Synthesis, Antioxidant Activity

IF 0.8 4区 化学 Q4 CHEMISTRY, ORGANIC Heterocycles Pub Date : 2023-11-06 DOI:10.3987/com-23-14915
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Abstract

3-[2-(5-Aryl-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4-yl]-4- hydroxy-6-methyl-2H-pyran-2-ones 6a-h were synthesized via the ring closure reactions of 3-phenyl-5-aryl-4,5-dihydropyrazole-1-carbothioamides 3a-h with 3-(bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one 5. The new synthesized thiazolyl-pyrazolinyl-pyran-2-one compounds were evaluated for their potential antioxidant activity by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical method. The molecular docking of the synthesized compounds on DPPH oxidase protein showed a high binding affinity, confirming the experimental results recorded. The synthesized compounds deserve a consideration for further analyses regarding the control of oxidative stress and their use as possible antioxidant agents in the pharmaceutical industry.

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合成、抗氧化活性
3-[2-(5-芳基-3-苯基-4,5-二氢- 1h -吡唑-1-酰基)噻唑-4-酰基]-4-羟基-6-甲基- 2h -吡喃-2- 1- 6a-h是由3-(溴乙酰基)-4-羟基-6-甲基- 2h -吡喃-2- 1- 5与3-(溴乙酰基)闭合环反应合成的。用2,2-二苯基-1-吡啶肼(DPPH)自由基法评价了新合成的噻唑基-吡唑啉基-吡喃-2- 1化合物的潜在抗氧化活性。合成的化合物与DPPH氧化酶蛋白的分子对接显示出较高的结合亲和力,证实了实验记录的结果。合成的化合物值得进一步分析氧化应激的控制及其在制药工业中作为抗氧化剂的可能用途。
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来源期刊
Heterocycles
Heterocycles 化学-有机化学
CiteScore
1.50
自引率
0.00%
发文量
108
审稿时长
1 months
期刊介绍: Since its inception in 1973 HETEROCYCLES has provided a platform for the rapid exchange of research in the areas of organic, pharmaceutical, analytical, and medicinal chemistry of heterocyclic compounds in addition to communications, papers, reviews, a special section of the journal presents newly-discovered natural products whose structure has recently been established. Another section is devoted to the total synthesis of previously documented natural products with heterocyclic ring systems. Due to the fact that the journal is able to publish articles within two months of receipt of the manuscripts, researchers in this field can obtain up-to-date information on heterocyclic research by reading Heterocycles regularly. Audience: Organic and Physical Organic Chemists, Biochemists, Pharmacologists and Scientists studying heterocyclic compounds
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