To solve the problems of traditional drug carriers such as their single structure and lack of graded release, this work designs and synthesizes a kind of microporous–mesoporous silica tube (MST) with a macroporous and mesoporous structure. Then, manganese dioxide (MnO2) nanoparticles prepared using the hydrothermal method are embedded in the macropores to form an MST/Mn micromotor, which is then loaded with heparin and urokinase for thrombolytic therapy. The motion behavior of the micromotor is also investigated. Both static and dynamic thrombolytic therapy are detected, and the results indicate that a better thrombolytic effect can be observed on the MST/manganese micromotor with a motion ability compared with the samples without a motion ability. This research is expected to provide ideas for the design of more effective thrombus treatment agents.
{"title":"Micromotors based on mesoporous silica tubes for thrombus therapy","authors":"Yuning Sun, Junfeng Zhu, Boqian Zhu, Jia Huang","doi":"10.1680/jbibn.23.00005","DOIUrl":"https://doi.org/10.1680/jbibn.23.00005","url":null,"abstract":"To solve the problems of traditional drug carriers such as their single structure and lack of graded release, this work designs and synthesizes a kind of microporous–mesoporous silica tube (MST) with a macroporous and mesoporous structure. Then, manganese dioxide (MnO<sub>2</sub>) nanoparticles prepared using the hydrothermal method are embedded in the macropores to form an MST/Mn micromotor, which is then loaded with heparin and urokinase for thrombolytic therapy. The motion behavior of the micromotor is also investigated. Both static and dynamic thrombolytic therapy are detected, and the results indicate that a better thrombolytic effect can be observed on the MST/manganese micromotor with a motion ability compared with the samples without a motion ability. This research is expected to provide ideas for the design of more effective thrombus treatment agents.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140300472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Malgorzata Pawinska, Elzbieta Paszynska, Hardy Limeback, Bennett T Amaechi, Helge-Otto Fabritius, Bernhard Ganss, Kelsey O’Hagan-Wong, Erik Schulze zur Wiesche, Frederic Meyer, Joachim Enax
Hydroxyapatite, Ca5(PO4)3(OH), is a bio-inspired active ingredient for preventive oral health care. The use of hydroxyapatite in the prevention of oral diseases has gained, especially in recent years. Hydroxyapatite can be used in-office and for daily oral care (e.g., in toothpastes and mouthwashes). The first clinical efficacy studies on caries prevention and reduction of symptoms of dentin hypersensitivity were conducted in the 1980s. This was followed by various in vitro and in situ studies and several more recent clinical trials. A number of systematic reviews and meta-analyses on the use of hydroxyapatite in preventing oral health problems have been published. Summarizing these data, hydroxyapatite is a versatile active ingredient with multiple benefits that include caries prevention, relief from dentin hypersensitivity, and tooth whitening. Since this calcium phosphate mineral has an excellent biocompatibility, it is safe for all patient groups. This interdisciplinary review gives an overview of the developments in hydroxyapatite research, highlights the research progress made regarding hydroxyapatite as a biomimetic active ingredient, and summarizes the state-of-the-art evidence in support of hydroxyapatite efficacy.
{"title":"Hydroxyapatite as an active ingredient in oral care: an international symposium report","authors":"Malgorzata Pawinska, Elzbieta Paszynska, Hardy Limeback, Bennett T Amaechi, Helge-Otto Fabritius, Bernhard Ganss, Kelsey O’Hagan-Wong, Erik Schulze zur Wiesche, Frederic Meyer, Joachim Enax","doi":"10.1680/jbibn.23.00034","DOIUrl":"https://doi.org/10.1680/jbibn.23.00034","url":null,"abstract":"Hydroxyapatite, Ca<sub>5</sub>(PO<sub>4</sub>)<sub>3</sub>(OH), is a bio-inspired active ingredient for preventive oral health care. The use of hydroxyapatite in the prevention of oral diseases has gained, especially in recent years. Hydroxyapatite can be used in-office and for daily oral care (e.g., in toothpastes and mouthwashes). The first clinical efficacy studies on caries prevention and reduction of symptoms of dentin hypersensitivity were conducted in the 1980s. This was followed by various <i>in vitro</i> and <i>in situ</i> studies and several more recent clinical trials. A number of systematic reviews and meta-analyses on the use of hydroxyapatite in preventing oral health problems have been published. Summarizing these data, hydroxyapatite is a versatile active ingredient with multiple benefits that include caries prevention, relief from dentin hypersensitivity, and tooth whitening. Since this calcium phosphate mineral has an excellent biocompatibility, it is safe for all patient groups. This interdisciplinary review gives an overview of the developments in hydroxyapatite research, highlights the research progress made regarding hydroxyapatite as a biomimetic active ingredient, and summarizes the state-of-the-art evidence in support of hydroxyapatite efficacy.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":"62 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138512659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Turkey has the largest colemanite reserves in the world, mainly used in glass and boric acid productions. In order to broaden the current applications of colemanite, it was previously transformed to apatite by a novel method within the same working group of the authors. Natural bone is an organic–inorganic composite where inorganic apatite crystals are accumulated on organic collagen fibers. With inspiration from nature, one further step was taken as an addition to the previous study: apatite, produced from colemanite, and Polyvinyl alcohol (PVA) were mixed with different weight ratios, and, then dried by a spray dryer to investigate the effect of PVA content on the composite structure and to see the effect of using a spray dryer on the morphology of the composites. The weight ratios of Apatite-PVA were maintained as 3:7, 5:5 and 8:2. Samples in each step were analyzed by XRD, FTIR, and SEM. It showed that spray dried Apatite-PVA composites were successfully synthesized and could be potential biomaterials. Using a spray dryer and the manipulation of the weight ratios of the Apatite-PVA were effective ways to tailor the particle size of the powder and the morphology of the particles, which could be beneficial for their biomedical usage.
