant women in the sublingual group (100%). Women who did not achieve hypothyroidism compensation were recommended sublingual administration without increasing the dose of L-thyroxine, provided that TSH was no higher than 4.0 mcME / ml. A TSH study a month later showed that all pregnant women achieved compensation. CONCLUSION: Based on the conducted research, it is shown that the more rational administration of levothyroxine sodium preparations is sublingual, since there is a slightly alkaline reaction in the oral cavity, which does not have a destructive effect, like gastric juice.
背景:孕前和孕期妇女甲状腺功能减退与儿童先天性甲状腺功能减退的高风险相关,其结果是神经系统形成不可逆转的变化。尽管强制摄入碘化钾制剂,孕妇经常出现妊娠甲状腺功能减退,这需要预约左甲状腺素。许多妇女在怀孕前有偶发性甲状腺功能减退,与各种因素有关。诊断为甲状腺功能减退需要激素矫正。根据患者体重计算的左旋甲状腺素的推荐剂量并不总是足以达到TSH目标。此外,还有药理因素。左甲状腺素钠制剂的生物利用度不同。药物的稳定性受到外部因素和不同药品生产厂家的填料组成的影响。目的:评价孕妇TSH降低对左旋甲状腺素服用方法的依赖性。材料与方法:2019 - 2021年进行统计分析和前瞻性研究。在秋明“围产期中心”的基础上,妇女咨询和诊断部门。选择妊娠早期诊断为原发性亚临床和明显甲状腺功能减退的孕妇(76例)进行队列观察。所有孕妇均给予l -甲状腺素柏林半。没有使用其他左甲状腺素制剂,以排除研究结果的失真。结果:根据l -甲状腺素给药方法将甲状腺功能减退孕妇分为口服(54例)和舌下(22例)两组。1个月后,口服组41例(76%)和舌下组22例(100%)孕妇TSH恢复正常。在TSH不高于4.0 mcME / ml的情况下,没有达到甲状腺功能减退补偿的妇女建议舌下给药,而不增加l -甲状腺素的剂量。一个月后的TSH研究表明所有孕妇都达到了补偿。结论:根据所进行的研究,左甲状腺素钠制剂舌下给药更为合理,因为口腔内有微碱性反应,不像胃液那样具有破坏性作用。
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引用次数: 0
Investigation of neural network models application in EU-TIRADS thyroid nodules classification for personalization of thyroid gland ultrasound diagnostic 神经网络模型在EU-TIRADS甲状腺结节分类中应用于甲状腺超声诊断个体化的研究
Pub Date : 2023-09-12 DOI: 10.14341/ket12757
K. V. Tsyguleva, I. A. Lozhkin, D. V. Korolev, K. S. Zajcev, M. E. Dunaev, A. A. Garmash, A. V. Manaev, S. M. Zaharova, A. A. Trukhin, E. A. Troshina
SUBSTANTIATION. It is known that about 69% of all thyroid nodules undergoing surgical treatment are benign formations, and up to 75% of patients with an intermediate cytological conclusion undergo unnecessary surgical intervention. This suggests that improving the quality of differential diagnosis of nodular formations will avoid excessive economic costs for the healthcare system. In this regard, AI technologies in diagnostic algorithms for the classification of thyroid nodules were involved. AIM. Improving the efficiency of automatic classification of thyroid nodules on ultrasound images by using a set of neural network models. MATERIALS AND METHODS. We used ultrasound images of thyroid nodules available in open sources and obtained with the help of 3 ultrasound devices of Endocrinology Research Centre as part of Project № 22-15-00135 of the grant of the Russian Science Foundation. This article check the hypothesis that the size of the training set cannot be increased by repeating similar images from the ultrasound cine loop of one patient, but only by expanding the dataset with new unique specimens of other patients and/or data from the augmentation process. RESULTS. As a result, a neural network model EfficientNet-B6 was proposed to solve the problem of EU-TIRADS classification of thyroid nodules based on ultrasound images of the thyroid gland. CONCLUSION. The results obtained allow us to advance in the use of artificial intelligence methods for personalized medicine in thyroid diseases.
