{"title":"Briastecholide N: a New Chlorine-Containing Briarane Diterpenoid Deriving from Cultured","authors":"You-Ying Chen, Yueh-Wen Liu, Su-Ying Chien, Yu-Cheng Chen, Fu-Ching Chiu, Po-Wei Huang, I-Li Su, Zhi-Hong Wen, Hung-Tsung Lee, and Ping-Jyun Sung","doi":"10.3987/com-23-14911","DOIUrl":null,"url":null,"abstract":"<span>A new chlorine-containing briarane-type diterpenoid, briastecholide N (</span><span>1</span><span>) was isolated from cultured octocoral </span><span>Briareum stechei</span><span> </span><span>via</span><span> chemical screening. The structure of </span><span>1</span><span> was corroborated by 2D NMR experiments and confirmed backed by single-crystal X-ray diffraction analysis. The study found that </span><span>1</span><span> is capable of increasing the release of alkaline phosphatse (ALP) at </span><span>10 μM.</span><span><br/></span>","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":"137 4","pages":""},"PeriodicalIF":0.8000,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heterocycles","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3987/com-23-14911","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A new chlorine-containing briarane-type diterpenoid, briastecholide N (1) was isolated from cultured octocoral Briareum stecheivia chemical screening. The structure of 1 was corroborated by 2D NMR experiments and confirmed backed by single-crystal X-ray diffraction analysis. The study found that 1 is capable of increasing the release of alkaline phosphatse (ALP) at 10 μM.
期刊介绍：
Since its inception in 1973 HETEROCYCLES has provided a platform for the rapid exchange of research in the areas of organic, pharmaceutical, analytical, and medicinal chemistry of heterocyclic compounds in addition to communications, papers, reviews, a special section of the journal presents newly-discovered natural products whose structure has recently been established.
Another section is devoted to the total synthesis of previously documented natural products with heterocyclic ring systems.
Due to the fact that the journal is able to publish articles within two months of receipt of the manuscripts, researchers in this field can obtain up-to-date information on heterocyclic research by reading Heterocycles regularly.
Audience: Organic and Physical Organic Chemists, Biochemists, Pharmacologists and Scientists studying heterocyclic compounds
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