Senolytic drugs: implications for clinical practice

Abstract

The aging mechanisms study is one of the most important aims in the field of geroscience and clinical medicine. There has been a wide range of fundamental research data accumulated on this matter. The processes associated with regeneration capability decrease, age-related decline of cell proliferation and resilience are highlighted in vitro studies, as well as on animal models, but their translation into clinical practice has not been carried out yet. Our aim was to study the most important mechanisms of aging and the ways of influencing on them with geroprotective technologies, such as senolytic medications. The relevance of this topic is confirmed by increasing number of launched clinical trials, but their results are often ambiguous and require further analysis and elimination of the identified difficulties and shortcomings. We have searched and analysed the literature over the past 10 years using Pubmed and Scopus, in order to find information about the main mechanisms of aging, and possible use of geroprotective medicatios in clinical practice.