-pyrazolylmethyleneindoles and Their Antifungal Activities
{"title":"Synthesis of Thiosemicarbazone Derivatives of 3-Formyl-","authors":"-pyrazolylmethyleneindoles and Their Antifungal Activities","doi":"10.3987/com-23-14870","DOIUrl":null,"url":null,"abstract":"<span>In order to discover natural-product-based </span><span>antifungal</span><span> candidates, a series of new </span><span>thiosemicarbazone derivatives of 3-formyl-</span><span>N</span><span>-pyrazolylmethyleneindoles</span><span> were prepared. Some derivatives showed good </span><span>antifungal</span><span> activities. Against </span><span>Curvularia lunata</span><span>,</span><span> compound </span><span>I-2</span><span> showed 2.2 times </span><span>antifungal activity</span><span> compared to the </span><span>precursor indole</span><span>. Against</span><span> Valsa mali</span><span>,</span><span> compound </span><span>Ⅰ-1</span><span> exhibited 1.7 times </span><span>antifungal</span><span> activity compared to </span><span>indole.</span>","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":"136 6","pages":""},"PeriodicalIF":0.8000,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heterocycles","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3987/com-23-14870","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
In order to discover natural-product-based antifungal candidates, a series of new thiosemicarbazone derivatives of 3-formyl-N-pyrazolylmethyleneindoles were prepared. Some derivatives showed good antifungal activities. Against Curvularia lunata, compound I-2 showed 2.2 times antifungal activity compared to the precursor indole. Against Valsa mali, compound Ⅰ-1 exhibited 1.7 times antifungal activity compared to indole.
期刊介绍：
Since its inception in 1973 HETEROCYCLES has provided a platform for the rapid exchange of research in the areas of organic, pharmaceutical, analytical, and medicinal chemistry of heterocyclic compounds in addition to communications, papers, reviews, a special section of the journal presents newly-discovered natural products whose structure has recently been established.
Another section is devoted to the total synthesis of previously documented natural products with heterocyclic ring systems.
Due to the fact that the journal is able to publish articles within two months of receipt of the manuscripts, researchers in this field can obtain up-to-date information on heterocyclic research by reading Heterocycles regularly.
Audience: Organic and Physical Organic Chemists, Biochemists, Pharmacologists and Scientists studying heterocyclic compounds
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