{"title":"Diterpene Glycosides Derived from","authors":"Have Immunomodulatory Effects","doi":"10.3987/com-23-14919","DOIUrl":null,"url":null,"abstract":"<span>Senescence-associated secretory phenotype (SASP) factors, involved in inflammation and tumorigenesis, can be inhibited by CD39, which degrades extracellular ATP. In this study, we analysed the chemical composition of the extracts of </span><span>Aster spathulifolius</span><span>, a coastal medicinal plant belonging to the Asteraceae family, and thereafter, isolated and determined the structures of the active components. We also treated THP-1 cells with the </span><span>A. spathulifolius</span><span> extracts and observed CD39 expression. Nine secondary metabolites, including a new diterpene glycoside </span><span>1</span><span>, were isolated. Compounds </span><span>1</span><span> and </span><span>3</span><span>–</span><span>7</span><span> substantially promoted CD39 expression in THP-1 cells, and compound </span><span>3</span><span>, the abundant component, showed the strongest effect in this regard, possibly degrading ATP and inhibiting the SASP. <br/></span>","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heterocycles","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3987/com-23-14919","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Senescence-associated secretory phenotype (SASP) factors, involved in inflammation and tumorigenesis, can be inhibited by CD39, which degrades extracellular ATP. In this study, we analysed the chemical composition of the extracts of Aster spathulifolius, a coastal medicinal plant belonging to the Asteraceae family, and thereafter, isolated and determined the structures of the active components. We also treated THP-1 cells with the A. spathulifolius extracts and observed CD39 expression. Nine secondary metabolites, including a new diterpene glycoside 1, were isolated. Compounds 1 and 3–7 substantially promoted CD39 expression in THP-1 cells, and compound 3, the abundant component, showed the strongest effect in this regard, possibly degrading ATP and inhibiting the SASP.
期刊介绍：
Since its inception in 1973 HETEROCYCLES has provided a platform for the rapid exchange of research in the areas of organic, pharmaceutical, analytical, and medicinal chemistry of heterocyclic compounds in addition to communications, papers, reviews, a special section of the journal presents newly-discovered natural products whose structure has recently been established.
Another section is devoted to the total synthesis of previously documented natural products with heterocyclic ring systems.
Due to the fact that the journal is able to publish articles within two months of receipt of the manuscripts, researchers in this field can obtain up-to-date information on heterocyclic research by reading Heterocycles regularly.
Audience: Organic and Physical Organic Chemists, Biochemists, Pharmacologists and Scientists studying heterocyclic compounds
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