Pub Date : 2023-12-18DOI: 10.37586/2949-4745-2-2023-102-107
K. Eruslanova, S. O. Zhikrivetskaya, Yulia V. Kotovskaya, O. N. Tkacheva
Aim. To evaluate the association between telomere length and frailty and individual geriatric syndromes in older adults. Materials and methods. The database of a hundred-year-old citizen of the city of Moscow was analyzed. The analysis was carried out using the data driven from the Comprehensive Geriatric Assessment (CGA), in particular, Age is not a Hindrance Scale, the Barthel index, Instrumental Activities of Daily Living (IADL), Mini Nutritional Assessment (MNA), Mini-Mental State Examination (MMSE), and Geriatric Depression Scale (GDS-15). DNA was isolated from frozen blood and a study of telomere length was performed. The comparison of telomere length in groups of patients with frailty and individual geriatric syndromes was carried out. Results. The study involved 60 people (98±1.8 years, 86.7% women). The analysis found no differences in telomere length in study participants with and without frailty, as well as in the analysis of individual geriatric syndromes. No correlation was found between telomere length and the results of comprehensive geriatric assessment scales. There was no difference in telomere length in patients who died within 3 years of follow-up and no. Conclusion. No relationship was found between telomere length and frailty. Thus, telomere length cannot be considered as a reliable biomarker of functional aging.
{"title":"Association between Telomere Length and Geriatric Status in Centenarians","authors":"K. Eruslanova, S. O. Zhikrivetskaya, Yulia V. Kotovskaya, O. N. Tkacheva","doi":"10.37586/2949-4745-2-2023-102-107","DOIUrl":"https://doi.org/10.37586/2949-4745-2-2023-102-107","url":null,"abstract":" Aim. To evaluate the association between telomere length and frailty and individual geriatric syndromes in older adults. Materials and methods. The database of a hundred-year-old citizen of the city of Moscow was analyzed. The analysis was carried out using the data driven from the Comprehensive Geriatric Assessment (CGA), in particular, Age is not a Hindrance Scale, the Barthel index, Instrumental Activities of Daily Living (IADL), Mini Nutritional Assessment (MNA), Mini-Mental State Examination (MMSE), and Geriatric Depression Scale (GDS-15). DNA was isolated from frozen blood and a study of telomere length was performed. The comparison of telomere length in groups of patients with frailty and individual geriatric syndromes was carried out. Results. The study involved 60 people (98±1.8 years, 86.7% women). The analysis found no differences in telomere length in study participants with and without frailty, as well as in the analysis of individual geriatric syndromes. No correlation was found between telomere length and the results of comprehensive geriatric assessment scales. There was no difference in telomere length in patients who died within 3 years of follow-up and no. Conclusion. No relationship was found between telomere length and frailty. Thus, telomere length cannot be considered as a reliable biomarker of functional aging.","PeriodicalId":489436,"journal":{"name":"Problems of Geroscience","volume":" 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138964354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.37586/2949-4745-1-2023-7-14
A. K. Ilyushchenko, L. V. Matchekhina, O. N. Tkacheva, A. V. Balashova, A. A. Melnitskaia, A. V. Churov, I. D. Strazhesko
The aging mechanisms study is one of the most important aims in the field of geroscience and clinical medicine. There has been a wide range of fundamental research data accumulated on this matter. The processes associated with regeneration capability decrease, age-related decline of cell proliferation and resilience are highlighted in vitro studies, as well as on animal models, but their translation into clinical practice has not been carried out yet. Our aim was to study the most important mechanisms of aging and the ways of influencing on them with geroprotective technologies, such as senolytic medications. The relevance of this topic is confirmed by increasing number of launched clinical trials, but their results are often ambiguous and require further analysis and elimination of the identified difficulties and shortcomings. We have searched and analysed the literature over the past 10 years using Pubmed and Scopus, in order to find information about the main mechanisms of aging, and possible use of geroprotective medicatios in clinical practice.
