Chemical composition and anti-inflammatory effect of Phellodendron amurense Rupr. stem bark extract

IF 1.4 4区生物学 Q3 PLANT SCIENCES Notulae Botanicae Horti Agrobotanici Cluj-napoca Pub Date : 2023-09-11 DOI:10.15835/nbha51313306

Sabina-Emanuela ERHAN, Alina E. PÂRVU, Alexandra CIORÎȚĂ, Ayu A. PUTRI, Alexis J. VILLAGRANA MOLINA, Marcel PÂRVU, Augustin C. MOȚ

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Abstract

In many diseases inflammation and oxidative stress coexist and are therapeutic targets. Phellodendron amurense Rupr. has anti-inflammatory and antioxidant effects, but the mechanisms are not completely elucidated. Therefore, first P. amurense stem bark extract was analysed regarding chemical compounds such as total polyphenol content (TPC), polyphenols (gallic acid, 4-hydroxybenzoic acid, caffeic acid and ferulic acid) and alkaloids (berbamine, jatrorrhizine, palmatine, and berberine). Quantitative determination of alkaloids revealed that berberine had the highest concentration of 2.44±0.22 mg/g. In vitro antioxidant activity was significant. Then, thein vivo anti-inflammatory and antioxidative effects of P. amurense extract were studied before and after acute experimental rat inflammation induction in order to find some mechanisms of these effects. The P. amurense stem bark extract had a good anti-inflammatory activity by reducing nitric oxide, 3-nitrotyrosine and NF-kB, and an antioxidant activity by lowering oxidants and increasing antioxidants. This study provides scientific knowledge and could contribute to the development of novel drugs based on P. amurense stem bark extract for the treatment of inflammatory diseases and prevention of oxidative stress.

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黄柏的化学成分及抗炎作用。茎皮提取物

在许多疾病中，炎症和氧化应激共存，是治疗的靶点。黄柏具有抗炎、抗氧化作用，但机制尚未完全阐明。因此，首先分析了苦参茎皮提取物的化学成分，如总多酚含量(TPC)、多酚类物质(没食子酸、4-羟基苯甲酸、咖啡酸和阿魏酸)和生物碱(小檗碱、麻草酸、棕榈碱和小檗碱)。生物碱含量测定结果显示，小檗碱浓度最高，为2.44±0.22 mg/g。体外抗氧化活性显著。然后，在急性实验性大鼠炎症诱导前后，研究金盏花提取物的体内抗炎和抗氧化作用，探讨其作用机制。苦参茎皮提取物通过降低一氧化氮、3-硝基酪氨酸和NF-kB具有良好的抗炎活性，通过降低氧化剂和增加抗氧化剂具有良好的抗氧化活性。本研究提供了科学知识，有助于开发以金钱树茎皮提取物为基础的治疗炎症性疾病和预防氧化应激的新药。

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来源期刊

Notulae Botanicae Horti Agrobotanici Cluj-napoca PLANT SCIENCES-

CiteScore

2.70

自引率

0.00%

发文量

118

审稿时长

3 months

期刊介绍： Notulae Botanicae Horti Agrobotanici Cluj-Napoca is a peer-reviewed biannual journal aimed at disseminating significant research and original papers, critical reviews and short reviews. The subjects refer on plant biodiversity, genetics and plant breeding, development of new methodologies that can be of interest to a wide audience of plant scientists in all areas of plant biology, agriculture, horticulture and forestry. The journal encourages authors to frame their research questions and discuss their results in terms of the major questions of plant sciences, thereby maximizing the impact and value of their research, and thus in favor of spreading their studies outcome. The papers must be of potential interest to a significant number of scientists and, if specific to a local situation, must be relevant to a wide body of knowledge in life sciences. Articles should make a significant contribution to the advancement of knowledge or toward a better understanding of existing biological and agricultural concepts. An international Editorial Board advises the journal. The total content of the journal may be used for educational, non-profit purposes without regard to copyright. The distribution of the material is encouraged with the condition that the authors and the source (Notulae Botanicae Horti Agrobotanici Cluj-Napoca or JCR abbrev. title Not Bot Horti Agrobo) are mentioned.