Evaluated the Effect of Titanium Dioxide Nanoparticles on the Activity of Creatinine and Urea Levels in Dialysis Patients

Abstract

Abstract Nanotechnology is an emerging field that has got a phenomenal interest in the last few decades. Medical application is considered one of the most important ambitions in this field. The objective was to evaluate the biological effects of (TiO2-NPs) on urea and creatinine activity among kidney patients. The titanium dioxide (TiO2) nanoparticles were created using the photocell technique, and for characterization used XRD and TEM. The research population consisted of 60 individuals, both male and female, with renal disease and older than 40 years old who were on dialysis without taking any drugs. Two groups were created out of them (30 control group and 30 dialysis patients group). The two groups' serum was collected using a straightforward sampling approach. Creatinine and urea levels were measured for the control group, and for the dialysis group before the addition of TiO2-NPs; and also after the addition of TiO2-NPs. Furthermore, creatinine and urea concentrations were determined using a spectrophotometric method. The XRD investigations showed that titanium dioxide nanoparticles are crystalline and the size ranged from 11-29 nm, according to photographs taken using TEM. The present investigation showed that (TiO2-NPs) significantly lowered the levels of creatinine and urea in individuals with renal disease. Our findings demonstrated, for the first time, that TiO2 nanoparticles considerably declined the levels of creatinine and urea among dialysis patients. Future research should be done to confirm this affects TiO2-NPs.