{"title":"Senolytic drugs: implications for clinical practice","authors":"A. K. Ilyushchenko, L. V. Matchekhina, O. N. Tkacheva, A. V. Balashova, A. A. Melnitskaia, A. V. Churov, I. D. Strazhesko","doi":"10.37586/2949-4745-1-2023-7-14","DOIUrl":"https://doi.org/10.37586/2949-4745-1-2023-7-14","url":null,"abstract":"The aging mechanisms study is one of the most important aims in the field of geroscience and clinical medicine. There has been a wide range of fundamental research data accumulated on this matter. The processes associated with regeneration capability decrease, age-related decline of cell proliferation and resilience are highlighted in vitro studies, as well as on animal models, but their translation into clinical practice has not been carried out yet. Our aim was to study the most important mechanisms of aging and the ways of influencing on them with geroprotective technologies, such as senolytic medications. The relevance of this topic is confirmed by increasing number of launched clinical trials, but their results are often ambiguous and require further analysis and elimination of the identified difficulties and shortcomings. We have searched and analysed the literature over the past 10 years using Pubmed and Scopus, in order to find information about the main mechanisms of aging, and possible use of geroprotective medicatios in clinical practice.","PeriodicalId":489436,"journal":{"name":"Problems of Geroscience","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136026256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.37586/2949-4745-1-2023-31-38
A. A. Akopyan, I. D. Strazhesko, A. A. Moskalev, I. A. Orlova
Background. Biological age is a better predictor of morbidity and mortality associated with chronic age-related diseases than chronological age. The estimated difference between biological and chronological age can reveal an individual’s rate of aging.Aim. The aim of this study was to assess the association of cardiovascular risk factors with the rate of aging in people without cardiovascular diseases. Materials and methods. We calculated biological artery age and found associations of “old” arteries and rate of aging with risk factors of cardiovascular diseases in 143 adults without cardiovascular diseases. The data were analyzed by their categorization into 3 tertiles using regression methods.Results. “Old” arteries were associated with chronological age (p < 0,001; ОR = 0,55; 95% CI: 0,43 — 0,71) and hypertension (p = 0,002; ОR = 6,04; 95% CI: 1,98 — 18,42) in general group, age (p < 0,001; ОR = 0,45; 95% CI: 0,30 — 0,68), hypertension (p = 0,004; ОR = 12,79; 95% CI: 2,25 — 72,55) and family history of oncology (p = 0,036; ОR = 0,14; 95% CI: 0,02 — 0,88) in women subgroup and age (p = 0,001; ОR = 0,45; 95% CI: 0,28 — 0,76) and 3rd tertile of glycated hemoglobin (p = 0,041; ОR = 65,05; 95% CI: 1,19 — 3548,29) in men subgroup. Difference between biological and chronological age in a group of “old” arteries was associated with chronological age (p = 0,001; β = -1,24; 95% CI: -1,95 — -0,53) and with chronological age (p < 0,001; β = 1,71; 95% CI: 1,06 — 2,36) and 3rd tertile of glycated hemoglobin (p = 0,009; β = -4,78; 95% CI: -8,32 — -1,24) in group of “young” arteries.Conclusion. This study demonstrates that accelerated arterial aging is associated with hypertension and high levels of glycated haemoglobin.
