Background: Intracranial hypotension (IH) is a clinical manifestation of low cerebrospinal fluid pressure with reports of isolated cortical venous thrombosis (ICVT) rarely described. Case Presentation: A 23-year-old man presented with postural headache followed by blurry vision and horizontal binocular diplopia with extreme gaze. Patient workup showed diffuse thickening and enhancement of the dura suggestive of intracranial hypotension and biparietal superficial cortical vein thrombosis was noted on imaging. The patient was started on folate and therapeutic anticoagulation and his condition improved. Conclusion: Patients with IH are at risk for CVT due to the dilation of the venous sinuses of the brain. Changes in the characteristics of the headache of the patient or the onset of new neurological symptoms should warrant further investigation. Prophylactic systemic anticoagulation might cautiously be indicated in high-risk patients with IH to prevent ICVT.
{"title":"Intracranial Hypotension and Bilateral Isolated Cortical Vein Thrombosis: A Case Report and Literature Review","authors":"Andreas Filippaios","doi":"10.31579/2690-4861/316","DOIUrl":"https://doi.org/10.31579/2690-4861/316","url":null,"abstract":"Background: Intracranial hypotension (IH) is a clinical manifestation of low cerebrospinal fluid pressure with reports of isolated cortical venous thrombosis (ICVT) rarely described. Case Presentation: A 23-year-old man presented with postural headache followed by blurry vision and horizontal binocular diplopia with extreme gaze. Patient workup showed diffuse thickening and enhancement of the dura suggestive of intracranial hypotension and biparietal superficial cortical vein thrombosis was noted on imaging. The patient was started on folate and therapeutic anticoagulation and his condition improved. Conclusion: Patients with IH are at risk for CVT due to the dilation of the venous sinuses of the brain. Changes in the characteristics of the headache of the patient or the onset of new neurological symptoms should warrant further investigation. Prophylactic systemic anticoagulation might cautiously be indicated in high-risk patients with IH to prevent ICVT.","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Knee osteoarthritis (KOA) is one of the most common degenerative diseases that can lead to disability and pain. The degenerative nature of this condition cannot be reversed or healed by any currently available treatments. Recently, there has been an upcoming interest in treating degenerative tissue disorders with minimally invasive autologous blood products. Autologous blood was preconditioned with gold particles to encourage the production of various proteins in patients’ blood. This current study investigated the safety and efficacy of pre-conditioning autologous blood with gold particles (GOLDIC®) in patients with severe knee osteoarthritis (KOA). Case presentation We report a case in which four intra-articular GOLDIC® injections were used to treat knee osteoarthritis. After a week, physiotherapy was recommended. Before and three weeks after the injections, she was assessed for her weight, the Visual Analog Scale (VAS), and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) score. GOLDIC® treatment resulted in significant weight, VAS, and WOMAC score improvements without serious side effects. Conclusion Due to the one-time blood harvesting and only four injections, the initial results demonstrated that the treatment plan is safe, less expensive, patient-friendly, and more successful at achieving compliance. This GOLDIC® treatment can significantly decrease pain and improve knee capability with overall satisfaction over a significant period. To fully validate the real potential of GOLDIC® in heterogeneous patient populations and to compare these promising results to other blood-based platforms, future randomized-controlled trials with long-term follow-up are required, despite the promising early clinical results.
{"title":"Gold-Induced Cytokine (Goldic®) – A Promising Treatment in Patients with Grade 4 Knee Osteoarthritis: A Case Study","authors":"Pooja Pithadia","doi":"10.31579/2690-4861/318","DOIUrl":"https://doi.org/10.31579/2690-4861/318","url":null,"abstract":"Background: Knee osteoarthritis (KOA) is one of the most common degenerative diseases that can lead to disability and pain. The degenerative nature of this condition cannot be reversed or healed by any currently available treatments. Recently, there has been an upcoming interest in treating degenerative tissue disorders with minimally invasive autologous blood products. Autologous blood was preconditioned with gold particles to encourage the production of various proteins in patients’ blood. This current study investigated the safety and efficacy of pre-conditioning autologous blood with gold particles (GOLDIC®) in patients with severe knee osteoarthritis (KOA). Case presentation We report a case in which four intra-articular GOLDIC® injections were used to treat knee osteoarthritis. After a week, physiotherapy was recommended. Before and three weeks after the injections, she was assessed for her weight, the Visual Analog Scale (VAS), and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) score. GOLDIC® treatment resulted in significant weight, VAS, and WOMAC score improvements without serious side effects. Conclusion Due to the one-time blood harvesting and only four injections, the initial results demonstrated that the treatment plan is safe, less expensive, patient-friendly, and more successful at achieving compliance. This GOLDIC® treatment can significantly decrease pain and improve knee capability with overall satisfaction over a significant period. To fully validate the real potential of GOLDIC® in heterogeneous patient populations and to compare these promising results to other blood-based platforms, future randomized-controlled trials with long-term follow-up are required, despite the promising early clinical results.","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aloe vera has a storied history of use. Mesopotamian clay tablets dated 1750 BC indicate that Aloe vera was being used for medicinal purposes. Egyptian records from 550 BC also mentioned aloe for infections of the skin. The ancient Greeks were also aware of aloe’s medicinal effects as both Pliny (23-79 AD) and Dioscorides (1st century AD) wrote of aloe’s ability to treat wounds and heal infections of the skin. Aloe vera is still widely used in many traditional systems of medicine.
