Hydroxyapatite as an active ingredient in oral care: an international symposium report

IF 1.3 4区 工程技术 Q4 ENGINEERING, BIOMEDICAL Bioinspired Biomimetic and Nanobiomaterials Pub Date : 2023-12-06 DOI:10.1680/jbibn.23.00034
Malgorzata Pawinska, Elzbieta Paszynska, Hardy Limeback, Bennett T Amaechi, Helge-Otto Fabritius, Bernhard Ganss, Kelsey O’Hagan-Wong, Erik Schulze zur Wiesche, Frederic Meyer, Joachim Enax
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Abstract

Hydroxyapatite, Ca5(PO4)3(OH), is a bio-inspired active ingredient for preventive oral health care. The use of hydroxyapatite in the prevention of oral diseases has gained, especially in recent years. Hydroxyapatite can be used in-office and for daily oral care (e.g., in toothpastes and mouthwashes). The first clinical efficacy studies on caries prevention and reduction of symptoms of dentin hypersensitivity were conducted in the 1980s. This was followed by various in vitro and in situ studies and several more recent clinical trials. A number of systematic reviews and meta-analyses on the use of hydroxyapatite in preventing oral health problems have been published. Summarizing these data, hydroxyapatite is a versatile active ingredient with multiple benefits that include caries prevention, relief from dentin hypersensitivity, and tooth whitening. Since this calcium phosphate mineral has an excellent biocompatibility, it is safe for all patient groups. This interdisciplinary review gives an overview of the developments in hydroxyapatite research, highlights the research progress made regarding hydroxyapatite as a biomimetic active ingredient, and summarizes the state-of-the-art evidence in support of hydroxyapatite efficacy.
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羟基磷灰石作为口腔护理的有效成分:国际研讨会报告
羟基磷灰石,Ca5(PO4)3(OH),是一种生物启发活性成分,用于预防性口腔保健。特别是近年来,羟基磷灰石在口腔疾病预防中的应用越来越广泛。羟基磷灰石可用于办公室和日常口腔护理(如牙膏和漱口水)。20世纪80年代首次进行了预防龋齿和减轻牙本质过敏症状的临床疗效研究。随后进行了各种体外和原位研究以及最近的一些临床试验。许多关于羟基磷灰石在预防口腔健康问题中的应用的系统综述和荟萃分析已经发表。总结这些数据,羟基磷灰石是一种多功能的活性成分,具有多种益处,包括预防龋齿,缓解牙本质过敏和牙齿美白。由于这种磷酸钙矿物具有良好的生物相容性,因此对所有患者群体都是安全的。这篇跨学科综述综述了羟基磷灰石的研究进展,重点介绍了羟基磷灰石作为仿生活性成分的研究进展,并总结了支持羟基磷灰石疗效的最新证据。
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来源期刊
Bioinspired Biomimetic and Nanobiomaterials
Bioinspired Biomimetic and Nanobiomaterials ENGINEERING, BIOMEDICAL-MATERIALS SCIENCE, BIOMATERIALS
CiteScore
2.20
自引率
0.00%
发文量
12
期刊介绍: Bioinspired, biomimetic and nanobiomaterials are emerging as the most promising area of research within the area of biological materials science and engineering. The technological significance of this area is immense for applications as diverse as tissue engineering and drug delivery biosystems to biomimicked sensors and optical devices. Bioinspired, Biomimetic and Nanobiomaterials provides a unique scholarly forum for discussion and reporting of structure sensitive functional properties of nature inspired materials.
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