Efficacy of transdermal microneedling redermalization with high-molecular-weight hyaluronic acid and sodium succinate in the correction of postacne scars

Elena S. Snarskaya, Aleksandr S. Bykanov
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 AIM: to study the efficacy and safety of transdermal redermalization with microneedling using high-molecular-weight hyaluronic acid and sodium succinate in patients with atrophic postacne scars of varying severity.
 MATERIALS AND METHODS: A prospective study was carried out at the Clinic of Skin and Venereal Diseases of the Sechenov University. A. Rakhmanov, Sechenov University, with the participation of 80 patients with postacne scars of varying severity. The Hyalual Perfoskin Complex device was used for microneedling in combination with a sodium succinate preparation based on hyaluronic acid. The apparatus was used in a linear technique along the Langer tension lines and in mutually perpendicular direction, 1015 passes in each area (lower jaw, cheek-curve area, forehead area). Each subject underwent 4 treatments at 21-day intervals. Clinical assessment of the treatment dynamics before and after treatment was performed using the Miravex 3D multispectral imaging device. Before and after treatment, patients were evaluated for the severity of postacne scars according to the International Qualitative Scale for the classification of postacne scars, as well as a dermatological index of quality of life. Subjective evaluation of the effectiveness of therapy by the physician and the patient was performed using the International Global Aesthetic Improvement Scale one month after each treatment and 3 months after the last treatment.
 RESULTS: Among the 80 patients, 47 women and 33 men aged 18 to 46 years had atrophic postacne scars of varying severity: I in 9, II in 26, III in 40, and IV in 5 patients; the rashes were most often localized to the cheek-cusp (55; 69%) and forehead (15; 19%) and were represented by U-shaped (35; 44%), V-shaped (17; 21%), M-shaped (19; 24%) and macular (9; 11%) patterns. The duration of the disease averaged 5.33.2 years. Improvement of the clinical picture was observed in 92.5% of cases after treatment. For example, 8 patients with I degree of scarring managed to achieve complete clearing of the skin; out of 26 patients with II degree of scarring, 15 patients achieved I degree of severity and 10 patients experienced clinical remission at the end of treatment; in the group of patients with III degree of scarring (n=40), 18 patients had I degree of severity, 20 patients had II degree of severity; in the group of patients with IV degree of severity after 4 treatments, 2 patients had III degree of severity and 1 patient had II degree of severity. The dermatological quality of life index decreased by 77% on the average: from 18.632.28 to 4.253.16. The final result was considered \"optimal aesthetic result\" by doctors and patients in 86% and 82% of cases, respectively, \"significant improvement\" in 4% and 12% of cases, respectively, \"improvement\" in 2.5% and 4% of cases, respectively, and \"no change\" in 7.5% and 2%, respectively. All patients noted good tolerability of treatment. Thus, side effects in the form of skin redness and painful sensations were insignificant and passed on their own within 23 days after the procedure.
 CONCLUSION: Microneedling with high-molecular-weight hyaluronic acid and sodium succinate has demonstrated high efficacy and safety in the treatment of postacne scars of varying severity. The minimal invasiveness and affordability of the procedure result in high patient adherence to therapy.","PeriodicalId":487039,"journal":{"name":"Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei","volume":"17 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17816/dv159401","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract

BACKGROUND: Acne is a chronic inflammatory skin disease of multifactorial nature that affects more than 80% of adolescents and is one of the top 10 most common diseases in the world. Currently, dermatologists have various techniques for the correction of postacne scars: from minimally invasive hydroxy acid peels to surgical excision of scar tissue. One of the most effective, affordable, and at the same time minimally invasive and safe treatment methods is microneedling ― micro-damage of the skin with thin needles in the lesion area, stimulating the production of collagen and elastin. AIM: to study the efficacy and safety of transdermal redermalization with microneedling using high-molecular-weight hyaluronic acid and sodium succinate in patients with atrophic postacne scars of varying severity. MATERIALS AND METHODS: A prospective study was carried out at the Clinic of Skin and Venereal Diseases of the Sechenov University. A. Rakhmanov, Sechenov University, with the participation of 80 patients with postacne scars of varying severity. The Hyalual Perfoskin Complex device was used for microneedling in combination with a sodium succinate preparation based on hyaluronic acid. The apparatus was used in a linear technique along the Langer tension lines and in mutually perpendicular direction, 1015 passes in each area (lower jaw, cheek-curve area, forehead area). Each subject underwent 4 treatments at 21-day intervals. Clinical assessment of the treatment dynamics before and after treatment was performed using the Miravex 3D multispectral imaging device. Before and after treatment, patients were evaluated for the severity of postacne scars according to the International Qualitative Scale for the classification of postacne scars, as well as a dermatological index of quality of life. Subjective evaluation of the effectiveness of therapy by the physician and the patient was performed using the International Global Aesthetic Improvement Scale one month after each treatment and 3 months after the last treatment. RESULTS: Among the 80 patients, 47 women and 33 men aged 18 to 46 years had atrophic postacne scars of varying severity: I in 9, II in 26, III in 40, and IV in 5 patients; the rashes were most often localized to the cheek-cusp (55; 69%) and forehead (15; 19%) and were represented by U-shaped (35; 44%), V-shaped (17; 21%), M-shaped (19; 24%) and macular (9; 11%) patterns. The duration of the disease averaged 5.33.2 years. Improvement of the clinical picture was observed in 92.5% of cases after treatment. For example, 8 patients with I degree of scarring managed to achieve complete clearing of the skin; out of 26 patients with II degree of scarring, 15 patients achieved I degree of severity and 10 patients experienced clinical remission at the end of treatment; in the group of patients with III degree of scarring (n=40), 18 patients had I degree of severity, 20 patients had II degree of severity; in the group of patients with IV degree of severity after 4 treatments, 2 patients had III degree of severity and 1 patient had II degree of severity. The dermatological quality of life index decreased by 77% on the average: from 18.632.28 to 4.253.16. The final result was considered "optimal aesthetic result" by doctors and patients in 86% and 82% of cases, respectively, "significant improvement" in 4% and 12% of cases, respectively, "improvement" in 2.5% and 4% of cases, respectively, and "no change" in 7.5% and 2%, respectively. All patients noted good tolerability of treatment. Thus, side effects in the form of skin redness and painful sensations were insignificant and passed on their own within 23 days after the procedure. CONCLUSION: Microneedling with high-molecular-weight hyaluronic acid and sodium succinate has demonstrated high efficacy and safety in the treatment of postacne scars of varying severity. The minimal invasiveness and affordability of the procedure result in high patient adherence to therapy.