{"title":"Effect of polyvinyl alcohol (PVA) weight ratio on spray dried apatite-PVA composites","authors":"T Başargan, G Nasün-Saygili","doi":"10.1680/jbibn.23.00013","DOIUrl":"https://doi.org/10.1680/jbibn.23.00013","url":null,"abstract":"Turkey has the largest colemanite reserves in the world, mainly used in glass and boric acid productions. In order to broaden the current applications of colemanite, it was previously transformed to apatite by a novel method within the same working group of the authors. Natural bone is an organic–inorganic composite where inorganic apatite crystals are accumulated on organic collagen fibers. With inspiration from nature, one further step was taken as an addition to the previous study: apatite, produced from colemanite, and Polyvinyl alcohol (PVA) were mixed with different weight ratios, and, then dried by a spray dryer to investigate the effect of PVA content on the composite structure and to see the effect of using a spray dryer on the morphology of the composites. The weight ratios of Apatite-PVA were maintained as 3:7, 5:5 and 8:2. Samples in each step were analyzed by XRD, FTIR, and SEM. It showed that spray dried Apatite-PVA composites were successfully synthesized and could be potential biomaterials. Using a spray dryer and the manipulation of the weight ratios of the Apatite-PVA were effective ways to tailor the particle size of the powder and the morphology of the particles, which could be beneficial for their biomedical usage.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":"74 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138512660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Poly (vinyl alcohol) (PVA) is a synthetic, bioinert, semi-crystalline, biodegradable, non-toxic, and thermoplastic polymer extensively used in the field of biomedical engineering. On the other hand, weak mechanical properties of PVA such as low strength and young’s modulus limit its application as a bone implant. Therefore, PVA can be reinforced with a suitable material to improve its mechanical properties. Carbon fiber-polyetheretherketone (CF-PEEK) is a superior thermoplastic synthetic biomaterial with good tensile strength, stiffness, wear properties and X-ray translucence. In the present study, CF-PEEK reinforced PVA composites were prepared by varying the CF-PEEK (0%, 0.25%, 0.5%, 0.75%, 1%, 2%, 3% w/v) concentration in the PVA matrix (10% w/v) by solvent casting method. The physical, chemical, biological and mechanical properties of the prepared PVA-CF-PEEK composites were studied. The environmental scanning electron microscopy (ESEM) micrographs showed agglomeration of CF-PEEK at higher concentration i.e., 1%, 2%, 3% w/v. With the inclusion of CF-PEEK in PVA, the composites contact angle was found to be increased. The increased hydrophobicity of the samples resulted in reduced swelling and degradation rate. In the hemolysis study, the percentage hemolysis values were found to be <5% revealing the hemocompatible nature of the developed composites. An increase in in vitro protein adsorption was observed and cell viability studies showcased the biocompatible nature of the prepared composite samples. Thus, the developed CF-PEEK-PVA polymer composites present great potential for bone graft applications.
