Neuroprotective Effects of Rosa damascena Extract against Aluminum Chloride-Induced Brain Damage in Rat Offspring

IF 1.7 Q4 NEUROSCIENCES Neurology Research International Pub Date : 2023-12-04 DOI:10.1155/2023/5342849
Leila Beigom Hejazian, S. M. Hosseini, Alireza Salehi
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Abstract

Aluminum (Al) is a popular metal in the industry, and its usage has greatly increased recently. The dose of this metal has been proven to be toxic to rats, but its effects on the offspring of the original receivers and prevention methods to reduce this damage are unknown. Rosa damascena is a well-known plant for its high antioxidant capabilities. In this study, the protective effect of Rosa damascena extract (RDA) on aluminum-induced lesions in the brain tissue of a rat offspring was investigated. In this regard, female rats were divided into seven groups, including the control group, the sham group, the aluminum group at the dose of 100 mg/kg, the extract groups at the doses of 500 and 1000 mg/kg, and the treatment groups that received the extract and Al at the same doses. After the treatment ended, the offsprings were subjected to exploratory behavioral tests, and finally, the tissues of the brain including the cerebral cortex, hippocampus, and hypothalamus were pathologically examined. It was observed that RDA at the dose of 1000 mg/kg reduced the malondialdehyde (MDA) and acetylcholinesterase (AChE) levels significantly (P < 0.0001), while raising the catalase and FRAP indices in Al-treated rats. Moreover, it increased neuronal counts significantly and reduced necrosis and vacuolar degeneration in both the cortex and hippocampus compared to the Al-receiving group. In addition, the administration of RDA 1000 improved the behavioral test scores of the offspring. In conclusion, RDA can effectively reduce Al-induced damage in the brain tissue of the offspring.
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大马士革蔷薇提取物对氯化铝诱导的大鼠后代脑损伤的神经保护作用
铝(Al)是一种在工业上很受欢迎的金属,近年来其使用量大大增加。这种金属的剂量已被证明对大鼠有毒,但它对原始受体后代的影响以及减少这种损害的预防方法尚不清楚。大马士革玫瑰是一种众所周知的抗氧化能力强的植物。本研究探讨了大马士革玫瑰提取物(RDA)对铝致大鼠后代脑组织损伤的保护作用。为此,将雌性大鼠分为7组,分别为对照组、假手术组、100 mg/kg剂量的铝组、500、1000 mg/kg剂量的提取物组和相同剂量的铝提取物治疗组。治疗结束后,对后代进行探索性行为测试,最后对大脑皮层、海马、下丘脑等组织进行病理检查。1000mg /kg剂量RDA显著降低了al处理大鼠丙二醛(MDA)和乙酰胆碱酯酶(AChE)水平(P < 0.0001),提高了过氧化氢酶和FRAP指数。此外,与al受体组相比,它显著增加了神经元计数,减少了皮层和海马的坏死和空泡变性。此外,RDA 1000的施用提高了后代的行为测试成绩。综上所述,RDA能有效减轻al对子代脑组织的损伤。
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来源期刊
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
17 weeks
期刊介绍: Neurology Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focusing on diseases of the nervous system, as well as normal neurological functioning. The journal will consider basic, translational, and clinical research, including animal models and clinical trials.
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