Pub Date : 2023-10-21DOI: 10.1080/10496475.2023.2271416
Sadik Aref
ABSTRACTThis study explored the potential of Andrographis paniculata in regulating redox imbalance using planaria as a model organism. Decapitated planaria were regenerated in water, A. paniculata extract, hydrogen peroxide, and a combination of hydrogen peroxide and A. paniculata. The growth was 26% higher, locomotion 15% higher, and protein 35% higher in A. paniculata group. The stressed group had 33% higher growth, 17% higher locomotion, and 36% higher protein when treated with A. paniculata. In conclusion, A. paniculata accelerated the regeneration and minimized the stress induced by hydrogen peroxide and hence can be a promising option for the prevention of neurodegenerative diseases.KEYWORDS: Andrographolideplanariaredox Disclosure statementNo potential conflict of interest was reported by the author(s).
{"title":"Effect of <i>Andrographis paniculata</i> Extracts on Regeneration and Prevention of Oxidative Stress Damage in Planaria","authors":"Sadik Aref","doi":"10.1080/10496475.2023.2271416","DOIUrl":"https://doi.org/10.1080/10496475.2023.2271416","url":null,"abstract":"ABSTRACTThis study explored the potential of Andrographis paniculata in regulating redox imbalance using planaria as a model organism. Decapitated planaria were regenerated in water, A. paniculata extract, hydrogen peroxide, and a combination of hydrogen peroxide and A. paniculata. The growth was 26% higher, locomotion 15% higher, and protein 35% higher in A. paniculata group. The stressed group had 33% higher growth, 17% higher locomotion, and 36% higher protein when treated with A. paniculata. In conclusion, A. paniculata accelerated the regeneration and minimized the stress induced by hydrogen peroxide and hence can be a promising option for the prevention of neurodegenerative diseases.KEYWORDS: Andrographolideplanariaredox Disclosure statementNo potential conflict of interest was reported by the author(s).","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135512976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-17DOI: 10.1080/10496475.2023.2269888
Ayoub Amssayef, Bouchra Soulaimani, Adil Qabouche, Abdelaziz Abbad, Mohamed Eddouks
ABSTRACTThe impact of Origanum compactum essential oil (EO) at 80 mg kg−1 on Triton WR-1339-induced hyperlipidemia in rats was investigated.The EO’s phytochemical composition revealed the predominance of carvacrol (35.71%), p-cymene (13.74%), and carvacrol methyl ether (11.71%). Triton WR-1339 led to elevations in total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), as well asatherogenic indices encompassing the atherogenic coefficient (AC), Castelli’s risk index I (CRI-I), and Castelli’s risk index II (CRI-II). Conversely, pretreatment with O. Compactum EO for sevendays exerted a preventive effect against the increase of TC, TGs, LDL-C, VLDL-C, AC, CRI-I.KEYWORDS: Antihyperlipidemic effectmedicinal plantstoxicityLD50 Disclosure statementNo potential conflict of interest was reported by the author(s).Ethics ApprovalAll experiments were performed according to the local ethical committee, Faculty of Science and Techniques Errachidia, Morocco, number FSTE/2015.Abbreviations AC=Atherogenic coefficientCRI=Castelli’s risk indexEO=Essential oilHDL-C=High-density lipoprotein cholesterolHMG-CoA reductase=Hydroxymethyl-glutaryl coenzyme A reductaseLDL-C=Low-density lipoprotein cholesterolTC=Total cholesterolTGs=TriglyceridesVLDL-C=Very-low-density lipoprotein cholesterolAdditional informationFundingThis work was supported by the CNRST under grant N° PPR/2015/35.