{"title":"A Brief Review on Aloe Vera & Aloe Vera Gel","authors":"Mohammad Kamil","doi":"10.31579/2690-4861/313","DOIUrl":"https://doi.org/10.31579/2690-4861/313","url":null,"abstract":"Aloe vera has a storied history of use. Mesopotamian clay tablets dated 1750 BC indicate that Aloe vera was being used for medicinal purposes. Egyptian records from 550 BC also mentioned aloe for infections of the skin. The ancient Greeks were also aware of aloe’s medicinal effects as both Pliny (23-79 AD) and Dioscorides (1st century AD) wrote of aloe’s ability to treat wounds and heal infections of the skin. Aloe vera is still widely used in many traditional systems of medicine.","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"9 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aspirin inhibit the activity of the enzyme now called cyclooxygenase (COX) which leads to the formation of prostaglandins (PGs) that cause inflammation, swelling, pain and fever. Aspirin having various function like anti-inflammatory, analgesic, antipyretic etc. Aspirin loaded nanosuspension was prepared to enhance the bioavailability of the drug. Nanosuspension is defined as a finely dispersed solid particle dissolved in aqueous and organic medium for oral, tropical, parenteral or pulmonary administration. The size ranges about 200nm to 600nm.Aspirin loaded nanosuspension was prepared by probe sonication method. The probe sonication method is used to reduce the particle size and to increase the solubility of the drug. Total 5 Nano formulations were prepared in which NS1 shows 100% of drug content. Invitro Drug release was performed using Franz diffusion cell in which NS5 formulation shows 94.7% drug release in a time period of two hours and 30 minutes. Entrapment efficiency was performed using Ultracentrifugation method kept for 40 minutes at 17,000 rpm speed. Among all NS5 shows 71.9% of entrapment efficiency.
{"title":"Formulation and Evaluation of Aspirin Nanosuspension Using Probe Sonication Method","authors":"A. Krishna Sailaja","doi":"10.31579/2690-4861/314","DOIUrl":"https://doi.org/10.31579/2690-4861/314","url":null,"abstract":"Aspirin inhibit the activity of the enzyme now called cyclooxygenase (COX) which leads to the formation of prostaglandins (PGs) that cause inflammation, swelling, pain and fever. Aspirin having various function like anti-inflammatory, analgesic, antipyretic etc. Aspirin loaded nanosuspension was prepared to enhance the bioavailability of the drug. Nanosuspension is defined as a finely dispersed solid particle dissolved in aqueous and organic medium for oral, tropical, parenteral or pulmonary administration. The size ranges about 200nm to 600nm.Aspirin loaded nanosuspension was prepared by probe sonication method. The probe sonication method is used to reduce the particle size and to increase the solubility of the drug. Total 5 Nano formulations were prepared in which NS1 shows 100% of drug content. Invitro Drug release was performed using Franz diffusion cell in which NS5 formulation shows 94.7% drug release in a time period of two hours and 30 minutes. Entrapment efficiency was performed using Ultracentrifugation method kept for 40 minutes at 17,000 rpm speed. Among all NS5 shows 71.9% of entrapment efficiency.","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"166 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Several studies have emphasized the urgent need for Physical Rehabilitation guidelines for COVID-19 patients and the effect of Early Mobilization (EM) in these patients. previous reports revealed that dealing with COVID-19 patients was based on expert opinion, evidence from patients with other lung diseases, and not on the recent literature concerning COVID-19. International guidelines also reported that early mobilization is safe and feasible, starting in the ICU setting. Therefore, this clinical literature review aimed to designate the indications of physical rehabilitation programs and early mobilization benefits to add to the existing literature the necessary up-to-date recommendations and share the experience of a tertiary healthcare facility in dealing with different stages of post-COVID-19 patients. Conclusion: The multidisciplinary approach of KFSH&RC for rehabilitating COVID-19 patients was integrated through early mobilization and remarkable follow-up of different clinical services divisions including physical and occupational rehabilitation, respiratory therapy, and nutrition, with the collaboration of the medical and psychological teams aiming to regain optimal physical function, psychological well-being, and better quality of life for those populations.