{"title":"Carbon fiber polyether-etherketone reinforced polyvinyl alcohol composites for bone graft applications","authors":"Namasivaya Naveen S.","doi":"10.1680/jbibn.23.00055","DOIUrl":"https://doi.org/10.1680/jbibn.23.00055","url":null,"abstract":"Poly (vinyl alcohol) (PVA) is a synthetic, bioinert, semi-crystalline, biodegradable, non-toxic, and thermoplastic polymer extensively used in the field of biomedical engineering. On the other hand, weak mechanical properties of PVA such as low strength and young’s modulus limit its application as a bone implant. Therefore, PVA can be reinforced with a suitable material to improve its mechanical properties. Carbon fiber-polyetheretherketone (CF-PEEK) is a superior thermoplastic synthetic biomaterial with good tensile strength, stiffness, wear properties and X-ray translucence. In the present study, CF-PEEK reinforced PVA composites were prepared by varying the CF-PEEK (0%, 0.25%, 0.5%, 0.75%, 1%, 2%, 3% w/v) concentration in the PVA matrix (10% w/v) by solvent casting method. The physical, chemical, biological and mechanical properties of the prepared PVA-CF-PEEK composites were studied. The environmental scanning electron microscopy (ESEM) micrographs showed agglomeration of CF-PEEK at higher concentration i.e., 1%, 2%, 3% w/v. With the inclusion of CF-PEEK in PVA, the composites contact angle was found to be increased. The increased hydrophobicity of the samples resulted in reduced swelling and degradation rate. In the hemolysis study, the percentage hemolysis values were found to be <5% revealing the hemocompatible nature of the developed composites. An increase in in vitro protein adsorption was observed and cell viability studies showcased the biocompatible nature of the prepared composite samples. Thus, the developed CF-PEEK-PVA polymer composites present great potential for bone graft applications.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":"67 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138512656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tigabu M Bekele, Getachew A Alamnie, Abayneh Girma, Gedefaw B Mebratie
Emerging diseases due to antibiotic-resistant bacteria cause severe health concerns while increasing their negative effects on human health. The overuse or misuse of antimicrobial agents has contributed to the evolution of bacterial resistance to current medications. Bacteria can develop resistance by altering drugs, changing their target sites, forming biofilms and spending more time in the intracellular environment. Due to this, efforts are being made to create novel, alternative nanoantibiotics as a promising strategy to treat bacteria that cause disease and have developed resistance to a variety of drugs. Utilizing their biocidal properties, nanoparticles can be directed for medication delivery to particular tissues and employed as antibacterial agents against a range of illnesses. Targeted medication delivery-related toxicity problems may be solved with the aid of nanoencapsulation technology. This review paper generally provides a conceptual foundation for understanding the complexity of the problem of the development of antibiotic-resistant bacteria, particularly for brand-new synthetic antibiotics. This information will allow researchers to explore the use of nanoparticles in the treatment of multidrug-resistant bacteria.
{"title":"Nanoparticle therapy for antibiotic-resistant bacteria: current methods and prospects","authors":"Tigabu M Bekele, Getachew A Alamnie, Abayneh Girma, Gedefaw B Mebratie","doi":"10.1680/jbibn.22.00056","DOIUrl":"https://doi.org/10.1680/jbibn.22.00056","url":null,"abstract":"Emerging diseases due to antibiotic-resistant bacteria cause severe health concerns while increasing their negative effects on human health. The overuse or misuse of antimicrobial agents has contributed to the evolution of bacterial resistance to current medications. Bacteria can develop resistance by altering drugs, changing their target sites, forming biofilms and spending more time in the intracellular environment. Due to this, efforts are being made to create novel, alternative nanoantibiotics as a promising strategy to treat bacteria that cause disease and have developed resistance to a variety of drugs. Utilizing their biocidal properties, nanoparticles can be directed for medication delivery to particular tissues and employed as antibacterial agents against a range of illnesses. Targeted medication delivery-related toxicity problems may be solved with the aid of nanoencapsulation technology. This review paper generally provides a conceptual foundation for understanding the complexity of the problem of the development of antibiotic-resistant bacteria, particularly for brand-new synthetic antibiotics. This information will allow researchers to explore the use of nanoparticles in the treatment of multidrug-resistant bacteria.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":"62 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138512657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Assadizadeh, Nima Goodarz, Amir Hossein Mahdavi Pak, Seyyed Mohammad Hasan Haghayeghi, Maryam Azimzadeh Irani
Balanomorpha, commonly known as barnacles, are leading biofouling animals belonging to subclass Cirripedia that adhere durably to different submerged surfaces by utilizing a chiefly-proteinaceous cement. According to prior experiments, adhesion is most likely made possible by the self-assembling aggregates reputed as amyloid-like nanofibers. The secreted cement contains numerous proteins among which CP19k and CP20k are thought to have a substantial influence on the adhesion process. The molecular configuration and atomistic interactions that result in this firm cement are not yet completely understood. Herein, AI-based structure prediction and molecular dockings were used to inspect the potential role of AaCP19k and AaCP20k-1 of Amphibalanus amphitrite in the formation of amyloid-like nanofibers. The anticipated structure of AaCP19k was highly accurate and its β-sandwich folding had a close resemblance to cross-β motifs found in amyloid nanofibers. In the AaCP19k, β1-2 and β7-8 act as oligomerization sites where stable dimers and trimers can be assembled. These modeled oligomerization interfaces point to the self-assembly site through which fibrillization might happen. The structural flexibility of AaCP20k-1 yielded low-accurate models, but a conserved β-hairpin and an α-helix were evident with high confidence. These structural properties can be employed in prospective studies to develop bioadhesives and design anti-fouling substances.