实体化。众所周知,接受手术治疗的甲状腺结节中约有69%为良性形成,高达75%的细胞学结论为中等的患者接受了不必要的手术干预。这表明,提高结节形成的鉴别诊断质量将避免医疗保健系统的过度经济成本。在这方面,涉及人工智能技术在甲状腺结节分类诊断算法。的目标。利用一组神经网络模型提高超声图像上甲状腺结节自动分类的效率。材料和方法。我们使用了公开来源的甲状腺结节的超声图像,并在内分泌研究中心的3台超声设备的帮助下获得,这是俄罗斯科学基金会资助的项目№22-15-00135的一部分。本文验证了一个假设,即训练集的大小不能通过重复来自一个患者的超声电影循环的类似图像来增加,而只能通过使用其他患者的新的独特样本和/或来自增强过程的数据来扩展数据集。结果。为此,提出神经网络模型EfficientNet-B6,解决基于甲状腺超声图像的EU-TIRADS对甲状腺结节的分类问题。结论。获得的结果使我们能够在使用人工智能方法进行甲状腺疾病的个性化医疗方面取得进展。
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引用次数: 0
Structural and morphologic characteristics of nodular goiter in chronic iodine deficiency status 慢性缺碘状态下结节性甲状腺肿的结构和形态学特征
Pub Date : 2023-09-12 DOI: 10.14341/ket12748
E. A. Troshina, N. P. Makolina, E. A. Kolpakova, P. A. Nikiforovich, M. P. Isaeva, F. M. Abdulkhabirova, N. M. Platonova
OBJECTIVES . Diffuse and nodular goiter are the most common thyroid gland (thyroid) diseases in children and adults living in iodine-deficient regions. Thyroid hormone potentiates progressive hypertrophy and hyperplasia of thyrocytes, with uneven proliferation of thyroid cells leading to nodule formation. Iodine deficiency, which promotes replication of thyroid follicular cells, also increases the incidence of TSH Receptor mutations, leading to receptor activation and autonomous functioning of follicles. AIM . To evaluate and describe ultrasound and cytologic thyroid nodes in the regions in Russia with proven iodine deficiency. MATERIALS AND METHODS . The study was conducted in regions with proven iodine deficiency in the Central and North Caucasian Federal Districts. Population of conditionally healthy adult volunteers (mean age — 47.5 years) was recruited as part of visiting events to screen for the occurrence of thyroid nodes. RESULTS . The results obtained indicate a high prevalence of multinodular colloid goiter in adult patients living in conditions of chronic iodine deficiency. In the Chechen Republic, the prevalence of nodular thyroid pathology was found in 64.5% (205/318) of cases, and in the Tula region — in 40.6% (116/286). In the studied sample the results of cytologic examination confirmed the presence of colloid thyroid masses in 97% (60/62) — Bethesda category II; in 3% (2/62) of patients nodular masses had Bethesda IV. Diffuse goiter prevalence in the examined population was 20.8%. CONCLUSIONS . A study indicates a high prevalence of iodine-deficient thyroid disease — multinodular colloid goiter in regions with proven chronic iodine deficiency. The wide prevalence of goiter with colloid and cystic components is confirmed by the cytologic examination with different ultrasound characteristics according to the EU-TIRADS classification. The obtained data correspond to the official statistics demonstrating high prevalence of nontoxic goiter in adults in the examined regions, which is an important argument confirming the need for systemic iodine prophylaxis.
目标。弥漫性和结节性甲状腺肿是生活在缺碘地区的儿童和成人最常见的甲状腺(甲状腺)疾病。甲状腺激素促进甲状腺细胞进行性肥大和增生,甲状腺细胞增殖不均匀导致结节形成。缺碘会促进甲状腺滤泡细胞的复制,也会增加TSH受体突变的发生率,导致受体激活和滤泡的自主功能。的目标。评估和描述超声和细胞学甲状腺淋巴结在俄罗斯地区证实碘缺乏症。材料和方法。该研究是在中高加索和北高加索联邦区已证实缺碘的地区进行的。有条件的健康成人志愿者(平均年龄- 47.5岁)被招募作为访问活动的一部分,以筛查甲状腺淋巴结的发生。结果。结果表明,多结节性胶体甲状腺肿在慢性碘缺乏的成年患者中有很高的患病率。在车臣共和国,甲状腺结节病的患病率为64.5%(205/318),在图拉地区为40.6%(116/286)。在所研究的样本中,细胞学检查结果证实97%(60/62)存在胶体甲状腺肿块- Bethesda II类;3%(2/62)的患者结节性肿块为Bethesda IV型。弥漫性甲状腺肿在检查人群中的患病率为20.8%。结论。一项研究表明,碘缺乏性甲状腺疾病-多结节性胶体甲状腺肿在慢性碘缺乏症地区的患病率很高。根据EU-TIRADS分类,不同超声特征的细胞学检查证实了具有胶质和囊性成分的甲状腺肿的广泛流行。获得的数据与官方统计数据相符,表明在检查地区的成年人中无毒甲状腺肿的患病率很高,这是确认需要进行全身碘预防的重要论据。
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引用次数: 0
Press release from the Endocrine Society ENDO 2022 Annual Conference 内分泌学会ENDO 2022年年会新闻稿
Pub Date : 2023-07-31 DOI: 10.14341/ket12761
A. Editorial
ENDO 2022 — the key international event dedicated to endocrine diseases — was held in June 2022. This article provides a brief overview of the event and is focused on the thyroid disease.