摘要本文研究了80 mg kg -1莪术精油对Triton wr -1339诱导的大鼠高脂血症的影响。植物化学成分以香芹酚(35.71%)、对花香烃(13.74%)和香芹酚甲醚(11.71%)为主。Triton WR-1339导致总胆固醇(TC)、甘油三酯(tg)、低密度脂蛋白胆固醇(LDL-C)、极低密度脂蛋白胆固醇(VLDL-C)升高，以及包括致动脉粥样硬化系数(AC)、Castelli风险指数I (CRI-I)和Castelli风险指数II (CRI-II)在内的致动脉粥样硬化指标升高。相反，用O. Compactum EO预处理7 d对TC、tg、LDL-C、VLDL-C、AC、cri的升高有预防作用。关键词:降血脂作用;药用植物;毒性;所有实验均按照摩洛哥埃拉奇迪亚科学与技术学院当地伦理委员会的规定进行，编号FSTE/2015。缩写AC=动脉粥样硬化系数cri =Castelli 's风险指数eo =香精油hdl - c =高密度脂蛋白胆固醇hmg - coa还原酶=羟甲基-戊二酰辅酶A还原酶eldl - c =低密度脂蛋白胆固醇tc =总胆固醇tg =甘油三酯vldl - c =极低密度脂蛋白胆固醇经费来源本研究由CNRST资助，项目编号PPR/2015/35。
{"title":"<i>Origanum Compactum</i> Essential Oil Ameliorates Triton WR-1339-Induced Hyperlipidemia in Rats: Chemical Composition and Acute Toxicity","authors":"Ayoub Amssayef, Bouchra Soulaimani, Adil Qabouche, Abdelaziz Abbad, Mohamed Eddouks","doi":"10.1080/10496475.2023.2269888","DOIUrl":"https://doi.org/10.1080/10496475.2023.2269888","url":null,"abstract":"ABSTRACTThe impact of Origanum compactum essential oil (EO) at 80 mg kg−1 on Triton WR-1339-induced hyperlipidemia in rats was investigated.The EO’s phytochemical composition revealed the predominance of carvacrol (35.71%), p-cymene (13.74%), and carvacrol methyl ether (11.71%). Triton WR-1339 led to elevations in total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), as well asatherogenic indices encompassing the atherogenic coefficient (AC), Castelli’s risk index I (CRI-I), and Castelli’s risk index II (CRI-II). Conversely, pretreatment with O. Compactum EO for sevendays exerted a preventive effect against the increase of TC, TGs, LDL-C, VLDL-C, AC, CRI-I.KEYWORDS: Antihyperlipidemic effectmedicinal plantstoxicityLD50 Disclosure statementNo potential conflict of interest was reported by the author(s).Ethics ApprovalAll experiments were performed according to the local ethical committee, Faculty of Science and Techniques Errachidia, Morocco, number FSTE/2015.Abbreviations AC=Atherogenic coefficientCRI=Castelli’s risk indexEO=Essential oilHDL-C=High-density lipoprotein cholesterolHMG-CoA reductase=Hydroxymethyl-glutaryl coenzyme A reductaseLDL-C=Low-density lipoprotein cholesterolTC=Total cholesterolTGs=TriglyceridesVLDL-C=Very-low-density lipoprotein cholesterolAdditional informationFundingThis work was supported by the CNRST under grant N° PPR/2015/35.","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136032872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-17DOI: 10.1080/10496475.2023.2269372
Addisu Assefa, Helmut Kloos, Assegid Zewdu
ABSTRACTAntimicrobial activity of solvent extracts of Brassica nigra, Trigonella foenum-graecum, and Schinus molle were investigated against six bacterial pathogens. The highest zone of inhibition (ZOI) were noted for methanol extract of B. nigra against S. boydii. The highest activity index (AI) was noted in methanol extract of B. nigra against S. boydi (AI = 0.86) using ciprofloxacin as positive control but AI ≥ 1.0 in some extracts while using gentamicin as positive control. The minimum inhibitory concentration (MIC) of the extracts ranged from 6.25 mg mL−1 to 100 mg mL−1. The antibacterial activity of the extracts was B. nigra > T. foenum-graecum > S. molle.KEYWORDS: Antibacterial activityactivity indextest bacterial pathogens AcknowledgmentsWe thank the Department of Biology, the College of Natural and Computational Sciences, and the School of Graduate Studies of Madda Walabu University for their administrative and material support. We are also highly grateful to the Ethiopian Public Health Institute for providing us the bacterial test pathogens used in this study. The National Herbarium in Addis Ababa (Ethiopia) is also acknowledged for its cooperation in the identification of plant samples used in this study. We also thank Ann Byers for editing the manuscript at short notice.Disclosure statementNo potential conflict of interest was reported by the author(s).Data availability statementAll relevant data are within the manuscript and its supporting information files.Supplementary materialSupplemental data for this article can be accessed online at https://doi.org/10.1080/10496475.2023.2269372Additional informationFundingThe authors received no specific funding from any sources.