{"title":"Structural investigation of Amphibalanus amphitrite cement proteins: an in-silico study","authors":"Mohammad Assadizadeh, Nima Goodarz, Amir Hossein Mahdavi Pak, Seyyed Mohammad Hasan Haghayeghi, Maryam Azimzadeh Irani","doi":"10.1680/jbibn.23.00008","DOIUrl":"https://doi.org/10.1680/jbibn.23.00008","url":null,"abstract":"Balanomorpha, commonly known as barnacles, are leading biofouling animals belonging to subclass Cirripedia that adhere durably to different submerged surfaces by utilizing a chiefly-proteinaceous cement. According to prior experiments, adhesion is most likely made possible by the self-assembling aggregates reputed as amyloid-like nanofibers. The secreted cement contains numerous proteins among which CP19k and CP20k are thought to have a substantial influence on the adhesion process. The molecular configuration and atomistic interactions that result in this firm cement are not yet completely understood. Herein, AI-based structure prediction and molecular dockings were used to inspect the potential role of AaCP19k and AaCP20k-1 of Amphibalanus amphitrite in the formation of amyloid-like nanofibers. The anticipated structure of AaCP19k was highly accurate and its β-sandwich folding had a close resemblance to cross-β motifs found in amyloid nanofibers. In the AaCP19k, β1-2 and β7-8 act as oligomerization sites where stable dimers and trimers can be assembled. These modeled oligomerization interfaces point to the self-assembly site through which fibrillization might happen. The structural flexibility of AaCP20k-1 yielded low-accurate models, but a conserved β-hairpin and an α-helix were evident with high confidence. These structural properties can be employed in prospective studies to develop bioadhesives and design anti-fouling substances.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":"8 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diana Sofía Nolasquez-Cruz, Héctor Flores, Amaury de Jesús Pozos-Guillen, Marco Antonio Alvarez-Perez
Autologous grafts represent the gold standard for regenerated tissues after diseases, trauma or defects. However, the main problems of this strategy are availability, donor site morbidity and postoperative complications. For this reason, a new approach in tissue engineering looks at scaffolds obtained through the decellularization of native extracellular matrices as an alternative technology to circumvent these limitations. Thus, this review aims to focus on the potential for use of acellular grafts, particularly on the methods of decellularization and recellularization, and continues with their application as part of the formulation of bioinks, which would represent a breakthrough in the field of biofabrication due to their naturally bioactive composition, preserving tissue architecture and structural integrity as a potential alternative for tissue regeneration.
{"title":"Strategies of acellular graft scaffold approaches as alternatives to tissue regeneration","authors":"Diana Sofía Nolasquez-Cruz, Héctor Flores, Amaury de Jesús Pozos-Guillen, Marco Antonio Alvarez-Perez","doi":"10.1680/jbibn.22.00072","DOIUrl":"https://doi.org/10.1680/jbibn.22.00072","url":null,"abstract":"Autologous grafts represent the gold standard for regenerated tissues after diseases, trauma or defects. However, the main problems of this strategy are availability, donor site morbidity and postoperative complications. For this reason, a new approach in tissue engineering looks at scaffolds obtained through the decellularization of native extracellular matrices as an alternative technology to circumvent these limitations. Thus, this review aims to focus on the potential for use of acellular grafts, particularly on the methods of decellularization and recellularization, and continues with their application as part of the formulation of bioinks, which would represent a breakthrough in the field of biofabrication due to their naturally bioactive composition, preserving tissue architecture and structural integrity as a potential alternative for tissue regeneration.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":"582 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136254311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pemula Gowtham, V. Arumugam, Karthick Harini, P. Pallavi, Anbazhagan Thirumalai, K. Girigoswami, A. Girigoswami
During the last few years, nanostructures based on proteins have been playing a vital role in revolutionizing the nanomedicine era. Since protein nanoparticles are smaller and have a greater surface area, they retain a better capacity to interact with other molecules, resulting in carrying payloads efficiently to the diseased tissues. Besides having attractive biocompatibility and biodegradability, protein nanoparticles can also be modified on their surfaces. For the fabrication of these nanostructures, there are several processes involved, including emulsification, desolvation, a combination of complex coacervation, and electrospray. This can be achieved by using different proteins such as albumin, gelatin, elastin, gliadin, collagen, legumin, and zein, as well as a combination of these proteins. It is possible to functionalize protein nanoparticles by altering their internal and external interfaces so that they can encapsulate drugs, release them in a controlled manner, disassemble them systematically, and target tumors. This review highlights the physicochemical properties and engineering of several proteins to nano-dimensions used to deliver drugs to diseased tissues.
