Histopathological evaluation of amino acid capped silver nanoconjugates in albino mice

IF 1.3 4区 工程技术 Q4 ENGINEERING, BIOMEDICAL Bioinspired Biomimetic and Nanobiomaterials Pub Date : 2021-12-22 DOI:21.00033
Sarwar Allah Ditta, Atif Yaqub, Fouzia Tanvir, Rehan Ullah, Muhammad Rashid, Muhammad Bilal
{"title":"Histopathological evaluation of amino acid capped silver nanoconjugates in albino mice","authors":"Sarwar Allah Ditta, Atif Yaqub, Fouzia Tanvir, Rehan Ullah, Muhammad Rashid, Muhammad Bilal","doi":"21.00033","DOIUrl":null,"url":null,"abstract":"Various molecules may modify the surface chemistry of commonly used nanomaterials (NMs), resulting in the synthesis of novel and safer NMs. The current study was delineated to evaluate the in vivo toxicity profiling of the silver nanoconjugates (AgNCs) conjugated with different amino acids. The L-glycine capped-AgNCs exhibited toxicity and caused tissue damage, while L-cystine- and L-tyrosine-capped AgNCs showed protective effects against cadmium-induced toxicity. L-cystine-capped AgNCs performed well as compared to other amino-acid AgNCs. The level of serum creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and blood urea increased (<i>p</i> &lt; 0.05) in G2, G3 and G5 in comparison to G1 (control group), while an increase in bilirubin for G2 was statistically non-significant (<i>p</i> &gt; 0.05). The ALT and AST elevated (<i>p</i> &lt; 0.05) in G4; however, other serological parameters in G4 and G6 did not show any noticeable change in their values. Histological analysis showed disturbed and deformed cellular structures in liver and kidney tissues of G2, G3 and G5. However, G4 and G6 samples demonstrated minute changes in comparison to G1. It is concluded that L-cystine- and L-tyrosine-capped AgNCs exhibited protective effects and should be tested further for developing safer nanoconjugates for biomedical uses.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":"73 1","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinspired Biomimetic and Nanobiomaterials","FirstCategoryId":"5","ListUrlMain":"https://doi.org/21.00033","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0

Abstract

Various molecules may modify the surface chemistry of commonly used nanomaterials (NMs), resulting in the synthesis of novel and safer NMs. The current study was delineated to evaluate the in vivo toxicity profiling of the silver nanoconjugates (AgNCs) conjugated with different amino acids. The L-glycine capped-AgNCs exhibited toxicity and caused tissue damage, while L-cystine- and L-tyrosine-capped AgNCs showed protective effects against cadmium-induced toxicity. L-cystine-capped AgNCs performed well as compared to other amino-acid AgNCs. The level of serum creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and blood urea increased (p < 0.05) in G2, G3 and G5 in comparison to G1 (control group), while an increase in bilirubin for G2 was statistically non-significant (p > 0.05). The ALT and AST elevated (p < 0.05) in G4; however, other serological parameters in G4 and G6 did not show any noticeable change in their values. Histological analysis showed disturbed and deformed cellular structures in liver and kidney tissues of G2, G3 and G5. However, G4 and G6 samples demonstrated minute changes in comparison to G1. It is concluded that L-cystine- and L-tyrosine-capped AgNCs exhibited protective effects and should be tested further for developing safer nanoconjugates for biomedical uses.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
氨基酸覆盖银纳米偶联物在白化病小鼠中的组织病理学评价
各种分子可以修饰常用纳米材料的表面化学性质,从而合成新的、更安全的纳米材料。本研究旨在评价不同氨基酸偶联银纳米偶联物(agnc)的体内毒性。l -甘氨酸包盖的AgNCs表现出毒性并引起组织损伤,而l -胱氨酸和l -酪氨酸包盖的AgNCs对镉诱导的毒性表现出保护作用。与其他氨基酸agnc相比,l -胱氨酸封顶agnc表现良好。血清肌酐、谷丙转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶和血尿素水平升高(p <与G1(对照组)相比,G2、G3和G5的胆红素升高无统计学意义(p >0.05)。ALT和AST升高(p <0.05);而G4、G6的其他血清学参数无明显变化。组织学分析显示G2、G3和G5的肝、肾组织细胞结构紊乱和变形。然而,与G1相比,G4和G6样品表现出微小的变化。综上所述,l -胱氨酸和l -酪氨酸覆盖的agnc具有保护作用,应该进一步测试以开发用于生物医学用途的更安全的纳米偶联物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Bioinspired Biomimetic and Nanobiomaterials
Bioinspired Biomimetic and Nanobiomaterials ENGINEERING, BIOMEDICAL-MATERIALS SCIENCE, BIOMATERIALS
CiteScore
2.20
自引率
0.00%
发文量
12
期刊介绍: Bioinspired, biomimetic and nanobiomaterials are emerging as the most promising area of research within the area of biological materials science and engineering. The technological significance of this area is immense for applications as diverse as tissue engineering and drug delivery biosystems to biomimicked sensors and optical devices. Bioinspired, Biomimetic and Nanobiomaterials provides a unique scholarly forum for discussion and reporting of structure sensitive functional properties of nature inspired materials.
期刊最新文献
Micromotors based on mesoporous silica tubes for thrombus therapy Hydroxyapatite as an active ingredient in oral care: an international symposium report Effect of polyvinyl alcohol (PVA) weight ratio on spray dried apatite-PVA composites Carbon fiber polyether-etherketone reinforced polyvinyl alcohol composites for bone graft applications Nanoparticle therapy for antibiotic-resistant bacteria: current methods and prospects
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1