Usefulness of a Memory Complaint Questionnaire for Predicting Amyloid PET Positivity in Community-Dwelling Older Adults

Abstract

Objective: This study aimed to assess the usefulness of a memory complaint questionnaire for predicting amyloid PET positivity in community-dwelling older adults. Methods: We recruited community-dwelling older adults without history of dementia who wished to participate in the study based on voluntary consent. We performed the Seoul Neuropsychological Screening Battery-Core (SNSB-C), Memory Age-associated Complaint Questionnaire (MACQ), Apolipoprotein E (ApoE) genotyping, and amyloid PET. According to the result of the SNSB-C, participants with objective cognitive impairment were excluded, and finally 124 participants were included in this study. We used receiver operating characteristic (ROC) curve and calculated area under the ROC curve (AUC) to evaluate usefulness of the MACQ compared to the result of ApoE genotyping for predicting amyloid PET positivity in cognitively unimpaired community-dwelling older adults. Results: The mean age of the study participants was 73.3 years, and 69.4% were female. ROC curve with MACQ score and with ApoE4 carrier was created and AUC of each model was calculated. AUC value was 0.660 for MACQ score, and 0.695 for ApoE4 carrier. There was no statistically significant difference in AUC value (p=0.494). Conclusion: In community-dwelling older adults without objective cognitive decline, the memory complaint questionnaire― MACQ showed no significant difference with ApoE4 carrier for predicting amyloid PET positivity.