{"title":"Block Copolymer-Stabilized Metal–Organic Framework Hybrids Loading Pd Nanoparticles Enable Tumor Remission Through Near-Infrared Photothermal Therapy","authors":"Shang-Wei Li, Ming-Feng Hsieh, Taehun Hong, Pengwen Chen, Kensuke Osada, Xueying Liu, Ichio Aoki, Jiashing Yu, Kevin C.-W. Wu, Horacio Cabral","doi":"10.1002/anbr.202300107","DOIUrl":null,"url":null,"abstract":"<p>Metal–organic frameworks (MOFs), such as the magnetic resonance imaging-fit MIL-100 based on Fe, are gaining significant attention as versatile theranostics with high-loading capability. Moreover, as MOFs can be engineered to target tumors, there is much interest in applying them for precise pin-point treatment of cancer. Herein, Pd nanoparticles within MIL-100(Fe) are generated to create MOFs with remarkable photothermal conversion properties for cancer therapy. The Pd-loaded MIL-100(Fe) (Pd@MIL-100(Fe)) are stabilized with biocompatible block copolymers to generate MOFs with PEGylated surfaces. This is achieved by directly mixing poly(ethylene glycol)-poly(L-aspartic acid) (PEG-p(Asp)) or dopamine-modified PEG-p(Asp) (PEG-p(Asp-Dopa)) block copolymers with the MOFs in aqueous conditions. The resulting block copolymer-stabilized MOF hybrids are stable in physiological conditions. Particularly, the Pd@MIL-100(Fe)/PEG-p(Asp-Dopa) hybrids show enhanced blood circulation and increased accumulation in B16F10 melanoma. Furthermore, when irradiated with 808 nm light, the Pd@MIL-100(Fe)/PEG-p(Asp-Dopa) hybrids rapidly increase the temperature to 50 °C, enabling tumor remission. The surface-stabilized Pd@MIL-100(Fe)/polymer hybrids open viable opportunities for innovating MOF/polymer hybrid-based approaches for drug delivery.</p>","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 1","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300107","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Nanobiomed Research","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/anbr.202300107","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Metal–organic frameworks (MOFs), such as the magnetic resonance imaging-fit MIL-100 based on Fe, are gaining significant attention as versatile theranostics with high-loading capability. Moreover, as MOFs can be engineered to target tumors, there is much interest in applying them for precise pin-point treatment of cancer. Herein, Pd nanoparticles within MIL-100(Fe) are generated to create MOFs with remarkable photothermal conversion properties for cancer therapy. The Pd-loaded MIL-100(Fe) (Pd@MIL-100(Fe)) are stabilized with biocompatible block copolymers to generate MOFs with PEGylated surfaces. This is achieved by directly mixing poly(ethylene glycol)-poly(L-aspartic acid) (PEG-p(Asp)) or dopamine-modified PEG-p(Asp) (PEG-p(Asp-Dopa)) block copolymers with the MOFs in aqueous conditions. The resulting block copolymer-stabilized MOF hybrids are stable in physiological conditions. Particularly, the Pd@MIL-100(Fe)/PEG-p(Asp-Dopa) hybrids show enhanced blood circulation and increased accumulation in B16F10 melanoma. Furthermore, when irradiated with 808 nm light, the Pd@MIL-100(Fe)/PEG-p(Asp-Dopa) hybrids rapidly increase the temperature to 50 °C, enabling tumor remission. The surface-stabilized Pd@MIL-100(Fe)/polymer hybrids open viable opportunities for innovating MOF/polymer hybrid-based approaches for drug delivery.
期刊介绍：
Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science.
The scope of Advanced NanoBiomed Research will cover the following key subject areas:
▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging.
▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications.
▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture.
▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs.
▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization.
▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems.
with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