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高分子量透明质酸联合琥珀酸钠经皮微针再皮肤化治疗痤疮后疤痕的疗效观察
背景:痤疮是一种多因素的慢性炎症性皮肤病,影响80%以上的青少年,是世界上十大最常见疾病之一。目前,皮肤科医生有各种各样的技术来纠正痤疮后疤痕:从微创果酸剥去到手术切除疤痕组织。微针治疗是一种最有效、最经济、同时也是微创和安全的治疗方法之一——用细针在病变区域对皮肤进行微损伤,刺激胶原蛋白和弹性蛋白的产生。目的:探讨高分子量透明质酸联合琥珀酸钠微针经皮再皮肤化治疗不同严重程度萎缩性痤疮后瘢痕的疗效和安全性;材料和方法:在谢切诺夫大学皮肤和性病诊所进行了一项前瞻性研究。A. Rakhmanov,谢切诺夫大学,参与了80名不同严重程度的痤疮后疤痕患者。采用透明质酸为基础的琥珀酸钠制剂与透明质酸Perfoskin复合物装置联合进行微针注射。仪器沿兰格张力线沿相互垂直方向线性使用,每个区域(下颚、脸颊曲线区、前额区)均通过1015次。每名受试者接受4次治疗,间隔21天。使用Miravex 3D多光谱成像设备对治疗前后的治疗动态进行临床评估。治疗前后,根据国际痤疮后疤痕分类定性量表(International Qualitative Scale)和生活质量皮肤科指数对患者痤疮后疤痕的严重程度进行评估。每次治疗后1个月及末次治疗后3个月采用国际美容改善量表对治疗效果进行主观评价。 结果:80例患者中,女性47例,男性33例,年龄18 ~ 46岁,有不同程度的萎缩性痤疮后瘢痕:I型9例,II型26例,III型40例,IV型5例;皮疹最常局限于颊尖(55;69%)和前额(15%;19%),以u型(35;44%), v型(17%;21%), m型(19;24%)和黄斑(9;11%)模式。病程平均为5.33.2年。92.5%的病例经治疗后临床症状有所改善。例如,8例I级疤痕患者成功实现皮肤完全清除;26例II级瘢痕患者中,15例患者在治疗结束时达到I级严重程度,10例患者临床缓解;ⅲ级瘢痕组(n=40),ⅰ级瘢痕组18例,ⅱ级瘢痕组20例;4次治疗后严重程度为IV级的患者组中,2例严重程度为III级,1例严重程度为II级。皮肤病生活质量指数平均下降77%,由18.632.28降至4.253.16。医生和患者认为最终结果为“最佳美学效果”的分别为86%和82%,“显著改善”的分别为4%和12%,“改善”的分别为2.5%和4%,“无变化”的分别为7.5%和2%。所有患者均表现出良好的治疗耐受性。因此,以皮肤发红和疼痛为形式的副作用是微不足道的,并在手术后23天内自行消失。 结论:高分子量透明质酸与琥珀酸钠联合微针治疗不同严重程度的痤疮后疤痕具有较高的疗效和安全性。微创性和可负担性使得患者对治疗的依从性很高。
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Chronicles of A.I. Pospelov Moscow Society of Dermatovenerologists and Cosmetologists (MSDC was founded on October 4, 1891) Bulletin of the MSDC meeting N 1152 Modern view on rosacea: Topical issues of epidemiology, pathogenesis and therapy. Literature review On the issue of tolerability and safety of phototherapy in patients with psoriasis Clinical and pathogenetic justification of the use of azathioprine in the treatment of progressive non-segmental vitiligo Efficacy of transdermal microneedling redermalization with high-molecular-weight hyaluronic acid and sodium succinate in the correction of postacne scars
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