ANTIMICROBIAL ACTIVITY OF THREE ITALIAN STRAINS OF MORCHELLA ESCULENTA (ASCOMYCOTA, PEZIZALES)

IF 1.4 4区 生物学 Q4 MYCOLOGY International journal of medicinal mushrooms Pub Date : 2023-12-01 DOI:10.1615/intjmedmushrooms.2023051956
Susanna Badalyan, Susanna Badalyan, Narine Gharibyan, Alessandra Zambonelli
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Abstract

Three genetically identified and morphologically characterized strains (MesAQ2-C, MesAQ6–2 and MesFI2-3) of the culinary-medicinal ascomycete mushroom Morchella esculenta (L.) Pers. collected in central-north Italy have been studied for their antifungal and antibacterial activities. The obtained data showed that mycelium of M. esculenta possess variable antimicrobial activity against four test fungi (Chrysosporium keratinophilum, Microsporum gypseum, Trichophyton terrestre, Penicillium griseofulvum), as well as one Gram positive (Staphylococcus aureus) and three Gram negative (Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa) test bacteria potentially pathogenic for humans and animals. Up to 20.4% of inhibition of the average mycelial growth rate (GRavr) of test fungi in dual culture experiment was detected. The samples of cultural liquid (CL) and mycelial extract (ME) obtained by static cultivation of M. esculenta strains showed up to 13.9 and 23.0% of GRavr inhibition of test fungi, respectively. Similarly, the inhibition of the bacterial colonies by CL and ME samples was 34.1 and 32.3%, respectively in comparison with the control with streptomycin indicating almost equal secretion of both intra- and extracellular antimicrobial compounds by M. esculenta mycelium. As a producer of antimicrobial compounds among tested M. esculenta strains, MesAQ2-C was the most effective. It may be considered for further myco-pharmacological research to develop mushroom-based antimicrobial biotech products with biomedical significance.
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意大利三株莫切莱氏菌(子囊菌目,pezizales)的抗菌活性
研究人员对在意大利中北部采集的三种经基因鉴定和形态特征描述的烹饪-药用子实体蘑菇 Morchella esculenta (L.) Pers.菌株(MesAQ2-C、MesAQ6-2 和 MesFI2-3)进行了抗真菌和抗菌活性研究。获得的数据表明,莫希拉菌丝体对四种测试真菌(角质嗜酸性真菌、小孢子菌、毛霉菌、灰青霉)以及一种革兰氏阳性菌(金黄色葡萄球菌)和三种革兰氏阴性菌(大肠杆菌、伤寒沙门氏菌、绿脓杆菌)具有不同的抗菌活性。在双重培养实验中,对测试真菌菌丝平均生长率(GRavr)的抑制率高达 20.4%。通过静态培养 M. esculenta 菌株获得的培养液(CL)和菌丝体提取物(ME)样品对试验真菌的平均菌丝生长率抑制率分别高达 13.9% 和 23.0%。同样,与链霉素对照组相比,CL 和 ME 样品对细菌菌落的抑制率分别为 34.1% 和 32.3%,这表明菌丝体在细胞内和细胞外分泌的抗菌化合物几乎相同。在测试的 M. esculenta 菌株中,MesAQ2-C 是最有效的抗菌化合物生产者。可考虑对其进行进一步的菌药学研究,以开发具有生物医学意义的蘑菇基抗菌生物技术产品。
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来源期刊
CiteScore
2.60
自引率
16.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.
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