Enhancement of Cordycepin Production Through Liquid Static Fermentation of Caterpillar Medicinal Mushroom Cordycep militaris (Ascomycetes)

IF 1.4 4区 生物学 Q4 MYCOLOGY International journal of medicinal mushrooms Pub Date : 2024-08-01 DOI:10.1615/intjmedmushrooms.2024055323
Mahesh Borde, Shweta Kumawat, Sanjay K. Singh
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Abstract

Cordycepin (3′-deoxyadenosine) is a bioactive nucleoside analogue synthesise by Cordyceps militaris. Liquid fermentation of C. militaris by addition in different concentrations of five additives singly was evaluated. glycine at 15.00 g/L after 20 days enhanced the cordycepin of 1773.33 mg/L (15-fold increment over control). adenine at 4.00 g/L and 6.00 g/L in the liquid media showed significantly higher cordycepin i.e.1596.66 mg/L and 1550.00 mg/L (3-fold increment over control) after 40 days. Tryptone supplementation 14.00 g/L significantly higher cordycepin 784.33 mg/L (6.70-fold increment over control) and 912.66 mg/L production after 20 and 40 days of inoculation. Peanut oil at 10.00 g/L produced 585.66 mg/L (5-fold increment over control) cordycepin after 20 days and after 40 days, also addition of Peanut oil at 20.00 g/L and 30.00 g/L in the media showed 631.66 and 624.31 mg/L cordycepin content. Supplementation of monosodium glutamate at 0.30 g/L produced significantly highest cordycepin i.e. 614 mg/L and 635.00 mg/L cordycepin after 20 and 40 days respectively.
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通过液体静态发酵提高毛虫药用蘑菇虫草菌(子囊菌)的虫草素产量
虫草素(3′-脱氧腺苷)是冬虫夏草合成的一种生物活性核苷类似物。在液体培养基中添加 4.00 克/升和 6.00 克/升的腺嘌呤,40 天后,虫草素的含量明显增加,分别为 1596.66 毫克/升和 1550.00 毫克/升(比对照组增加 3 倍)。胰蛋白胨添加量为 14.00 克/升,接种 20 天和 40 天后,虫草素产量分别为 784.33 毫克/升(比对照高出 6.70 倍)和 912.66 毫克/升(比对照高出 3 倍)。在培养基中添加 10.00 克/升的花生油,20 天和 40 天后虫草素产量分别为 585.66 毫克/升(比对照高 5 倍),添加 20.00 克/升和 30.00 克/升的花生油,虫草素含量分别为 631.66 毫克/升和 624.31 毫克/升。添加 0.30 克/升的谷氨酸钠在 20 天和 40 天后产生的虫草素明显最高,分别为 614 毫克/升和 635.00 毫克/升。
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来源期刊
CiteScore
2.60
自引率
16.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.
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