{"title":"The rate of aging and its association with risk factors of cardiovascular diseases","authors":"A. A. Akopyan, I. D. Strazhesko, A. A. Moskalev, I. A. Orlova","doi":"10.37586/2949-4745-1-2023-31-38","DOIUrl":"https://doi.org/10.37586/2949-4745-1-2023-31-38","url":null,"abstract":"Background. Biological age is a better predictor of morbidity and mortality associated with chronic age-related diseases than chronological age. The estimated difference between biological and chronological age can reveal an individual’s rate of aging.Aim. The aim of this study was to assess the association of cardiovascular risk factors with the rate of aging in people without cardiovascular diseases. Materials and methods. We calculated biological artery age and found associations of “old” arteries and rate of aging with risk factors of cardiovascular diseases in 143 adults without cardiovascular diseases. The data were analyzed by their categorization into 3 tertiles using regression methods.Results. “Old” arteries were associated with chronological age (p < 0,001; ОR = 0,55; 95% CI: 0,43 — 0,71) and hypertension (p = 0,002; ОR = 6,04; 95% CI: 1,98 — 18,42) in general group, age (p < 0,001; ОR = 0,45; 95% CI: 0,30 — 0,68), hypertension (p = 0,004; ОR = 12,79; 95% CI: 2,25 — 72,55) and family history of oncology (p = 0,036; ОR = 0,14; 95% CI: 0,02 — 0,88) in women subgroup and age (p = 0,001; ОR = 0,45; 95% CI: 0,28 — 0,76) and 3rd tertile of glycated hemoglobin (p = 0,041; ОR = 65,05; 95% CI: 1,19 — 3548,29) in men subgroup. Difference between biological and chronological age in a group of “old” arteries was associated with chronological age (p = 0,001; β = -1,24; 95% CI: -1,95 — -0,53) and with chronological age (p < 0,001; β = 1,71; 95% CI: 1,06 — 2,36) and 3rd tertile of glycated hemoglobin (p = 0,009; β = -4,78; 95% CI: -8,32 — -1,24) in group of “young” arteries.Conclusion. This study demonstrates that accelerated arterial aging is associated with hypertension and high levels of glycated haemoglobin.","PeriodicalId":489436,"journal":{"name":"Problems of Geroscience","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136026258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.37586/2949-4745-1-2023-39-50
L. V. Maytesyan, I. R. Tsoy, O. N. Tkacheva, I. D. Strazhesko
Currently, an increasing number of patients continue to experience long COVID-19 symptoms after initially contracting the SARS-CoV-2 virus. In this regard, it is important to identify the factors associated with the development of post-COVID syndrome and possible ways to influence them.We examined 100 patients aged 26–80 years. The mean age of all participants was 56 ± 12 years. Patients who had severe coronavirus pneumonia 3 months prior to enrollment experienced mainly fatigue, shortness of breath, sleep disorder, hair loss, joint pain, and headache.In this article, we described the most possible causes and risk factors for the development of post-COVID syndrome.
{"title":"The Relationship between Long COVID Symptoms and Clinical and Laboratory Characteristics","authors":"L. V. Maytesyan, I. R. Tsoy, O. N. Tkacheva, I. D. Strazhesko","doi":"10.37586/2949-4745-1-2023-39-50","DOIUrl":"https://doi.org/10.37586/2949-4745-1-2023-39-50","url":null,"abstract":"Currently, an increasing number of patients continue to experience long COVID-19 symptoms after initially contracting the SARS-CoV-2 virus. In this regard, it is important to identify the factors associated with the development of post-COVID syndrome and possible ways to influence them.We examined 100 patients aged 26–80 years. The mean age of all participants was 56 ± 12 years. Patients who had severe coronavirus pneumonia 3 months prior to enrollment experienced mainly fatigue, shortness of breath, sleep disorder, hair loss, joint pain, and headache.In this article, we described the most possible causes and risk factors for the development of post-COVID syndrome.","PeriodicalId":489436,"journal":{"name":"Problems of Geroscience","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136026259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.37586/2949-4745-1-2023-25-30
M. A. Chelombitko, G. V. Morgunova, N. Y. Strochkova, K. G. Lyamzaev
Background. The field of gerontology is actively seeking senolytics and senomorphs that can influence the quantity and activity of senescent cells in the body. Previous studies have demonstrated the geroprotective properties of mitochondrial- directed compounds based on plastoquinone and berberine in various in vitro and in vivo models. Thus, it is plausible that SkQBerb, a mitochondrialtargeted compound combining berberine and plastoquinone, may exhibit higher geroprotective potential compared to previously studied compounds.Objective. The aim of this study is to investigate the geroprotective activity of SkQBerb in a chronological aging model using MB135 myoblasts.Materials and Methods. The effect of SkQBerb on various aging characteristics of human MB135 myoblasts was assessed. Histochemical staining for β-galactosidase was performed using a commercially available kit. The levels of proinflammatory cytokines IL-6 and IL-8 were determined using pre-made immunoassay kits. Additionally, Western blotting was employed to evaluate the levels of p21, pRb (Ser807/811), and LC3B proteins.Results. Analysis of the results revealed that SkQBerb, at concentrations ranging from 20–100 nM, effectively suppressed the accumulation of senescent cells in MB135 cells subjected to chronological aging. Furthermore, it significantly reduced the levels of IL-6 and IL-8, key factors associated with the secretory phenotype.Conclusion. The findings of this study suggest a potential geroprotective and senomorphic effect of SkQBerb. These results open up possibilities for utilizing this mitochondrial-targeted compound as a geroprotector in future applications.
