Potential anti-inflammatory biomarkers from Myrtaceae essential oils revealed by untargeted metabolomics

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2025-02-16 DOI:10.1080/14786419.2023.2283758

Tatiane Cristina Silva Maiolini , Karen de Jesus Nicácio , Welton Rosa , Daniel de Oliveira Miranda , Mario Ferreira Conceição Santos , Paula Carolina Pires Bueno , João Henrique Ghilardi Lago , Patricia Sartorelli , Danielle Ferreira Dias , Daniela Aparecida Chagas de Paula , Marisi Gomes Soares

{"title":"Potential anti-inflammatory biomarkers from Myrtaceae essential oils revealed by untargeted metabolomics","authors":"Tatiane Cristina Silva Maiolini , Karen de Jesus Nicácio , Welton Rosa , Daniel de Oliveira Miranda , Mario Ferreira Conceição Santos , Paula Carolina Pires Bueno , João Henrique Ghilardi Lago , Patricia Sartorelli , Danielle Ferreira Dias , Daniela Aparecida Chagas de Paula , Marisi Gomes Soares","doi":"10.1080/14786419.2023.2283758","DOIUrl":null,"url":null,"abstract":"<div><div>Many species from Myrtaceae have traditionally been used in traditional medicine as anti-inflammatory, antimicrobial, antidiarrheal, antioxidant and antirheumatic, besides in blood cholesterol reduction. In the present work, the anti-inflammatory activity of essential oils from eighteen Myrtaceae spp. were evaluated according to their ex-vivo anti-inflammatory activity in human blood, and the corresponding biomarkers were determined using untargeted metabolomics data and multivariate data analysis. From these studied species, six displayed anti-inflammatory activity with percentage rates of inhibition of PGE2 release above 70%. Caryophyllene oxide (1), humulene epoxide II (2), β-selinene (3), α-amorphene (4), α-selinene (5), germacrene A (6), β-bisabolene (7), α-muurolene (8), α-humulene (9), β-gurjunene (10), myrcene (11), β-elemene (12), α-cadinol (13), α-copaene (14), E-nerolidol (15) and ledol (16) were annotated as potential anti-inflammatory biomarkers. The results obtained in this study point to essential oils from species of the Myrtaceae family as a rich source of anti-inflammatory agents.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 985-992"},"PeriodicalIF":1.9000,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1478641923022933","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}

引用次数: 0

Abstract

Many species from Myrtaceae have traditionally been used in traditional medicine as anti-inflammatory, antimicrobial, antidiarrheal, antioxidant and antirheumatic, besides in blood cholesterol reduction. In the present work, the anti-inflammatory activity of essential oils from eighteen Myrtaceae spp. were evaluated according to their ex-vivo anti-inflammatory activity in human blood, and the corresponding biomarkers were determined using untargeted metabolomics data and multivariate data analysis. From these studied species, six displayed anti-inflammatory activity with percentage rates of inhibition of PGE2 release above 70%. Caryophyllene oxide (1), humulene epoxide II (2), β-selinene (3), α-amorphene (4), α-selinene (5), germacrene A (6), β-bisabolene (7), α-muurolene (8), α-humulene (9), β-gurjunene (10), myrcene (11), β-elemene (12), α-cadinol (13), α-copaene (14), E-nerolidol (15) and ledol (16) were annotated as potential anti-inflammatory biomarkers. The results obtained in this study point to essential oils from species of the Myrtaceae family as a rich source of anti-inflammatory agents.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

非靶向代谢组学研究揭示桃金娘科精油潜在的抗炎生物标志物。

桃金娘科的许多品种在传统医学中具有抗炎、抗菌、止泻、抗氧化、抗风湿和降低血胆固醇的作用。本研究根据18种桃金娘科植物精油在人体血液中的体外抗炎活性评价其抗炎活性，并利用非靶向代谢组学数据和多变量数据分析确定相应的生物标志物。在这些被研究的物种中，有6种表现出抗炎活性，抑制PGE2释放的百分比在70%以上。氧化石竹烯(1)、环氧葎草烯II(2)、β-亚麻烯(3)、α-阿莫菲烯(4)、α-亚麻烯(5)、烯丙烯A(6)、β-双abolene(7)、α-茂烯(8)、α-葎草烯(9)、β-古朱烯(10)、月桂烯(11)、β-榄香烯(12)、α-cadinol(13)、α-copaene(14)、E-nerolidol(15)和ledol(16)被标记为潜在的抗炎生物标志物。本研究的结果表明，桃金娘科植物的精油是抗炎剂的丰富来源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.