Green Extraction, Phytochemical Profiling, and Biological Evaluation of Dysphania ambrosioides : An In Silico and In Vitro Medicinal Investigation

IF 1.2 Q4 PHARMACOLOGY & PHARMACY Journal of Herbs, Spices and Medicinal Plants Pub Date : 2023-10-16 DOI:10.1080/10496475.2023.2267467

Namuna Paudel, Mansi Rai, Santosh Adhikari, Arjun Thapa, Samjhana Bharati, Binita Maharjan, Ram Lal Swagat Shrestha, Kranti Rav, Ajay Vikram Singh

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Abstract

ABSTRACTParasitic and microbial infections present substantial health risks, requiring effective treatments amidst growing antibiotic resistance. This study delves into Dysphania ambrosioides medicinal properties, utilizing hydro distillation and ultrasonic methods for extraction, followed by GC-MS analysis. Assessments revealed potent anti-diabetic effects in the methanol extract, significant antioxidant activity in the DCM extract and oil, and resistance against Escherichia coli. This research underscores the potential of local flora for novel treatments, particularly in underdeveloped regions. It emphasizes the value of plant screening in bioprospecting efforts, suggesting further investigations into specific bioactive compounds for pharmaceutical applications.KEYWORDS: Dysphania ambrosioidesTFCphytochemical screeningGC-MSantibacterialTPCantioxidant AcknowledgmentsFinancial assistance from the BfR (SFP 1322-807) is thankfully acknowledged.Disclosure StatementNo potential conflict of interest was reported by the author(s).Data Availability StatementData are available on request from the authors.Supplementary MaterialSupplemental data for this article can be accessed online at https://doi.org/10.1080/10496475.2023.2267467

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绿色提取，植物化学分析和生物评价:一个硅和体外药物研究

摘要寄生虫和微生物感染存在巨大的健康风险，在抗生素耐药性不断增强的情况下，需要有效的治疗。本研究采用水力蒸馏法和超声波提取法，结合气相色谱-质谱联用分析方法，研究了凤仙花的药用特性。评估显示甲醇提取物具有有效的抗糖尿病作用，DCM提取物和油具有显著的抗氧化活性，并且对大肠杆菌具有抗性。这项研究强调了当地植物群对新治疗方法的潜力，特别是在欠发达地区。强调了植物筛选在生物勘探工作中的价值，建议进一步研究具有特定生物活性的化合物。【关键词】氨溴sioides;植物化学筛选;gc - msantimicrobial;;披露声明作者未报告潜在的利益冲突。数据可用性声明数据可根据作者的要求提供。补充材料本文的补充数据可在https://doi.org/10.1080/10496475.2023.2267467上在线获取

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

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0.00%

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期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.