Development and Evaluation of Curcumin-based Transferosomal Gel for Wound Healing

Abstract

Background: Recently, transferosomes have been discovered to have the potential for transdermal delivery. Curcumin is a bioactive molecule with anti-inflammatory and antioxidant properties, but it has low water solubility and poor skin absorption. The biological response to damage caused by diverse stimuli is known as the inflammatory process. Cyclodextrins are cyclic (-1, 4)-linked oligosaccharides of -D-glucopyranose with a hydrophilic outer surface and a hydrophobic center cavity. Aim: The aim of the study was to develop a curcumin-loaded transferosomal gel to improve the wound healing process. The study has focused on advancing the area of traditional medicine in the field of pharmaceutics by using curcumin in the form of transferosomes to enhance wound healing. Method: Firstly, curcumin was used to synthesize the transferosomes. Secondly, the transferosomes were converted into a transferosomal gel as an alternative for wound healing. Characterization and in vivo investigation were carried out on female Swiss mice. Results: Unpaired Student’s t-test was used to determine the statistical significance at p < 0.5 using UV exposure schedules. All values have been expressed as mean ± SEM calculated by ANOVA with a significant difference among means at P < 0.05. Conclusion: The study has indicated curcumin to be successfully entrapped in transferosomes in order to formulate the gel with powerful wound healing properties.