Formulation and Evaluation of Aspirin Nanosuspension Using Probe Sonication Method

Abstract

Aspirin inhibit the activity of the enzyme now called cyclooxygenase (COX) which leads to the formation of prostaglandins (PGs) that cause inflammation, swelling, pain and fever. Aspirin having various function like anti-inflammatory, analgesic, antipyretic etc. Aspirin loaded nanosuspension was prepared to enhance the bioavailability of the drug. Nanosuspension is defined as a finely dispersed solid particle dissolved in aqueous and organic medium for oral, tropical, parenteral or pulmonary administration. The size ranges about 200nm to 600nm.Aspirin loaded nanosuspension was prepared by probe sonication method. The probe sonication method is used to reduce the particle size and to increase the solubility of the drug. Total 5 Nano formulations were prepared in which NS1 shows 100% of drug content. Invitro Drug release was performed using Franz diffusion cell in which NS5 formulation shows 94.7% drug release in a time period of two hours and 30 minutes. Entrapment efficiency was performed using Ultracentrifugation method kept for 40 minutes at 17,000 rpm speed. Among all NS5 shows 71.9% of entrapment efficiency.