{"title":"In vitro antimicrobial activity of <i>Brassica nigra</i> , <i>Trigonella foenum-graecum</i> , and <i>Schinus molle</i> in Ethiopia against selected human bacterial pathogens","authors":"Addisu Assefa, Helmut Kloos, Assegid Zewdu","doi":"10.1080/10496475.2023.2269372","DOIUrl":"https://doi.org/10.1080/10496475.2023.2269372","url":null,"abstract":"ABSTRACTAntimicrobial activity of solvent extracts of Brassica nigra, Trigonella foenum-graecum, and Schinus molle were investigated against six bacterial pathogens. The highest zone of inhibition (ZOI) were noted for methanol extract of B. nigra against S. boydii. The highest activity index (AI) was noted in methanol extract of B. nigra against S. boydi (AI = 0.86) using ciprofloxacin as positive control but AI ≥ 1.0 in some extracts while using gentamicin as positive control. The minimum inhibitory concentration (MIC) of the extracts ranged from 6.25 mg mL−1 to 100 mg mL−1. The antibacterial activity of the extracts was B. nigra > T. foenum-graecum > S. molle.KEYWORDS: Antibacterial activityactivity indextest bacterial pathogens AcknowledgmentsWe thank the Department of Biology, the College of Natural and Computational Sciences, and the School of Graduate Studies of Madda Walabu University for their administrative and material support. We are also highly grateful to the Ethiopian Public Health Institute for providing us the bacterial test pathogens used in this study. The National Herbarium in Addis Ababa (Ethiopia) is also acknowledged for its cooperation in the identification of plant samples used in this study. We also thank Ann Byers for editing the manuscript at short notice.Disclosure statementNo potential conflict of interest was reported by the author(s).Data availability statementAll relevant data are within the manuscript and its supporting information files.Supplementary materialSupplemental data for this article can be accessed online at https://doi.org/10.1080/10496475.2023.2269372Additional informationFundingThe authors received no specific funding from any sources.","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135993844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACTParasitic and microbial infections present substantial health risks, requiring effective treatments amidst growing antibiotic resistance. This study delves into Dysphania ambrosioides medicinal properties, utilizing hydro distillation and ultrasonic methods for extraction, followed by GC-MS analysis. Assessments revealed potent anti-diabetic effects in the methanol extract, significant antioxidant activity in the DCM extract and oil, and resistance against Escherichia coli. This research underscores the potential of local flora for novel treatments, particularly in underdeveloped regions. It emphasizes the value of plant screening in bioprospecting efforts, suggesting further investigations into specific bioactive compounds for pharmaceutical applications.KEYWORDS: Dysphania ambrosioidesTFCphytochemical screeningGC-MSantibacterialTPCantioxidant AcknowledgmentsFinancial assistance from the BfR (SFP 1322-807) is thankfully acknowledged.Disclosure StatementNo potential conflict of interest was reported by the author(s).Data Availability StatementData are available on request from the authors.Supplementary MaterialSupplemental data for this article can be accessed online at https://doi.org/10.1080/10496475.2023.2267467
{"title":"Green Extraction, Phytochemical Profiling, and Biological Evaluation of <i>Dysphania ambrosioides</i> : An <i>In Silico</i> and <i>In Vitro</i> Medicinal Investigation","authors":"Namuna Paudel, Mansi Rai, Santosh Adhikari, Arjun Thapa, Samjhana Bharati, Binita Maharjan, Ram Lal Swagat Shrestha, Kranti Rav, Ajay Vikram Singh","doi":"10.1080/10496475.2023.2267467","DOIUrl":"https://doi.org/10.1080/10496475.2023.2267467","url":null,"abstract":"ABSTRACTParasitic and microbial infections present substantial health risks, requiring effective treatments amidst growing antibiotic resistance. This study delves into Dysphania ambrosioides medicinal properties, utilizing hydro distillation and ultrasonic methods for extraction, followed by GC-MS analysis. Assessments revealed potent anti-diabetic effects in the methanol extract, significant antioxidant activity in the DCM extract and oil, and resistance against Escherichia coli. This research underscores the potential of local flora for novel treatments, particularly in underdeveloped regions. It emphasizes the value of plant screening in bioprospecting efforts, suggesting further investigations into specific bioactive compounds for pharmaceutical applications.KEYWORDS: Dysphania ambrosioidesTFCphytochemical screeningGC-MSantibacterialTPCantioxidant AcknowledgmentsFinancial assistance from the BfR (SFP 1322-807) is thankfully acknowledged.Disclosure StatementNo potential conflict of interest was reported by the author(s).Data Availability StatementData are available on request from the authors.Supplementary MaterialSupplemental data for this article can be accessed online at https://doi.org/10.1080/10496475.2023.2267467","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136112611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-13DOI: 10.1080/10496475.2023.2255164
Sadik Aref
Antioxidative effects of N. sativa were explored using planaria as a model organism. Planaria were cultured in water, N. sativa seed extract, hydrogen peroxide, and a combination of hydrogen peroxide and N. sativa. Planaria were decapitated and observed through stages of regeneration. N. sativa treatment increased Planarian growth, locomotion, and protein. Among hydrogen peroxide stress-induced groups, growth was 92% greater, locomotion was 26% higher, and protein was 86% greater when treated with N. sativa. N. sativa accelerated the regeneration of planaria and minimized the effects of stress. N. sativa can be a promising option for preventing neurodegenerative diseases.