{"title":"Geroprotective effect of the mitochondrial-targeted antioxidant SkQBerb in a model of chronological aging of human MB135 myoblasts","authors":"M. A. Chelombitko, G. V. Morgunova, N. Y. Strochkova, K. G. Lyamzaev","doi":"10.37586/2949-4745-1-2023-25-30","DOIUrl":"https://doi.org/10.37586/2949-4745-1-2023-25-30","url":null,"abstract":"Background. The field of gerontology is actively seeking senolytics and senomorphs that can influence the quantity and activity of senescent cells in the body. Previous studies have demonstrated the geroprotective properties of mitochondrial- directed compounds based on plastoquinone and berberine in various in vitro and in vivo models. Thus, it is plausible that SkQBerb, a mitochondrialtargeted compound combining berberine and plastoquinone, may exhibit higher geroprotective potential compared to previously studied compounds.Objective. The aim of this study is to investigate the geroprotective activity of SkQBerb in a chronological aging model using MB135 myoblasts.Materials and Methods. The effect of SkQBerb on various aging characteristics of human MB135 myoblasts was assessed. Histochemical staining for β-galactosidase was performed using a commercially available kit. The levels of proinflammatory cytokines IL-6 and IL-8 were determined using pre-made immunoassay kits. Additionally, Western blotting was employed to evaluate the levels of p21, pRb (Ser807/811), and LC3B proteins.Results. Analysis of the results revealed that SkQBerb, at concentrations ranging from 20–100 nM, effectively suppressed the accumulation of senescent cells in MB135 cells subjected to chronological aging. Furthermore, it significantly reduced the levels of IL-6 and IL-8, key factors associated with the secretory phenotype.Conclusion. The findings of this study suggest a potential geroprotective and senomorphic effect of SkQBerb. These results open up possibilities for utilizing this mitochondrial-targeted compound as a geroprotector in future applications.","PeriodicalId":489436,"journal":{"name":"Problems of Geroscience","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136026260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.37586/2949-4745-1-2023-51-57
M. S. Arbatskiy
Background. One of the main concerns posed by implementing new biomedical technologies is the lack of a pharmacoeconomic justification for the economic effect or the burden of certain nosologies on the state budget. To date, the medical literature on age-related diseases focuses on diagnosis, pathogenesis, new methods of treatment and the results of prescribed treatment. However, assessing the economic burden of these diseases is equally important. Only for selected diseases, regular publications on the calculation of the economic effect and economic burden of diseases can be found. For less common diseases, there are single publications, the information from which is no longer relevant and requires regular updating and maintenance.Aim. To conduct an indicative assessment of the economic burden for the most common age-related diseases.Materials and methods. When preparing the publication, foreign and domestic sources containing economic information about the most common age-associated diseases were used.Annual reports of biopharmaceutical companies producing drugs for the treatment of age-related diseases were used to obtain an understanding of current developments in the treatment of these diseases. Additionally, data from Rosreestr (Russian Federal Service for State Registration, Cadastre and Cartography) were used for certain diseases.Results. According to the analyzed information, it has been found that age-related diseases are a significant economic burden for the healthcare system of the state. However, not all specialized medical organizations assess the economic burden associated with such diseases.Conclusion. As a result of analyzing the economic burden of the most common age-related diseases, the conclusion can be drawn that regular assessment of the economic burden for Alzheimer's disease, diabetes, chronic obstructive pulmonary disease, depression, atherosclerosis and osteoporosis is necessary
