Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats

IF 0.7 4区农林科学 Q3 VETERINARY SCIENCES Ankara Universitesi Veteriner Fakultesi Dergisi Pub Date : 2023-09-21 DOI:10.33988/auvfd.1085562

Nazmiye SEMİZ, Mehmet Zeki Yılmaz DEVECİ

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Abstract

The aim was to investigate the effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil in a full-thickness excisional skin wound model in rats. In the study, 18 adult male Wistar rats were divided into three groups (n=6) as control (CO) group, common centaury oil (CCO) group, and laurel seed oil (LSO) group. Under general anesthesia, a full-thickness excisional wound (2.25 cm²) was created on the caudal of the interscapular region on the back of the rats. Treatments were applied topically once a day in all groups. Wound area measurements revealed that the use of CCO accelerated wound healing, while the use of LSO has disturbed. In the histopathological results, blood vessel formation, fiber synthesis, granulation and mononuclear cells in the wounds were higher in the CCO group than the other groups, and higher in the LSO group than the CO group. Biochemical results revealed differences between groups in TP, GLU and UREA values (p < 0.05). As a result of this study, it was determined that the topical use of common centaury oil accelerated wound healing, while laurel seed oil adversely affected wound healing in the experimental excisional full-thickness skin wound model in rats.

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普通百马油和月桂籽油对大鼠全层切除皮肤创面愈合的影响

目的探讨普通百岁马(Centaurium erythraea)油和月桂(Laurus nobilis)籽油对大鼠全层皮肤切除损伤模型的影响。选用成年雄性Wistar大鼠18只，随机分为3组(n=6)，分别为对照组(CO)、普通世纪油组(CCO)和月桂籽油组(LSO)。全身麻醉下，在大鼠背部肩胛间区尾侧创面全层切除创面(2.25 cm²)。各组均采用局部治疗，每天1次。伤口面积测量显示，使用CCO加速伤口愈合，而使用LSO则受到干扰。组织病理学结果显示，CCO组创面血管形成、纤维合成、肉芽和单核细胞数量均高于其他各组，LSO组创面血管形成、纤维合成、肉芽和单核细胞数量均高于其他各组，LSO组创面血管形成、纤维合成、肉芽和单核细胞数量均高于CO组。生化结果显示各组间TP、GLU和尿素值存在差异(p <0.05)。本研究确定，在实验性大鼠全层皮肤切除创面模型中，局部使用普通世纪油可促进创面愈合，而月桂籽油对创面愈合有不利影响。

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来源期刊

Ankara Universitesi Veteriner Fakultesi Dergisi 农林科学-兽医学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Ankara Üniversitesi Veteriner Fakültesi Dergisi is one of the journals’ of Ankara University, which is the first well-established university in the Republic of Turkey. Research articles, short communications, case reports, letter to editor and invited review articles are published on all aspects of veterinary medicine and animal science. The journal is published on a quarterly since 1954 and indexing in Science Citation Index-Expanded (SCI-Exp) since April 2007.