[Effects of hypophysin and desoxycorticosterone-21-acetate on renal function in calves in the neonatal period. I. Diuresis volume, glomerular filtration rate and urinary excretion of endogenous creatinine].

Abstract

Experiments concerning the influence of hypophysin (0.1 vol. unit/kg) and desoxycorticosterone-21-acetate (0.1 mg/kg) on the size of diuresis, urine condensation and the glomerular filtration process have been carried out on 12 bulls at the age of 2-5 weeks of life. It has been stated that already 2-week old kidneys are able to condensate urine, and kidney water saving under the influence of hypophysin is the result of glomerular filtration decrease and tubular resorption increase. Water and electrolytes stopping under the desoxycorticosterone-21-acetate influence was caused by lowered glomal leaking and intensified process of adsorption in tubules. The lack of higher acidification of urine after acetate injection suggests that kidneys at neonatal period show low activity "re serve" within acid-alkaline balance regulation. It has been pointed out that because of intensive tubular secretion the clearance of endogenous creatinine cannot be the measure of glomerular filtration size.