{"title":"Economic burden of some age-related diseases","authors":"M. S. Arbatskiy","doi":"10.37586/2949-4745-1-2023-51-57","DOIUrl":"https://doi.org/10.37586/2949-4745-1-2023-51-57","url":null,"abstract":"Background. One of the main concerns posed by implementing new biomedical technologies is the lack of a pharmacoeconomic justification for the economic effect or the burden of certain nosologies on the state budget. To date, the medical literature on age-related diseases focuses on diagnosis, pathogenesis, new methods of treatment and the results of prescribed treatment. However, assessing the economic burden of these diseases is equally important. Only for selected diseases, regular publications on the calculation of the economic effect and economic burden of diseases can be found. For less common diseases, there are single publications, the information from which is no longer relevant and requires regular updating and maintenance.Aim. To conduct an indicative assessment of the economic burden for the most common age-related diseases.Materials and methods. When preparing the publication, foreign and domestic sources containing economic information about the most common age-associated diseases were used.Annual reports of biopharmaceutical companies producing drugs for the treatment of age-related diseases were used to obtain an understanding of current developments in the treatment of these diseases. Additionally, data from Rosreestr (Russian Federal Service for State Registration, Cadastre and Cartography) were used for certain diseases.Results. According to the analyzed information, it has been found that age-related diseases are a significant economic burden for the healthcare system of the state. However, not all specialized medical organizations assess the economic burden associated with such diseases.Conclusion. As a result of analyzing the economic burden of the most common age-related diseases, the conclusion can be drawn that regular assessment of the economic burden for Alzheimer's disease, diabetes, chronic obstructive pulmonary disease, depression, atherosclerosis and osteoporosis is necessary","PeriodicalId":489436,"journal":{"name":"Problems of Geroscience","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136026257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.37586/2949-4745-1-2023-15-24
V. S. Pykhtina
Frailty is the main geriatric syndrome, which is closely associated with agerelated diseases and aging in general. Being considered the main pathogenetic mechanism of aging, low-grade chronic inflammation potentially contributes to increased degradation of the essential amino acid tryptophan through the kynurenine pathway. Active metabolites of the kynurenine pathway, when accumulated, realize their immunomodulatory, pro-inflammatory and cytotoxic properties, thereby supporting and enhancing the aging process. Over the past decade, data have been collected on the role of an unbalanced kynurenine pathway in the pathogenesis of frailty and age-related diseases. This review summarizes clinical and experimental data on the importance of kynurenine pathway analysis as a valuable tool for risk stratification and prognosis of frailty and age-related diseases.
{"title":"The role of kynurenine pathway metabolites in the development of frailty in older adults","authors":"V. S. Pykhtina","doi":"10.37586/2949-4745-1-2023-15-24","DOIUrl":"https://doi.org/10.37586/2949-4745-1-2023-15-24","url":null,"abstract":"Frailty is the main geriatric syndrome, which is closely associated with agerelated diseases and aging in general. Being considered the main pathogenetic mechanism of aging, low-grade chronic inflammation potentially contributes to increased degradation of the essential amino acid tryptophan through the kynurenine pathway. Active metabolites of the kynurenine pathway, when accumulated, realize their immunomodulatory, pro-inflammatory and cytotoxic properties, thereby supporting and enhancing the aging process. Over the past decade, data have been collected on the role of an unbalanced kynurenine pathway in the pathogenesis of frailty and age-related diseases. This review summarizes clinical and experimental data on the importance of kynurenine pathway analysis as a valuable tool for risk stratification and prognosis of frailty and age-related diseases.","PeriodicalId":489436,"journal":{"name":"Problems of Geroscience","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136026261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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