ENDO 2022是致力于内分泌疾病的重要国际活动,于2022年6月举行。这篇文章提供了一个简要的概述事件,并集中在甲状腺疾病。
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引用次数: 0
Drug forms of levothyroxine. Is there room for innovation in hypothyroidism treatment? 左甲状腺素的药物形式。甲状腺功能减退的治疗还有创新的空间吗?
Pub Date : 2023-07-14 DOI: 10.14341/ket12759
© Е.А. Колпакова, А.А. Вознесенская, Н.В. Фролкова, Е. А. Трошина, E. A. Kolpakova, A. A. Voznesenskaya, N. V. Frolkova, E. Troshina
Levothyroxine steadily maintains its position as the «gold standard» in the treatment of hypothyroidism. Despite the possibility of step-by-step tableted dose titration of levothyroxine, the results of many studies reliably point to the fact that a significant number of patients do not reach the target level of thyroid hormone. One of the main reasons for the therapy ineffectiveness is the inconvenience of levothyroxine sodium regimen for many patients, associated with the need to observe certain time intervals before meals and other medications. The above-mentioned factors have stimulated a number of studies aimed at developing new dosage forms with significant advantages in the pharmacokinetics and pharmacodynamics of drugs. The review provides the latest data on the new dosage forms of levothyroxine. Further large-scale clinical trials are needed for a more reasonable and widespread use of new dosage forms of levothyroxine in clinical practice.
左甲状腺素稳定地保持其作为治疗甲状腺功能减退的“金标准”的地位。尽管左甲状腺素有可能逐步片剂量滴定,但许多研究结果可靠地指出,相当多的患者甲状腺激素未达到目标水平。治疗无效的主要原因之一是左旋甲状腺素钠治疗方案对许多患者不方便,需要在饭前和其他药物治疗前观察一定的时间间隔。上述因素刺激了许多旨在开发在药物的药代动力学和药效学方面具有显著优势的新剂型的研究。本综述提供了关于左甲状腺素新剂型的最新数据。为了在临床实践中更合理、更广泛地使用新剂型的左甲状腺素,还需要进一步的大规模临床试验。
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引用次数: 0
Difficulties in diagnosing subacute thyroiditis during COVID-19 pandemic COVID-19大流行期间亚急性甲状腺炎的诊断困难
Pub Date : 2023-07-13 DOI: 10.14341/ket12753
© В.В. Титова, Т. Ю. Демидова, И.С. Чернышева, Victoria V. Тitova, T. Demidova, Irina S. Chernysheva
Subacute thyroiditis is an inflammatory disease of the thyroid gland. Clinical manifestations include pain or discomfort in the neck, a painful diffuse goiter, and a transient episode of hyperthyroidism. We describe the case of a 48-year-old woman who had no symptoms characteristic of subacute thyroiditis. The test results were consistent with a clinical diagnosis of secondary hypothyroidism. The patient had a history of asymptomatic COVID-19 episode 6 months ago and neck pain one month ago. This case demonstrates the importance of a detailed history, comprehensive examination, and correct interpretation of laboratory and instrumental findings in making the diagnosis.
