A retrospective cohort study: vaccination status and safety analysis of SARS-CoV-2 vaccine in patients with Wilson's disease.

IF 5.5 3区医学 Q1 IMMUNOLOGY Expert Review of Vaccines Pub Date : 2023-01-01 Epub Date: 2023-12-01 DOI:10.1080/14760584.2023.2288630

Hui Han, Dan Zhao, Xinru Fang, Wenming Yang, Mengli Wang, Qianzhuo Liu, Luyao Wang, Zhihui Ji, Juan Zhang, Zhifeng Hou, Lei Hua, Yu Wang, Limin Wu

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Abstract

Background: Wilson's disease (WD) is a rare hepatic and neurological disorder, which can dramatically worsen by traumatic injuries, surgeries, and infections. No studies have reported safety data of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in WD patients. We aimed to investigate the SARS-CoV-2 vaccination status and post-vaccination adverse events in WD patients.

Methods: This is a multicenter, retrospective, observational study. We investigated the vaccination rates, the type of vaccine, subjective reasons for non-vaccination, and the adverse events following vaccination. Logistic regression analysis was used to assess the correlation between vaccination status and increased Unified Wilson's Disease Rating Scale (UWDRS) scores.

Results: A total of 554 WD patients with a mean (SD) age of 25.3 (10.85) years were included in this study, of whom 336 (60.6%) were males and 218 (39.4%) were females. 368 (66.4%) patients received at least one dose of the SARS-CoV-2 vaccine.186 (33.6%) patients were unvaccinated. Logistic regression analysis showed that vaccination against SARS-CoV-2 was not significantly associated with increased UWDRS scores. The safety analysis demonstrated that 21.2% had post-vaccination adverse events.

Conclusions: In this study, vaccination against SARS-CoV-2 was safe in WD patients, providing evidence for the safety of vaccination in WD patients.

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回顾性队列研究:肝豆状核病患者SARS-CoV-2疫苗接种状况及安全性分析

背景:威尔逊氏病(WD)是一种罕见的肝脏和神经系统疾病，可因创伤性损伤、手术和感染而急剧恶化。没有研究报告在WD患者中接种严重急性呼吸综合征冠状病毒2(中华人民共和国sars - cov -2)疫苗的安全性数据。我们的目的是调查WD患者的SARS-CoV-2疫苗接种情况和疫苗接种后的不良事件。方法:这是一项多中心、回顾性、观察性研究。我们调查了疫苗接种率、疫苗类型、不接种的主观原因以及接种后的不良事件。采用Logistic回归分析评估疫苗接种状况与统一威尔逊氏病评定量表(UWDRS)评分升高之间的相关性。结果:共纳入554例WD患者，平均(SD)年龄25.3(10.85)岁，其中男性336例(60.6%)，女性218例(39.4%)。368例(66.4%)患者至少接种了一剂SARS-CoV-2疫苗(33.6%)患者未接种疫苗。Logistic回归分析显示，接种SARS-CoV-2疫苗与UWDRS评分升高无显著相关。安全性分析显示，21.2%的疫苗接种后出现不良事件。结论:在本研究中，WD患者接种SARS-CoV-2疫苗是安全的，为WD患者接种疫苗的安全性提供了证据。

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来源期刊

Expert Review of Vaccines 医学-免疫学

CiteScore

9.10

自引率

3.20%

发文量

136

审稿时长

4-8 weeks

期刊介绍： Expert Review of Vaccines (ISSN 1476-0584) provides expert commentary on the development, application, and clinical effectiveness of new vaccines. Coverage includes vaccine technology, vaccine adjuvants, prophylactic vaccines, therapeutic vaccines, AIDS vaccines and vaccines for defence against bioterrorism. All articles are subject to rigorous peer-review. The vaccine field has been transformed by recent technological advances, but there remain many challenges in the delivery of cost-effective, safe vaccines. Expert Review of Vaccines facilitates decision making to drive forward this exciting field.