Effects of Vitamins E and D on Mechanical Properties of Breast Cancerous Cells

Abstract

aims: . This research aims to determine the short-term impact of vitamin D and E on the mechanical properties of breast cancer cells before comparing them with normal breast cells. background: Several investigations have demonstrated that vitamins can be used to treat or prevent cancer by altering actin filaments, inhibiting cell migration and cancer cell proliferation. Vitamins D and E are fat-soluble objective: MCF-7 breast cancer cells, and MCF-7 breast cancer cells method: Atomic force microscopy (AFM) was used to examine the deformation of MCF-10 normal breast cells, MCF-7 breast cancer cells, and MCF-7 breast cancer cells treated with 0.03 μM vitamin D and 16 μM vitamin E solutions. Young's modulus was calculated employing the Hertz model to determine cell stiffness. result: The Young's modulus of vitamin D-treated cancer cells (585.8 Pa) was substantially similar to that of normal cells (455.6 Pa). Nevertheless, vitamin E treatment had no effect on Young's modulus of cancer cells, which remained remarkably similar to that of untreated cancer cells (216.6 and 203.4 Pa, respectively). conclusion: Despite vitamin E, vitamin D enhances the stiffness of tumor cells and makes their mechanical properties similar to normal cells by interfering with actin filaments and cell skeletons, which may inhibit tumor cell migration. other: According to these findings, vitamin D appears to be an effective drug for cancer treatment.