亚急性甲状腺炎是一种甲状腺炎症性疾病。临床表现包括颈部疼痛或不适,疼痛性弥漫性甲状腺肿和一过性甲状腺功能亢进。我们描述了一个48岁的妇女谁没有亚急性甲状腺炎的症状特征的情况下。试验结果与继发性甲状腺功能减退的临床诊断一致。患者6个月前有无症状的COVID-19发作史,1个月前颈部疼痛。这个病例说明了详细病史、全面检查和正确解释实验室和仪器检查结果在诊断中的重要性。
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引用次数: 0
Compression syndrome in giant euthyroid goiter 巨大甲状腺正常甲状腺肿的压迫综合征
Pub Date : 2023-07-13 DOI: 10.14341/ket12752
Кочина, ассистент Анна Сергеевна, MD Anna S. Kochina, д.м.н. профессор Демидова Татьяна Юльевна, T. Demidova
Given the widespread iodine deficiency, diffuse and diffuse nodular euthyroid goiter is an urgent problem. A large goiter needs to be highlighted both from the perspective of possible complications for the patient, including a decrease in the quality of life and compression syndrome, as well as from the perspective of the complexity of surgical treatment, given the technical complexity of the operation and the high probability of intraoperative and postoperative complications. The article describes a clinical case of a patient admitted to the endocrinology department with a diagnosis of diffuse nodular goiter of the 2nd degree for examination with complaints of a huge deforming formation of the neck contours, difficulty breathing when walking and during sleep. It is known from the anamnesis that the patient has been observed for about 10 years by an endocrinologist with nodular goiter. The patient was repeatedly offered surgical treatment, which he categorically refused. In the Department of endocrinology, the patient underwent a comprehensive examination to assess the condition and function of the thyroid gland, as well as to identify possible complications.
由于普遍缺碘,弥漫性和弥漫性结节性甲状腺肿是一个迫切需要解决的问题。无论是从患者可能出现的并发症(包括生活质量下降和压迫综合征)的角度,还是从手术治疗的复杂性的角度,都需要强调大甲状腺肿,因为手术的技术复杂性以及术中和术后并发症的高概率。本文描述了一个临床病例,患者入院内分泌科诊断为2度弥漫性结节性甲状腺肿检查,主诉颈部轮廓巨大变形,行走和睡眠时呼吸困难。从记忆中可以得知,内分泌学家已经观察了患者约10年的结节性甲状腺肿。病人多次接受手术治疗,但他断然拒绝。在内分泌科,患者接受了全面的检查,以评估甲状腺的状况和功能,并确定可能的并发症。
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引用次数: 0
Association of thyroidstimulating hormone, prolactin and leptin with metabolic status in young women 25-44 years old in Western Siberia 西西伯利亚地区25-44岁年轻女性促甲状腺激素、催乳素和瘦素与代谢状况的关系
Pub Date : 2023-04-13 DOI: 10.14341/ket12725
S. Mustafina, V. I. Alferova, S. M. Voevoda, D. Denisova, L. Scherbakova, E. Stakhneva, O. Rymar
AIM: To study anthropometric, biochemical and hormonal characteristics of women aged 25-44 with different levels of thyroid- stimulating hormone, prolactin and leptin.MATERIALS AND METHODS: From a representative sample of the young population of the Oktyabrsky district of Novosibirsk aged 25-44 years (840 women), a group of women (n=655) was selected to study cardiometabolic and hormonal parameters. The design of the study was a cross-sectional, observational, single-centre study. All participants underwent determination of anthropometric parameters (weight, measurement of waist circumference (WC) and hips (HC), calculation of BMI), systolic and diastolic blood pressure (SBP, DBP), biochemical parameters (total cholesterol (TC), high-density lipoprotein cholesterol ( HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), fasting plasma glucose (FPG), creatinine, calculation of glomerular filtration rate (GFR).Statistical processing was carried out using the SPSS-13 package.RESULTS: The study included 655 women, mean age 36.3±5.4 years, mean BMI 25.0±5.7 kg/m2. Young women showed direct associations of TSH with HC (r=0.115, p<0.05), TG (r=0.145, p<0.010) and inverse association with GFR (r=-0.129, p<0.05). PRL is inversely associated with HC (r=-0.109, p<0.05). Of all the studied hormones, leptin is most associated with anthropometric and biochemical parameters in young women. Thus, leptin is directly associated with WC (r=0.562, p<0.0001), HC (r=0.589, p<0.0001), WC/HC index (r=0.309, p<0.0001), BMI ( r=0.582, p<0.0001), as well as levels of SBP (r=0.293, p<0.0001), DBP (r=0.274, p<0.0001), TC (r=0.123, p=0.018), TG (r=0.234, p<0.0001), FPG (r=0.150, p=0.004), inversely related to HDL-C (r=-0.225, p<0.0001).CONCLUSION: The metabolic status of women aged 25-44 is associated with the level of TSH, leptin. It is advisable to determine TSH, leptin in young women with abdominal obesity for the purpose of dynamic monitoring and correction.