{"title":"Role of <i>Nigella sativa</i> in Preventing Oxidative Stress Damage Using Planaria as Model Organism","authors":"Sadik Aref","doi":"10.1080/10496475.2023.2255164","DOIUrl":"https://doi.org/10.1080/10496475.2023.2255164","url":null,"abstract":"Antioxidative effects of N. sativa were explored using planaria as a model organism. Planaria were cultured in water, N. sativa seed extract, hydrogen peroxide, and a combination of hydrogen peroxide and N. sativa. Planaria were decapitated and observed through stages of regeneration. N. sativa treatment increased Planarian growth, locomotion, and protein. Among hydrogen peroxide stress-induced groups, growth was 92% greater, locomotion was 26% higher, and protein was 86% greater when treated with N. sativa. N. sativa accelerated the regeneration of planaria and minimized the effects of stress. N. sativa can be a promising option for preventing neurodegenerative diseases.","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134989467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-05DOI: 10.1080/10496475.2023.2254284
Ricardo Nunes, Isabel S. Carvalho, P. Paśko, Małgorzata Tyszka – Czochara, Agnieszka Szewczyk, Marek Szlósarczyk, I. Podolak, A. Galanty
{"title":"In Vitro Biological Activity Screening of Arbutus Unedo Leaves in Light of Their Traditional Use","authors":"Ricardo Nunes, Isabel S. Carvalho, P. Paśko, Małgorzata Tyszka – Czochara, Agnieszka Szewczyk, Marek Szlósarczyk, I. Podolak, A. Galanty","doi":"10.1080/10496475.2023.2254284","DOIUrl":"https://doi.org/10.1080/10496475.2023.2254284","url":null,"abstract":"","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85105692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-04DOI: 10.1080/10496475.2023.2253761
Radhalakshmi V, Maya Raman, Minnu Rose Joy
{"title":"Phytochemical profiles, potent antioxidant and antimicrobial activities of betel leaf extracts (Piper betel, Salem Cultivar)","authors":"Radhalakshmi V, Maya Raman, Minnu Rose Joy","doi":"10.1080/10496475.2023.2253761","DOIUrl":"https://doi.org/10.1080/10496475.2023.2253761","url":null,"abstract":"","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78366522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-23DOI: 10.1080/10496475.2023.2248023
S. Raut, G. P. Joshi, D. Pant
{"title":"Evaluation of therapeutic potential of Hypericum species from the Himalaya","authors":"S. Raut, G. P. Joshi, D. Pant","doi":"10.1080/10496475.2023.2248023","DOIUrl":"https://doi.org/10.1080/10496475.2023.2248023","url":null,"abstract":"","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72928474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-21DOI: 10.1080/10496475.2023.2248908
H. Elbouny, B. Ouahzizi, O. Bekkouch, A. Bennani, S. Amrani, M. Ramchoun, K. Sellam, C. Alem
{"title":"Thymus atlanticus Supplementation Attenuates Hepatic Steatosis in High-Fat Diet Fed Guinea Pigs","authors":"H. Elbouny, B. Ouahzizi, O. Bekkouch, A. Bennani, S. Amrani, M. Ramchoun, K. Sellam, C. Alem","doi":"10.1080/10496475.2023.2248908","DOIUrl":"https://doi.org/10.1080/10496475.2023.2248908","url":null,"abstract":"","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77252865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-21DOI: 10.1080/10496475.2023.2248040
H. Goyal, R. C. Gupta, S. Pradhan, R. Goel
{"title":"Antimicrobial and Hepatoprotective Activity of Different Cytotypes of Taraxacum officinale from the Indian Himalayas","authors":"H. Goyal, R. C. Gupta, S. Pradhan, R. Goel","doi":"10.1080/10496475.2023.2248040","DOIUrl":"https://doi.org/10.1080/10496475.2023.2248040","url":null,"abstract":"","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83325709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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