Drug Repositioning: A Monetary Stratagem to Discover a New Application of Drugs

Q3 Pharmacology, Toxicology and Pharmaceutics Current drug discovery technologies Pub Date : 2023-10-10 DOI:10.2174/0115701638253929230922115127

Seema Rohilla, Ankur Rohilla

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Abstract

Abstract: Drug repurposing, also referred to as drug repositioning or drug reprofiling, is a scientific approach to the detection of any new application for an already approved or investigational drug. It is a useful policy for the invention and development of new pharmacological or therapeutic applications of different drugs. The strategy has been known to offer numerous advantages over developing a completely novel drug for certain problems. Drug repurposing has numerous methodologies that can be categorized as target-oriented, drug-oriented, and problem-oriented. The choice of the methodology of drug repurposing relies on the accessible information about the drug molecule and like pharmacokinetic, pharmacological, physicochemical, and toxicological profile of the drug. In addition, molecular docking studies and other computer-aided methods have been known to show application in drug repurposing. The variation in dosage for original target diseases and novel diseases presents a challenge for researchers of drug repurposing in present times. The present review critically discusses the drugs repurposed for cancer, covid-19, Alzheimer’s, and other diseases, strategies, and challenges of drug repurposing. Moreover, regulatory perspectives related to different countries like the United States (US), Europe, and India have been delineated in the present review.

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药物重新定位:发现药物新用途的货币策略

摘要:药物再利用，也称为药物重新定位或药物重新分析，是一种检测已批准或正在研究的药物的新申请的科学方法。这对于不同药物的新药理或治疗应用的发明和发展是一个有用的政策。与针对某些问题开发一种全新的药物相比，这种策略具有许多优势。药物再利用有许多方法，可分为目标导向、药物导向和问题导向。药物再利用方法的选择依赖于药物分子的可获得信息，如药物的药代动力学、药理学、物理化学和毒理学特征。此外，分子对接研究和其他计算机辅助方法已被证明在药物再利用中有应用。原靶点疾病和新疾病的剂量变化是当前药物再利用研究的一个挑战。本综述批判性地讨论了用于癌症、covid-19、阿尔茨海默病和其他疾病的药物再利用、药物再利用的策略和挑战。此外，本综述还描述了与美国、欧洲和印度等不同国家有关的监管观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug discovery technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.