目的:研究25 ~ 44岁不同促甲状腺激素、催乳素、瘦素水平女性的人体测量学、生化及激素特征。材料与方法:从新西伯利亚奥克佳布尔斯基地区25-44岁年轻人口的代表性样本(840名女性)中,选择一组女性(n=655)来研究心脏代谢和激素参数。本研究设计为横断面、观察性、单中心研究。所有参与者都进行了人体测量参数(体重、腰围(WC)和臀围(HC)测量、BMI计算)、收缩压和舒张压(SBP、DBP)、生化参数(总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、空腹血糖(FPG)、肌酐、肾小球滤过率(GFR)计算。采用SPSS-13软件包进行统计处理。结果:纳入655名女性,平均年龄36.3±5.4岁,平均BMI 25.0±5.7 kg/m2。年轻女性TSH与HC (r=0.115, p<0.05)、TG (r=0.145, p<0.010)、GFR呈负相关(r=-0.129, p<0.05)。PRL与HC呈负相关(r=-0.109, p<0.05)。在所有研究的激素中,瘦素与年轻女性的人体测量和生化参数关系最为密切。因此,瘦素与WC (r=0.562, p<0.0001)、HC (r=0.589, p<0.0001)、WC/HC指数(r=0.309, p<0.0001)、BMI (r= 0.582, p<0.0001)以及SBP (r=0.293, p<0.0001)、DBP (r=0.274, p<0.0001)、TC (r=0.123, p=0.018)、TG (r=0.234, p<0.0001)、FPG (r=0.150, p=0.004)水平直接相关,与HDL-C (r=-0.225, p<0.0001)呈负相关。结论:25-44岁女性代谢状况与TSH、瘦素水平相关。年轻女性腹部肥胖,建议测定TSH、瘦素,以便动态监测和纠正。
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引用次数: 0
Low-iodine diet before radioactive iodine therapy - to prescribe or not to prescribe 放射性碘治疗前的低碘饮食——要开还是不要开
Pub Date : 2023-04-12 DOI: 10.14341/ket12746
A. R. Guselnikova, M. Korchagina, M. S. Sheremeta
Iodine is the most important trace element in the human body. Its main function is to participate in the synthesis of thyroid hormones, thyroxine (T4) and triiodothyronine (T3). The main source of iodine for humans is food rich in this trace element. The iodine content in foods varies greatly. The main sources of iodine are seafood, iodized salt, seaweed, as well as dairy products and egg yolks. In addition, iodine is found in a number of drugs for external and internal use, dietary supplements, and in iodinated contrast agents.Low-iodine diet (less than 50 μg per day) is prescribed before radioactive iodine therapy (RAIT) for thyroid diseases, namely hyperthyroidism and differentiated thyroid cancer. Currently, there is no consensus on the clinical benefits of such a diet, especially in countries with iodine deficiency, such as Russia.The aim of this review is to assess the need for a low-iodine diet and its optimal duration, as well as to determine the clinical characteristics affecting the outcome of RAIT, based on data from recent studies.
碘是人体中最重要的微量元素。其主要功能是参与甲状腺激素、甲状腺素(T4)和三碘甲状腺原氨酸(T3)的合成。人类碘的主要来源是富含这种微量元素的食物。食物中的碘含量差别很大。碘的主要来源是海鲜、加碘盐、海藻以及乳制品和蛋黄。此外,许多外用和内用药物、膳食补充剂和碘造影剂中都含有碘。甲状腺疾病,即甲状腺功能亢进和分化型甲状腺癌,在放射性碘治疗(RAIT)之前,应先开具低碘饮食(每天低于50 μg)。目前,对于这种饮食的临床益处还没有达成共识,特别是在俄罗斯等缺碘国家。本综述的目的是根据最近的研究数据,评估低碘饮食的必要性及其最佳持续时间,并确定影响RAIT结果的临床特征。
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引用次数: 0
期刊
Clinical and experimental thyroidology
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