{"title":"Nanostructured proteins for delivering drugs to diseased tissues","authors":"Pemula Gowtham, V. Arumugam, Karthick Harini, P. Pallavi, Anbazhagan Thirumalai, K. Girigoswami, A. Girigoswami","doi":"10.1680/jbibn.23.00004","DOIUrl":"https://doi.org/10.1680/jbibn.23.00004","url":null,"abstract":"During the last few years, nanostructures based on proteins have been playing a vital role in revolutionizing the nanomedicine era. Since protein nanoparticles are smaller and have a greater surface area, they retain a better capacity to interact with other molecules, resulting in carrying payloads efficiently to the diseased tissues. Besides having attractive biocompatibility and biodegradability, protein nanoparticles can also be modified on their surfaces. For the fabrication of these nanostructures, there are several processes involved, including emulsification, desolvation, a combination of complex coacervation, and electrospray. This can be achieved by using different proteins such as albumin, gelatin, elastin, gliadin, collagen, legumin, and zein, as well as a combination of these proteins. It is possible to functionalize protein nanoparticles by altering their internal and external interfaces so that they can encapsulate drugs, release them in a controlled manner, disassemble them systematically, and target tumors. This review highlights the physicochemical properties and engineering of several proteins to nano-dimensions used to deliver drugs to diseased tissues.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46652143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Kribaa, Chams Edoha Labidi, H. Djouama, Lamia Laacher
Hydroxyapatite is a biomaterial that has a great importance in medical field, commonly used as implants to replace amputated bone, tissues, organ transplants and drug delivery systems. Quantum chemistry is based on functional theory (DFT), which is an important tool for understanding structural arrangements and explaining the Physico-chemical properties of complexes. This work is mainly based on synthesis of hydroxyapatite by double decomposition method, The fine powder has been characterized by different techniques such as infrared spectroscopy, X-ray diffraction method, scanning electron microscopy, and density measurement .The crystalline microstructure of hydroxyapatite is hexagonal with the following lattice parameters (a=b=9.4260 Å, c=6.8850 Å) and space group P63/m. A porous surface particle morphology with a regular spherical shape. An agreement of the energies of the vibrational frequency of bond that are characteristic of the IR spectrum. The geometry of complex isolated by the DFT method is optimized in open air and in various solvents; different functions are chosen in order to determine the energies of excitation and the forces of associated oscillator of studied complex. Theoretical absorption spectra were obtained using Gauss View software and the origin.
{"title":"Coupled experimental and theoretical study of hydroxyapatite ceramic","authors":"O. Kribaa, Chams Edoha Labidi, H. Djouama, Lamia Laacher","doi":"10.1680/jbibn.23.00007","DOIUrl":"https://doi.org/10.1680/jbibn.23.00007","url":null,"abstract":"Hydroxyapatite is a biomaterial that has a great importance in medical field, commonly used as implants to replace amputated bone, tissues, organ transplants and drug delivery systems. Quantum chemistry is based on functional theory (DFT), which is an important tool for understanding structural arrangements and explaining the Physico-chemical properties of complexes. This work is mainly based on synthesis of hydroxyapatite by double decomposition method, The fine powder has been characterized by different techniques such as infrared spectroscopy, X-ray diffraction method, scanning electron microscopy, and density measurement .The crystalline microstructure of hydroxyapatite is hexagonal with the following lattice parameters (a=b=9.4260 Å, c=6.8850 Å) and space group P63/m. A porous surface particle morphology with a regular spherical shape. An agreement of the energies of the vibrational frequency of bond that are characteristic of the IR spectrum. The geometry of complex isolated by the DFT method is optimized in open air and in various solvents; different functions are chosen in order to determine the energies of excitation and the forces of associated oscillator of studied complex. Theoretical absorption spectra were obtained using Gauss View software and the origin.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47757212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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