GENDER-SPECIFIC EFFECTS OF OBESITY ON ALCOHOLIC LIVER DISEASE IN OLDER ADULTS OF DIFFERENT GROUPS AGED 65 AND OVER: A CASE–CONTROL STUDY

Abstract

. Alcoholic liver disease is a common liver disease caused by chronic alcohol consumption and is categorized into fatty liver, alcoholic hepatitis, and alcoholic cirrhosis. This study aimed to examine the relationship between alcoholic liver disease and overweight in older adults, focusing on age and gender differences The study was designed as a retrospective age-matched case-control study using the Chang Gung Research Database (CGRD). The data of this study were collected from January 1, 2018 to December 31, 2022. The subjects were aged over 65 years old with a primary diagnosis of alcoholic liver disease. The experimental group matched gender and age group to conduct a case-control study with a ratio of 1:2 for the control group. The relationship between overweight and alcoholic liver disease was analyzed by logistic regression. The study found that the prevalence of alcoholic liver disease was significantly higher in male than in female. The prevalence of overweight in male with alcoholic liver disease decreased with age distribution. For female, age did not matter much. However, among female aged 65 to 69 years, those who were overweight were more likely to develop alcoholic liver disease than those who were of normal weight. These findings provide guidance for population-specific prevention and treatment strategies and highlight the importance of weight control in aged 65 and over. Particularly in the aging population, attention to weight control and aging, as well as the development of alcoholic liver disease, may improve patient health and quality of life.