{"title":"A Clinical Review of Physical Rehabilitation Protocol and Early Mobilization Patterns for Post-Covid-19 Patients: Tertiary Health-Care Facility Experience","authors":"Takroni Mohammed","doi":"10.31579/2690-4861/315","DOIUrl":"https://doi.org/10.31579/2690-4861/315","url":null,"abstract":"Several studies have emphasized the urgent need for Physical Rehabilitation guidelines for COVID-19 patients and the effect of Early Mobilization (EM) in these patients. previous reports revealed that dealing with COVID-19 patients was based on expert opinion, evidence from patients with other lung diseases, and not on the recent literature concerning COVID-19. International guidelines also reported that early mobilization is safe and feasible, starting in the ICU setting. Therefore, this clinical literature review aimed to designate the indications of physical rehabilitation programs and early mobilization benefits to add to the existing literature the necessary up-to-date recommendations and share the experience of a tertiary healthcare facility in dealing with different stages of post-COVID-19 patients. Conclusion: The multidisciplinary approach of KFSH&RC for rehabilitating COVID-19 patients was integrated through early mobilization and remarkable follow-up of different clinical services divisions including physical and occupational rehabilitation, respiratory therapy, and nutrition, with the collaboration of the medical and psychological teams aiming to regain optimal physical function, psychological well-being, and better quality of life for those populations.","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bartholomew Forsyth, Lydiya Thomas, Jo Brodie, Ratna Alluri
{"title":"A Painful Axillary Lump: A Rare Case of Talc Granuloma Following Talc Pleurodesis","authors":"Bartholomew Forsyth, Lydiya Thomas, Jo Brodie, Ratna Alluri","doi":"10.46527/2582-5038.258","DOIUrl":"https://doi.org/10.46527/2582-5038.258","url":null,"abstract":"","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87404484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tagar E, Kpolugbo J, Udefiagbon Eo, Akerele W, Okomayin Aa, Odion C, Ozah E
{"title":"Diagnostic Dilemma in Teenage Presentation of Intestinal Malrotation: Report of Two Cases and Review of the Literature","authors":"Tagar E, Kpolugbo J, Udefiagbon Eo, Akerele W, Okomayin Aa, Odion C, Ozah E","doi":"10.46527/2582-5038.257","DOIUrl":"https://doi.org/10.46527/2582-5038.257","url":null,"abstract":"","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75495905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Full Length Sewing Needle in the Stomach of 2 Years-Old Baby: A Case Report","authors":"D. Solomon, Gosaye Debele","doi":"10.46527/2582-5038.260","DOIUrl":"https://doi.org/10.46527/2582-5038.260","url":null,"abstract":"","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87857693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Case Series: Rho Kinase Inhibitor for the Treatment of Corneal Edema after Cataract Surgery in Patients with Low Endothelial Count","authors":"Fermín Silva, Stefanie Guillén Panta, Ricardo Alarcon Ventura, Raul Plasencia Salini, Ana Luisa González Méndez","doi":"10.46527/2582-5038.259","DOIUrl":"https://doi.org/10.46527/2582-5038.259","url":null,"abstract":"","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135046022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ovarian pregnancy is one of the rarest types of ectopic pregnancy. Its preoperative diagnosis remains a challenge because of it presents quite similarly to tubal pregnancy and complicated ovarian cysts. In most cases, histology is necessary to confirm the diagnosis, we present an unruptured ovarian pregnancy in a teenager diagnosed during laparoscopy operation.
{"title":"Unruptured Ovarian ectopic pregnancy in adolescence","authors":"Yang Fan","doi":"10.31579/2690-4861/309","DOIUrl":"https://doi.org/10.31579/2690-4861/309","url":null,"abstract":"Ovarian pregnancy is one of the rarest types of ectopic pregnancy. Its preoperative diagnosis remains a challenge because of it presents quite similarly to tubal pregnancy and complicated ovarian cysts. In most cases, histology is necessary to confirm the diagnosis, we present an unruptured ovarian pregnancy in a teenager diagnosed during laparoscopy operation.","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135439218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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