{"title":"Chemical Structures","authors":"a","doi":"10.3987/com-23-14924","DOIUrl":null,"url":null,"abstract":"<span>From the peels of </span><span>Citrus sphaerocarpa</span><span>, two new limonoids, sphaerocarpain Ⅰ</span><span> </span><span>and Ⅱ were isolated together with five known compounds including methyl deacetylnomilinate and ichangin. The chemical structures of the new compounds were elucidated based on chemical/physicochemical evidence.</span><span> </span><span>For sphaerocarpain Ⅰ and Ⅱ, the absolute configuration was established by comparison of experimental and predicted electronic circular dichroism (ECD) data. Among the isolated compounds, sphaerocarpain I, II, methyl deacetylnomilinate and ichangin showed cytotoxic activity against both human neuroblastoma cells (SH-SY5Y) and human glioblastoma cells (U-251 MG). <br/></span>","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":"136 1","pages":""},"PeriodicalIF":0.8000,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heterocycles","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3987/com-23-14924","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
From the peels of Citrus sphaerocarpa, two new limonoids, sphaerocarpain Ⅰand Ⅱ were isolated together with five known compounds including methyl deacetylnomilinate and ichangin. The chemical structures of the new compounds were elucidated based on chemical/physicochemical evidence.For sphaerocarpain Ⅰ and Ⅱ, the absolute configuration was established by comparison of experimental and predicted electronic circular dichroism (ECD) data. Among the isolated compounds, sphaerocarpain I, II, methyl deacetylnomilinate and ichangin showed cytotoxic activity against both human neuroblastoma cells (SH-SY5Y) and human glioblastoma cells (U-251 MG).
期刊介绍：
Since its inception in 1973 HETEROCYCLES has provided a platform for the rapid exchange of research in the areas of organic, pharmaceutical, analytical, and medicinal chemistry of heterocyclic compounds in addition to communications, papers, reviews, a special section of the journal presents newly-discovered natural products whose structure has recently been established.
Another section is devoted to the total synthesis of previously documented natural products with heterocyclic ring systems.
Due to the fact that the journal is able to publish articles within two months of receipt of the manuscripts, researchers in this field can obtain up-to-date information on heterocyclic research by reading Heterocycles regularly.
Audience: Organic and Physical Organic Chemists, Biochemists, Pharmacologists and Scientists studying heterocyclic compounds
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